Results 21 to 30 of about 116,541 (302)

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

INVESTIGATION OF METHYLATION AND EXPRESSION STATUS OF PAX1 GENE VIA EPIGENOMIC PROFILING IN ORAL MALIGNANT LESIONS

Sabiad, 2022
Introduction: Our previously study (TUBITAK-SBAG-114S497) showed hypermethylation of the PAX1 gene in Turkish oral squamous cell carcinoma (OSCC) patients via methylation-array results.
Arda Öztan, Gülsüm Ak, Murat Ulusan, Semra Demokan   +3 more
doaj   +1 more source

FHL2 regulates hematopoietic stem cell functions under stress conditions. [PDF]

, 2015
FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under ...
Chen, J, Fan, R, Hou, Y, Hou, Y, Jiang, Y, Li, L, Li, W, Mittal, N, Peace, D, Qian, Z, Wang, X, Wu, W, Zhu, T   +12 more
core   +2 more sources

Genomic sweeping for hypermethylated genes [PDF]

Bioinformatics, 2006
AbstractMotivation: Genes silenced by the aberrent methylation of nearby CpG islands can contribute to the onset or progression of cancer and represent potential biomarkers for diagnosis and prognosis. Relatively few have thus far been validated as hypermethylated in cancer among over 14 000 candidates with promoter region CpG islands.
Liang Goh, Susan K. Murphy, Sayan Mukherjee 0001, Terrence S. Furey   +3 more
openaire   +2 more sources

Hypermethylation of Smad7 in CD4+ T cells is associated with the disease activity of rheumatoid arthritis

Frontiers in Immunology, 2023
BackgroundSmad7 is protective in a mouse model of rheumatoid arthritis. Here we investigated whether Smad7-expressing CD4+ T cells and the methylation of Smad7 gene in CD4+ T cells contribute to the disease activity of RA in patients.MethodsPeripheral ...
Yiping Hu, Yiping Hu, Bihua Xu, Bihua Xu, Juan He, Juan He, Hongying Shan, Hongying Shan, Gengmin Zhou, Deli Wang, Lu Bai, Hongxi Shang, Liping Nie, Fan Pan, Hui Yao Lan, Hui Yao Lan, Qingwen Wang, Qingwen Wang   +17 more
doaj   +1 more source

Plants regenerated from tissue culture contain stable epigenome changes in rice. [PDF]

, 2013
Most transgenic crops are produced through tissue culture. The impact of utilizing such methods on the plant epigenome is poorly understood. Here we generated whole-genome, single-nucleotide resolution maps of DNA methylation in several regenerated rice ...
Bellizzi, Maria, Ding, Bo, Feng, Suhua, Jacobsen, Steven E, Meyers, Blake C, Pellegrini, Matteo, Simon, Stacey A, Stroud, Hume, Wang, Guo-Liang   +8 more
core   +2 more sources

Colorectal Cancer & Molecular Mutations and Polymorphism

Frontiers in Oncology, 2013
Colorectal cancer (CRC) is one of the major causes of mortality and morbidity, and is the third most common cancer in men and the second most common cancer in women worldwide. The incidence of CRC shows considerable variation among racially or ethnically
Aga Syed Sameer
doaj   +1 more source

Reelin promoter hypermethylation in schizophrenia [PDF]

Proceedings of the National Academy of Sciences, 2005
Reelin mRNA and protein levels are reduced by ≈50% in various cortical structures of postmortem brain from patients diagnosed with schizophrenia or bipolar illness with psychosis. In addition, the mRNA encoding the methylating enzyme, DNA methyltransferase 1, is up-regulated in the same neurons that coexpress reelin and glutamic acid decarboxylase 67 ...
Dennis R, Grayson, Xiaomei, Jia, Ying, Chen, Rajiv P, Sharma, Colin P, Mitchell, Alessandro, Guidotti, Erminio, Costa   +6 more
openaire   +2 more sources

Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

Human Genomics, 2011
The development and progression of colorectal cancer (CRC) is a multi-step process, and the Wnt pathways with its two molecular gladiators adenomatous polyposis coli (APC) and β-catenin plays an important role in transforming a normal tissue into a ...
Sameer A, Shah Zaffar A, Abdullah Safiya, Chowdri Nissar A, Siddiqi Mushtaq A   +4 more
doaj   +1 more source

Hypermethylation of SHISA3 DNA as a blood-based biomarker for colorectal cancer

Chinese Journal of Physiology, 2021
In Taiwan, colorectal cancer (CRC) is the second most common cancer and the cancer with the third highest mortality rate. This may be because of the difficulty of detecting the disease in the early stages, as well as the fact that colonoscopy, a typical ...
Sheng-Hui Tang, Cheng-Wen Hsiao, Wei-Liang Chen, Li-Wei Wu, Jin-Biou Chang, Bing-Heng Yang   +5 more
doaj   +1 more source