2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter
Cell Reports, 2017 2-hydroxyglutarate-(2-HG)-mediated inhibition of TET2 activity influences DNA hypermethylation in cells harboring mutations of isocitrate dehydrogenases 1 and 2 (IDH1/2).
Jinmei Xia, Li-Man Hung, Qinxi Li
exaly +3 more sources
Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats
Frontiers in Medicine, 2023 Arsenic (As) exposure is progressively associated with chronic kidney disease (CKD), a leading public health concern present worldwide. The adverse effect of As exposure on the kidneys of people living in As endemic areas have not been extensively ...
Radha Dutt Singh +25 more
doaj +1 more source
Viruses, 2021 Papillomaviruses (PVs) are double-stranded DNA tumour viruses that can infect cutaneous and mucosal epidermis. Human papillomavirus (HPV) types have been linked to the causality of cutaneous squamous cell carcinoma (cSCC); however, HPV DNA is not always ...
Allison M. Tschirley +7 more
doaj +1 more source
Correlation between Promoter Hypermethylation and Expression Profiles of P15INK4b and P16INK4a Genes on Development of Pterygium Disease [PDF]
Journal of Epigenetics, 2021 < p>Background: It is not thoroughly clear that what is the exact etiology of pterygium. Recently, it has been illustrated that pterygium is a benign and destructive condition.
Tahereh Dianat +4 more
doaj +1 more source
Methylation of SPRED1: A New Target in Acute Myeloid Leukemia
Frontiers in Oncology, 2022 Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) has been identified as a novel tumor suppressor gene in acute myeloid leukemia (AML). Previous studies showed that SPRED1 methylation levels were significantly increased in AML patients, making ...
Nan Su +11 more
doaj +1 more source
Genomic and Transcriptomic Alterations Associated with STAT3 Activation in Head and Neck Cancer. [PDF]
, 2016 BackgroundHyperactivation of STAT3 via constitutive phosphorylation of tyrosine 705 (Y705) is common in most human cancers, including head and neck squamous carcinoma (HNSCC).
Gooding, William E +5 more
core +12 more sources
Frontiers in Cell and Developmental Biology, 2021 Prostate cancer (PCa) is the most common malignant tumor affecting males worldwide. The substantial heterogeneity in PCa presents a major challenge with respect to molecular analyses, patient stratification, and treatment.
Enchong Zhang +7 more
doaj +1 more source
The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis
Viruses, 2020 Epstein–Barr-virus-associated Gastric Cancer (EBVaGC) comprises approximately 10% of global gastric cancers and is known to be the most hypermethylated of all tumor types.
Lyla J. Stanland, Micah A. Luftig
doaj +1 more source
Analysis of Promoter Hypermethylation of DAPK and BAX Apoptotic Genes in Iranian Gastric Cancer Patients Undergoing Chemotherapy [PDF]
Middle East Journal of Cancer, 2020 Background: The apoptotic route is mostly damaged in gastric cancer tumor cells. DNA methylation of promoter associated CpG islands inactivates tumor suppressor genes.
Somayeh Nazerian Poudineh +1 more
doaj +1 more source
Pancancer analysis of DNA methylation-driven genes using MethylMix. [PDF]
, 2015 Aberrant DNA methylation is an important mechanism that contributes to oncogenesis. Yet, few algorithms exist that exploit this vast dataset to identify hypo- and hypermethylated genes in cancer.
Gevaert, Olivier +2 more
core +2 more sources