Epigenetic and antitumor effects of platinum(IV)-octanoato conjugates [PDF]
, 2017 We present the anticancer properties of cis, cis, trans-[Pt(IV)(NH3)2Cl2(OA)2] [Pt(IV)diOA] (OA = octanoato), Pt(IV) derivative of cisplatin containing two OA units appended to the axial positions of a six-coordinate Pt(IV) center.
Brabec, Viktor +8 more
core +1 more source
No SMAD4 hypermethylation in colorectal cancer [PDF]
British Journal of Cancer, 2000 The chromosome region 18q21 is frequently deleted in colorectal cancers. Three candidate tumour suppressor genes, DCC, SMAD4 and SMAD2, map to this region. The SMAD4(DPC4) gene was recently identified as a candidate pancreatic cancer suppressor gene. It is also a gene for juvenile polyposis tumour predisposition syndrome.
Roth, S +4 more
openaire +2 more sources
Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives [PDF]
, 2019 Oral cancer is the sixth most common cancer type in the world, and 90% of it is represented by oral squamous cell carcinoma (OSCC). Despite progress in preventive and therapeutic strategies, delay in OSCC diagnosis remains one of the major causes of high
Campisi, Giuseppina +5 more
core +1 more source
Functional Analysis of in Vivo and in Organello Footprinting of HeLa Cell Mitochondrial DNA in Relationship to ATP and Ethidium Bromide Effects on Transcription [PDF]
, 1997 In vivo and in organello footprinting techniques based on methylation interference have been utilized to investigate protein-DNA interactions in the transcription initiation and rDNA transcription termination regions of human mitochondrial DNA (mtDNA) in
Attardi, Giuseppe +2 more
core +1 more source
Diagnostic Value of RASSF1A gene DNA methylation in Differential Diagnosis of Thyroid Benign Tumors and Papillary Thyroid Carcinoma [PDF]
Journal of Epigenetics, 2019 Thyroid cancer is the most common endocrine malignancy that its incidence hascontinuously increased in recent decades all over the world. Thyroid cancer in Iranis the seventh most common cancer in women and the 14th in men and the 11th mostcommon cancer ...
Gholamabbas Dinarvand +2 more
doaj +1 more source
Epigenetic Modulation Directs Recovery Post LASIK and SMILE Surgery: An Experimental Study
LifePurpose: refractive surgery, such as LASIK and SMILE, induces a wound healing response that leads to significant corneal stromal remodeling. We have shown that the protein profile in the stroma changes dramatically immediately post-surgery.
Rohit Shetty +6 more
doaj +1 more source
Exaggerated CpH methylation in the autism-affected brain. [PDF]
, 2017 BackgroundThe etiology of autism, a complex, heritable, neurodevelopmental disorder, remains largely unexplained. Given the unexplained risk and recent evidence supporting a role for epigenetic mechanisms in the development of autism, we explored the ...
Arking, Dan E +4 more
core +1 more source
Frontiers in Genetics, 2013 The growing fetus is dependent on adequate placental function for delivery of essential nutrients and oxygen, and for waste removal. The placenta also plays an important protective role; shielding the developing baby from the maternal immune system and ...
Boris eNovakovic +2 more
doaj +1 more source
AZT‐induced hypermethylation of human thymidine kinase gene in the absence of total DNA hypermethylation [PDF]
FEBS Letters, 1996 Genome‐wide DNA hypermethylation induced by 3′‐azido‐3′‐deoxythymidine (AZT) has been suggested to be involved in the development of AZT resistance. We used a CD4 T‐lymphoblastoid CEM line and its AZT‐resistant MT500 variant with reduced thymidine kinase activity.
LUCARELLI, Marco +6 more
openaire +2 more sources
Frontiers in Oncology, 2021 Helicobacter pylori infection has been associated with the onset of gastric mucosal inflammation and is known to perturb the balance between T-regulatory (Treg) and T-helper 17 (Th17) cells which causes a spurt of interleukin 17 (IL17) and transforming ...
Iqra Jan +10 more
doaj +1 more source