Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comparison: a pilot study [PDF]
BMC Cancer, 2010 Background We are developing a cross-species comparison strategy to distinguish between cancer driver- and passenger gene alteration candidates, by utilizing the difference in genomic location of orthologous genes between the human and other mammals.
Ji Xinglai +8 more
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Frontiers in Cell and Developmental Biology, 2022 The adenomatous polyposis coli (APC) gene is the chromatin-remodeling-related gene and a typical tumor suppressor. Patients with a high expression of programmed death-ligand 1 (PD-L1) or a high level of tumor mutational burden (TMB) may benefit from ...
Yunfeng Song +4 more
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Prediction and testing of biological networks underlying intestinal cancer. [PDF]
PLoS ONE, 2010 Colorectal cancer progresses through an accumulation of somatic mutations, some of which reside in so-called "driver" genes that provide a growth advantage to the tumor.
Vishal N Patel +5 more
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Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium. [PDF]
PLoS Genetics, 2015 Adenomatous polyposis coli (APC) inactivating mutations are present in most human colorectal cancers and some other cancers. The APC protein regulates the β-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated ...
Ying Feng +11 more
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PLoS ONE, 2021 Adenomatous Polyposis Coli (APC) is lost in approximately 70% of sporadic breast cancers, with an inclination towards triple negative breast cancer (TNBC).
Emily M Astarita +6 more
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Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer. [PDF]
PLoS ONE, 2011 Aberrant activation of the Wnt/β-catenin pathway is critical for the initiation and progression of most colon cancers. This activation provokes the accumulation of nuclear β-catenin and the induction of its target genes.
María Jesús Larriba +6 more
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APC Gene Mutations in Human Prostate Cancer [PDF]
Japanese Journal of Clinical Oncology, 1996 Prostate cancer is the most common cancer in aged men. Although ras and p53 gene mutations have been detected in some prostate cancers, the major genetic alterations involved in its carcinogenesis are not well understood. Mutation of the APC gene is responsible for colorectal tumors in which ras and p53 mutations are also often involved. Using PCR-SSCP
M, Watanabe +6 more
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APC Gene Testing for Familial Adenomatosis Polyposis [PDF]
JAMA, 2012 While genomics is destined to revolutionize clinical medicine, to date its beneficial effects have been somewhat muted. The promise and perils of genomics are emblemized by one of its flagship applications, namely the diagnosis of familial adenomatosis polyposis (FAP).
Hemant K, Roy, Janardan D, Khandekar
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Molecular Genetics of Intracranial Meningiomas with Emphasis on Canonical Wnt Signalling. [PDF]
, 2016 Research over the last decade recognized the importance of novel molecular pathways in pathogenesis of intracranial meningiomas. In this review, we focus on human brain tumours meningiomas and the involvement of Wnt signalling pathway genes and proteins ...
Kafka, Anja +2 more
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Genomic alterations in the WNT/β-catenin pathway and resistance of colorectal cancer cells to pathway-targeting therapies [PDF]
Exploration of Targeted Anti-tumor TherapyAim: Colorectal cancer is the most prevalent gastrointestinal malignancy with limited therapeutic options in the metastatic setting. The WNT/β-catenin/adenomatous polyposis coli (APC) pathway is commonly deregulated in the disease and presents a rational
Ioannis A. Voutsadakis
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