Results 111 to 120 of about 30,293 (217)
APMIS, Volume 134, Issue 5, May 2026.ABSTRACT Familial adenomatous polyposis (FAP) is a hereditary condition marked by the growth of hundreds to thousands of adenomatous polyps in the colon and rectum, significantly elevating the risk of colorectal cancer (CRC) if left untreated. Caused by pathogenic variants in the APC gene, FAP is typically identified in adolescence, often leading to ...
John Gásdal Karstensen
wiley +1 more source
The APC Network Regulates the Removal of Mutated Cells from Colonic Crypts
Cell Reports, 2014 Self-renewal is essential for multicellular organisms but carries the risk of somatic mutations that can lead to cancer, which is particularly critical for rapidly renewing tissues in a highly mutagenic environment such as the intestinal epithelium ...
Je-Hoon Song +6 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
Functional definition of the mutation cluster region of adenomatous polyposis coli in colorectal tumours [PDF]
, 2017 The mutation cluster region (MCR) of adenomatous polyposis coli (APC) is located within the central part of the open reading frame, overlapping with the region encoding the 20 amino acid repeats (20R) that are β-catenin-binding sites.
Behrens, Jürgen +4 more
core
Familial Adenomatous Polyposis: Experience from a Study of 1164 Unrelated German Polyposis Patients [PDF]
, 2005 The autosomal-dominant precancerous condition familial adenomatous polyposis (FAP) is caused by germline mutations in the tumour suppressor gene APC.
Waltraut Friedl, Stefan Aretz
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska +2 more
wiley +1 more source
Microtubules and actin filaments "cross-talk" in cell migration : role of the formin mDia and the tumor suppressor APC [PDF]
, 2007 Cell migration is a fundamental process throughout the lives of multicellular organisms as well as in the onset of several diseases including cancer formation and metastasis.
Bartolini, Francesca
core +2 more sources
Glucose Metabolism Regulating Colorectal Cancer Initiation and Progression
Cancer Science, Volume 117, Issue 5, Page 1199-1208, May 2026.Drugs and compounds targeting glycolysis in CRC and the mechanisms by which these drugs inhibit their respective targets. ABSTRACT Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake
Meiyi Lin, Junpeng Cui
wiley +1 more source
Targeting Inflammation and Immune Regulation in Chronic Inflammation Associated Cancers
Cancer Science, Volume 117, Issue 5, Page 1209-1222, May 2026.Chronic inflammation sustains activation of key inflammatory pathways, including Nuclear factor kappa B (NF‐κB), Interleukin‐6‐signal transducer and activator of transcription 3 (IL6‐STAT3), Phosphoinositide 3‐kinase/Akt (PI3K/Akt), and Wingless/β‐catenin (Wnt/β‐catenin) signaling. This promotes immune dysregulation through the expansion and functional
Lawan Rabiu +5 more
wiley +1 more source
Circular RNA hsa_circ_0005114-miR-142-3p/miR-590-5p-adenomatous polyposis coli protein axis as a potential target for treatment of glioma. [PDF]
Oncol Lett, 2021 Wei B, Wang L, Zhao J.
europepmc +1 more source