Results 41 to 50 of about 70,734 (243)

E-Cadherin Downregulation is Mediated by Promoter Methylation in Canine Prostate Cancer

Frontiers in Genetics, 2019
E-cadherin is a transmembrane glycoprotein responsible for cell-to-cell adhesion, and its loss has been associated with metastasis development. Although E-cadherin downregulation was previously reported in canine prostate cancer (PC), the mechanism ...
Carlos Eduardo Fonseca-Alves, Carlos Eduardo Fonseca-Alves, Priscila Emiko Kobayashi, Antonio Fernando Leis-Filho, Patricia de Faria Lainetti, Valeria Grieco, Hellen Kuasne, Silvia Regina Rogatto, Renee Laufer-Amorim   +8 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Hypermethylation Effects of Yiqihuoxue Decoction in Diabetic Atherosclerosis Using Genome-Wide DNA Methylation Analyses

Journal of Inflammation Research, 2022
Qing-Bing Zhou,1 Yao Chen,1 Yan Zhang,1 Dan-Dan Li,1 Hong-Qin Wang,1 Zi-Jun Jia,1 Yu Jin,2 Feng-Qin Xu,1 Ying Zhang1 1Institute of Geriatric Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, People’s Republic of China;
Zhou QB, Chen Y, Zhang Y, Li DD, Wang HQ, Jia ZJ, Jin Y, Xu FQ, Zhang Y   +8 more
doaj  

Promoter Hypermethylation Profile of Kidney Cancer [PDF]

Clinical Cancer Research, 2004
Abstract Purpose: Promoter hypermethylation is an important mechanism of inactivation of tumor suppressor genes in cancer cells. Kidney tumors are heterogeneous in their histology, genetics, and clinical behavior. To gain insight into the role of epigenetic silencing of tumor suppressor and cancer genes in kidney tumorigenesis, we ...
Essel, Dulaimi, Inmaculada, Ibanez de Caceres, Robert G, Uzzo, Tahseen, Al-Saleem, Richard E, Greenberg, Thomas J, Polascik, James S, Babb, William E, Grizzle, Paul, Cairns   +8 more
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

NR3C1 hypermethylation in depressed and bullied adolescents [PDF]

Translational Psychiatry, 2018
AbstractThe disruption of key epigenetic processes during critical periods of brain development can increase an individual’s vulnerability to psychopathology later in life. For instance, DNA methylation in the glucocorticoid receptor gene (NR3C1) in adulthood is known to be associated with early-life adversities and has been suggested to mediate the ...
Paschalis Efstathopoulos, Filip Andersson, Philippe A. Melas, Liu L. Yang, J. Carlos Villaescusa, Joëlle Rȕegg, Tomas J. Ekström, Yvonne Forsell, Maria Rosaria Galanti, Catharina Lavebratt   +9 more
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Hypermethylation of RAD9A intron 2 in childhood cancer patients, leukemia and tumor cell lines suggest a role for oncogenic transformation

EXCLI Journal : Experimental and Clinical Sciences, 2022
Most childhood cancers occur sporadically and cannot be explained by an inherited mutation or an unhealthy lifestyle. However, risk factors might trigger the oncogenic transformation of cells.
Danuta Galetzka, Julia Böck, Lukas Wagner, Marcus Dittrich, Olesja Sinizyn, Marco Ludwig, Heidi Rossmann, Claudia Spix, Markus Radsak, Peter Scholz-Kreisel, Johanna Mirsch, Matthias Linke, Walburgis Brenner, Manuela Marron, Alicia Poplawski, Thomas Haaf, Heinz Schmidberger, Dirk Prawitt   +17 more
doaj   +1 more source

Hypermethylation of the RUNX3 gene in hepatocellular carcinoma [PDF]

Experimental & Molecular Medicine, 2005
Methylation events play a critical role in various cellular processes including regulation of gene transcription and proliferation. Recently, RUNX3 gene, one of TGF-beta-Smads signaling transduction pathway genes, showed strong tumor-suppressor activity by regulation of epithelial proliferation and apoptosis. To elucidate the potential etiological role
Won Sang, Park, Yong Gu, Cho, Chang Jae, Kim, Jae Hwi, Song, Youn Soo, Lee, Su Young, Kim, Suk Woo, Nam, Sug Hyung, Lee, Nam Jin, Yoo, Jung Young, Lee   +9 more
openaire   +2 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source