Results 1 to 10 of about 155,361 (266)

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

Genomics Data, 2016
The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in about 80% of colorectal cancers (CRC) Brannon et al. (2014) [1]. APC is a large multifunctional protein that regulates many biological functions including Wnt signalling (through ...
Lauren E. King, Christopher G. Love, Oliver M. Sieber, Maree C. Faux, Antony W. Burgess   +4 more
doaj   +1 more source

Genetic mapping of novel modifiers for Apc Min induced intestinal polyps’ development using the genetic architecture power of the collaborative cross mice

BMC Genomics, 2021
Background Familial adenomatous polyposis is an inherited genetic disease, characterized by colorectal polyps. It is caused by inactivating mutations in the Adenomatous polyposis coli (Apc) gene. Mice carrying a nonsense mutation in the Apc gene at R850,
Alexandra Dorman, Ilona Binenbaum, Hanifa J. Abu-Toamih Atamni, Aristotelis Chatziioannou, Ian Tomlinson, Richard Mott, Fuad A. Iraqi   +6 more
doaj   +1 more source

Case Report: Coinheritance of Germline Mutations in APC and BRCA1 in Colorectal Cancer

Frontiers in Oncology, 2021
Deleterious mutations in APC gene cause the autosomal dominant familial adenomatous polyposis (FAP) which is typically characterized by the occurrence of hundreds to thousands of colorectal adenomas that eventually lead to colorectal cancers (CRCs ...
Wei Huang, Jin Bian, Xiaoping Qian, Lin Shao, Haiyan Li, Lu Zhang, Lin Wang   +6 more
doaj   +1 more source

Analysis of hypermethylation and expression profiles of APC and ATM genes in patients with oral squamous cell carcinoma

Clinical Epigenetics, 2011
Background Adenomatous polyposis coli (APC) and Ataxia-telangiectasia-mutated (ATM) gene products have an important role in cell cycle control and maintenance of genomic stability.
Rigi-Ladiz Mohammad, Kordi-Tamandani Dor Mohammad, Torkamanzehi Adam   +2 more
doaj   +1 more source

Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition

Scientific Reports, 2022
A large proportion of colorectal carcinomas (CRC) evolve from colorectal adenomas. However, not all individuals with colonic adenomas have a risk of CRC substantially higher than those of the general population.
Jungwirth Jiri, Urbanova Marketa, Boot Arnoud, Hosek Petr, Bendova Petra, Siskova Anna, Svec Jiri, Kment Milan, Tumova Daniela, Summerova Sandra, Benes Zdenek, Buchler Tomas, Kohout Pavel, Hucl Tomas, Matej Radoslav, Vodickova Ludmila, van Wezel Tom, Vodicka Pavel, Vymetalkova Veronika   +18 more
doaj   +1 more source

Promoter hypermethylation of p16 and APC in gastrointestinal cancer patients

The Turkish Journal of Gastroenterology, 2014
Background/Aims: Cancer is a consequence of the disruption of cellular regulation. Epigenetic is one of the reasons of this disruption. Epigenetic factors play a role in the carcinogenesis by affecting proto-oncogenes and tumor suppressor genes and it is
Beril Erdem, Sibel Küçükyıldırım, Emel Sağlar, Zülfikar Polat, Hatice Mergen   +4 more
doaj   +1 more source

APC Gene Mutations in Human Prostate Cancer [PDF]

Japanese Journal of Clinical Oncology, 1996
Prostate cancer is the most common cancer in aged men. Although ras and p53 gene mutations have been detected in some prostate cancers, the major genetic alterations involved in its carcinogenesis are not well understood. Mutation of the APC gene is responsible for colorectal tumors in which ras and p53 mutations are also often involved. Using PCR-SSCP
M, Watanabe, H, Kakiuchi, H, Kato, T, Shiraishi, R, Yatani, T, Sugimura, M, Nagao   +6 more
openaire   +2 more sources

Somatic Mutation Rate of the APC Gene [PDF]

Japanese Journal of Clinical Oncology, 2001
Somatic inactivation of the wild-type APC gene is involved in the development of adenoma of familial adenomatous polyposis. This situation is also true in sporadic adenomas. It is of biological interest to know the somatic mutation rate of the APC gene.The number of stem cells of the colon (N) and somatic mutation rate of the APC gene in a stem cell in
openaire   +2 more sources

PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling

BMC Bioinformatics, 2010
Background Colon cancer is driven by mutations in a number of genes, the most notorious of which is Apc. Though much of Apc's signaling has been mechanistically identified over the years, it is not always clear which functions or interactions are ...
Patel Vishal, Bebek Gurkan, Chance Mark R   +2 more
doaj   +1 more source

Curated multiple sequence alignment for the Adenomatous Polyposis Coli (APC) gene and accuracy of in silico pathogenicity predictions.

PLoS ONE, 2020
Computational algorithms are often used to assess pathogenicity of Variants of Uncertain Significance (VUS) that are found in disease-associated genes. Most computational methods include analysis of protein multiple sequence alignments (PMSA), assessing ...
Alexander D Karabachev, Dylan J Martini, David J Hermel, Dana Solcz, Marcy E Richardson, Tina Pesaran, Indra Neil Sarkar, Marc S Greenblatt   +7 more
doaj   +1 more source