Results 1 to 10 of about 70,635 (144)

Higher Levels of BRCA1 Gene Methylation in Sporadic Breast Cancer Patients with a Lower Incidence of Recurrence [PDF]

Medical Sciences
Background: Breast cancer is the most prevalent malignant disease among women. Here, we investigate whether there is an association between disease recurrence in breast cancer patients and the quantitative methylation pattern of seven genes of different ...
Grasiela Agnes, Andrea Pires Souto Damin, Guilherme Watte, Giuliano Rizzotto Guimarães, Adriana Vial Roehe, Jenifer Saffi   +5 more
doaj   +2 more sources

Prenatal arsenic exposure induces immunometabolic alteration and renal injury in rats

Frontiers in Medicine, 2023
Arsenic (As) exposure is progressively associated with chronic kidney disease (CKD), a leading public health concern present worldwide. The adverse effect of As exposure on the kidneys of people living in As endemic areas have not been extensively ...
Radha Dutt Singh, Radha Dutt Singh, Ratnakar Tiwari, Vineeta Sharma, Vineeta Sharma, Hafizurrahman Khan, Hafizurrahman Khan, Siddhartha Gangopadhyay, Siddhartha Gangopadhyay, Sukhveer Singh, Sukhveer Singh, Kavita Koshta, Kavita Koshta, Shagun Shukla, Nidhi Arjaria, Kapil Mandrah, Kapil Mandrah, Pankaj Ramji Jagdale, Satyakam Patnaik, Satyakam Patnaik, Somendu Kumar Roy, Somendu Kumar Roy, Dhirendra Singh, Ashok Kumar Giri, Vikas Srivastava, Vikas Srivastava   +25 more
doaj   +1 more source

The Mouse Papillomavirus Epigenetic Signature Is Characterised by DNA Hypermethylation after Lesion Regression

Viruses, 2021
Papillomaviruses (PVs) are double-stranded DNA tumour viruses that can infect cutaneous and mucosal epidermis. Human papillomavirus (HPV) types have been linked to the causality of cutaneous squamous cell carcinoma (cSCC); however, HPV DNA is not always ...
Allison M. Tschirley, Peter A. Stockwell, Euan J. Rodger, Oliver Eltherington, Ian M. Morison, Neil Christensen, Aniruddha Chatterjee, Merilyn Hibma   +7 more
doaj   +1 more source

Methylation of SPRED1: A New Target in Acute Myeloid Leukemia

Frontiers in Oncology, 2022
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) has been identified as a novel tumor suppressor gene in acute myeloid leukemia (AML). Previous studies showed that SPRED1 methylation levels were significantly increased in AML patients, making ...
Nan Su, Yujiao Wang, Xianglan Lu, Weihong Xu, He Wang, Wenbin Mo, Hui Pang, Rurong Tang, Shibo Li, Xiaojing Yan, Yan Li, Rui Zhang   +11 more
doaj   +1 more source

Establishment of Novel DNA Methylation-Based Prostate Cancer Subtypes and a Risk-Predicting Eight-Gene Signature

Frontiers in Cell and Developmental Biology, 2021
Prostate cancer (PCa) is the most common malignant tumor affecting males worldwide. The substantial heterogeneity in PCa presents a major challenge with respect to molecular analyses, patient stratification, and treatment.
Enchong Zhang, Fujisawa Shiori, Oscar YongNan Mu, Jieqian He, Yuntian Ge, Hongliang Wu, Mo Zhang, Yongsheng Song   +7 more
doaj   +1 more source

The Role of EBV-Induced Hypermethylation in Gastric Cancer Tumorigenesis

Viruses, 2020
Epstein–Barr-virus-associated Gastric Cancer (EBVaGC) comprises approximately 10% of global gastric cancers and is known to be the most hypermethylated of all tumor types.
Lyla J. Stanland, Micah A. Luftig
doaj   +1 more source

INVESTIGATION OF METHYLATION AND EXPRESSION STATUS OF PAX1 GENE VIA EPIGENOMIC PROFILING IN ORAL MALIGNANT LESIONS

Sabiad, 2022
Introduction: Our previously study (TUBITAK-SBAG-114S497) showed hypermethylation of the PAX1 gene in Turkish oral squamous cell carcinoma (OSCC) patients via methylation-array results.
Arda Öztan, Gülsüm Ak, Murat Ulusan, Semra Demokan   +3 more
doaj   +1 more source

Hypermethylation of Smad7 in CD4+ T cells is associated with the disease activity of rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundSmad7 is protective in a mouse model of rheumatoid arthritis. Here we investigated whether Smad7-expressing CD4+ T cells and the methylation of Smad7 gene in CD4+ T cells contribute to the disease activity of RA in patients.MethodsPeripheral ...
Yiping Hu, Yiping Hu, Bihua Xu, Bihua Xu, Juan He, Juan He, Hongying Shan, Hongying Shan, Gengmin Zhou, Deli Wang, Lu Bai, Hongxi Shang, Liping Nie, Fan Pan, Hui Yao Lan, Hui Yao Lan, Qingwen Wang, Qingwen Wang   +17 more
doaj   +1 more source

Hypermethylation of SHISA3 DNA as a blood-based biomarker for colorectal cancer

Chinese Journal of Physiology, 2021
In Taiwan, colorectal cancer (CRC) is the second most common cancer and the cancer with the third highest mortality rate. This may be because of the difficulty of detecting the disease in the early stages, as well as the fact that colonoscopy, a typical ...
Sheng-Hui Tang, Cheng-Wen Hsiao, Wei-Liang Chen, Li-Wei Wu, Jin-Biou Chang, Bing-Heng Yang   +5 more
doaj   +1 more source

Correlation between Promoter Hypermethylation and Expression Profiles of P15INK4b and P16INK4a Genes on Development of Pterygium Disease [PDF]

Journal of Epigenetics, 2021
< p>Background: It is not thoroughly clear that what is the exact etiology of pterygium. Recently, it has been illustrated that pterygium is a benign and destructive condition.
Tahereh Dianat, Mohammad Naiem Aminifard, Mohammad Arish, Mohammad Hussein Sangtrash, Robab Poyandeh   +4 more
doaj   +1 more source