Results 111 to 120 of about 24,916 (232)

Biology of the Adenomatous Polyposis Coli Tumor Suppressor

, 2000
: The adenomatous polyposis coli (APC) gene was first identified as the gene mutated in an inherited syndrome of colon cancer predisposition known as familial adenomatous polyposis coli (FAP).
Joanna Groden, Kathleen Heppner Goss
core   +1 more source

Reduced Oligodendrocyte Density and Axonal Caliber Associated With Mitochondrial Alterations in the White Matter of Chronically‐Starved Mice

International Journal of Eating Disorders, Volume 59, Issue 5, Page 869-884, May 2026.
ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with extreme weight loss, hyperactivity, and amenorrhea. Neuroimaging studies revealed brain atrophy and disruption of white matter integrity in the corpus callosum (CC) of patients with AN. However, the underlying pathophysiological mechanisms remain unclear.
Stephan Lang, Annelie Zimmermann, Kaja Dickert, Hanna Rupprecht, Julia Priebe, Fabienne Haberland, Hanna‐Sophia Henschke, Katharina Schuster, Marcus Frank, Linda Frintrop   +9 more
wiley   +1 more source

Habitual consumption of fruits and vegetables: associations with human rectal glutathione S-transferase.

, 2004
The glutathione (GSH)/glutathione S-transferase (GST) system is an important detoxification system in the gastrointestinal tract. A high activity of this system may benefit cancer prevention.
Peters, Wilbert HM, Nagengast, Fokko M, Wark, P.A., Kok, F.J., Veer, P., van 't, Peters, Wilbert H M, Kampman, Ellen, Nagengast, Fokko M., Kok, Frans J., Grubben, Marina JAL, Grubben, M.J.A.L., van 't Veer, P., van't Veer, Pieter, Wark, Petra A, Kampman, E., Nagengast, F.M., Wark, Petra A.; id_orcid, Veer, P. van 't, Grubben, Marina J A L, van 't Veer, Pieter, Kok, Frans J, Peters, W.H.M.   +21 more
core   +1 more source

Agrin promotes acetylcholine receptor clustering at the mammalian neuro-muscular junction by PI3K/GSK3ß²-mediated regulation of +TIPs and microtubule capture [PDF]

, 2013
Neurotransmission an der neuromuskulären Endplatte von Säugetieren erfolgt durch Ausschüttung von Acetylcholin (ACh) aus motorischen Nerven in den synaptischen Spalt und verursacht letztendlich Muskelkontraktion im angesteuerten Muskel.
Sladecek, Stefan
core   +1 more source

Circular RNA hsa_circ_0005114-miR-142-3p/miR-590-5p-adenomatous polyposis coli protein axis as a potential target for treatment of glioma. [PDF]

Oncol Lett, 2021
Wei B, Wang L, Zhao J.
europepmc   +1 more source

The Initiation and Progression of Neoplasia in Inherited and Sporadic Colorectal Cancer.

, 2009
PhDThis dissertation describes investigations into aspects of neoplastic initiation and progression in the gut, in the context of inherited and sporadic gastrointestinal cancer. In familial adenomatous polyposis, there is marked locoregional variation
Will, Olivia Constance Claire
core  

Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands). [PDF]

, 2005
OBJECTIVE: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer.
Roemen, Guido M J M, Brandt, P.A. van den, Goldbohm, R.A., Goldbohm, R Alexandra, Lentjes, Marjolein H F M, Lentjes, Marjolein HFM, van den Brandt, Piet A, Wark, Petra A.; id_orcid, Goldbohm, R. Alexandra, Van Den Brandt, Piet A., Veer, P. van 't, van 't Veer, Pieter, Bruine, A.P., de, Weijenberg, Matty P., Weijenberg, Matty P, Roemen, G.M.J.M., de Bruïne, Adriaan P, de Goeij, Anton FPM, Wark, P.A., De Goeij, Anton F P M, Veer, P., van 't, Bruïne, A.P. de, Brink, M., van 't Veer, P., van den Brandt, P.A., Luchtenborg, M., Goeij, A.F.P.M. de, De Bruïne, Adriaan P., de Bruine, A.P., Weijenberg, M.P., Wark, Petra A, Lüchtenborg, Margreet, Roemen, Guido MJM, Brink, Mirian, de Goeij, A.F., Goeij, A.F.P.M., de, Lentjes, M.H.F.M., de Goeij, A.F.P.M., Van't Veer, Pieter, Brandt, P.A., van den   +39 more
core   +1 more source

m6A RNA methylation-mediated control of global APC expression is required for local translation of β-actin and axon development

Cell Reports
Summary: The spatial regulation of mRNAs in neurons, including their localization and translation, is controlled by RNA-binding proteins and is critical for neuronal development.
Loic Broix, Rohini Roy, Belal Shohayeb, Ikumi Oomoto, Hiroki Umeshima, Dan Ohtan Wang   +5 more
doaj   +1 more source

Activated Akt antagonizes adenomatous polyposis coli protein.

, 2006
Activated Akt antagonizes adenomatous polyposis coli ...
Joel. Jacobs (7977965)
core  

Rho GTPase Cdc42 Is a Direct Interacting Partner of Adenomatous Polyposis Coli Protein and Can Alter Its Cellular Localization

PLoS ONE, 2011
Adenomatous Polyposis Coli (APC) is a tumor suppressor gene product involved in colon cancer. APC is a large multidomain molecule of 2843 amino acid residues and connects cell-cell adhesion, the F-actin/microtubule cytoskeleton and the nucleus.
T. Sudhaharan, Wah Ing Goh, K. Sem, K. B. Lim, Wenyu Bu, Sohail Ahmed   +5 more
semanticscholar   +1 more source