Results 21 to 30 of about 70,734 (243)

Case report: biallelic DNMT3A mutations in acute myeloid leukemia

Frontiers in Oncology, 2023
DNMT3A gene mutations, detected in 20-25% of de novo acute myeloid leukemia (AML) patients, are typically heterozygous. Biallelic variants are uncommon, affecting ~3% of cases and identifying a worse prognosis.
Cosimo Cumbo, Paola Orsini, Luisa Anelli, Antonella Zagaria, Maria Federica Iannò, Loris De Cecco, Crescenzio Francesco Minervini, Nicoletta Coccaro, Giuseppina Tota, Elisa Parciante, Maria Rosa Conserva, Immacolata Redavid, Francesco Tarantini, Angela Minervini, Paola Carluccio, Anna De Grassi, Ciro Leonardo Pierri, Giorgina Specchia, Pellegrino Musto, Francesco Albano   +19 more
doaj   +1 more source

Genomic sweeping for hypermethylated genes [PDF]

Bioinformatics, 2006
AbstractMotivation: Genes silenced by the aberrent methylation of nearby CpG islands can contribute to the onset or progression of cancer and represent potential biomarkers for diagnosis and prognosis. Relatively few have thus far been validated as hypermethylated in cancer among over 14 000 candidates with promoter region CpG islands.
Liang Goh, Susan K. Murphy, Sayan Mukherjee 0001, Terrence S. Furey   +3 more
openaire   +2 more sources

Colorectal Cancer & Molecular Mutations and Polymorphism

Frontiers in Oncology, 2013
Colorectal cancer (CRC) is one of the major causes of mortality and morbidity, and is the third most common cancer in men and the second most common cancer in women worldwide. The incidence of CRC shows considerable variation among racially or ethnically
Aga Syed Sameer
doaj   +1 more source

Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

Human Genomics, 2011
The development and progression of colorectal cancer (CRC) is a multi-step process, and the Wnt pathways with its two molecular gladiators adenomatous polyposis coli (APC) and β-catenin plays an important role in transforming a normal tissue into a ...
Sameer A, Shah Zaffar A, Abdullah Safiya, Chowdri Nissar A, Siddiqi Mushtaq A   +4 more
doaj   +1 more source

No SMAD4 hypermethylation in colorectal cancer [PDF]

British Journal of Cancer, 2000
The chromosome region 18q21 is frequently deleted in colorectal cancers. Three candidate tumour suppressor genes, DCC, SMAD4 and SMAD2, map to this region. The SMAD4(DPC4) gene was recently identified as a candidate pancreatic cancer suppressor gene. It is also a gene for juvenile polyposis tumour predisposition syndrome.
Roth, S, Laiho, P, Salovaara, R, Launonen, V, Aaltonen, L A   +4 more
openaire   +2 more sources

Analysis of Promoter Hypermethylation of DAPK and BAX Apoptotic Genes in Iranian Gastric Cancer Patients Undergoing Chemotherapy [PDF]

Middle East Journal of Cancer, 2020
Background: The apoptotic route is mostly damaged in gastric cancer tumor cells. DNA methylation of promoter associated CpG islands inactivates tumor suppressor genes.
Somayeh Nazerian Poudineh, Golnaz Asaadi Tehrani   +1 more
doaj   +1 more source

Epigenetic Modulation Directs Recovery Post LASIK and SMILE Surgery: An Experimental Study

Life
Purpose: refractive surgery, such as LASIK and SMILE, induces a wound healing response that leads to significant corneal stromal remodeling. We have shown that the protein profile in the stroma changes dramatically immediately post-surgery.
Rohit Shetty, Pooja Khamar, Ramaraj Kannan, Puja Thacker, Nimisha Rajiv Kumar, Arkasubhra Ghosh, Vrushali Deshpande   +6 more
doaj   +1 more source

AZT‐induced hypermethylation of human thymidine kinase gene in the absence of total DNA hypermethylation [PDF]

FEBS Letters, 1996
Genome‐wide DNA hypermethylation induced by 3′‐azido‐3′‐deoxythymidine (AZT) has been suggested to be involved in the development of AZT resistance. We used a CD4 T‐lymphoblastoid CEM line and its AZT‐resistant MT500 variant with reduced thymidine kinase activity.
LUCARELLI, Marco, PALITTI, Franco, CAROTTI, Daniela, Maurizio Cianfriglia, Claudia Signoretti, BOZZI, Argante, STROM, Roberto   +6 more
openaire   +2 more sources

European guidelines from the EHTG and ESCP for Lynch syndrome: an updated third edition of the Mallorca guidelines based on gene and gender

BJS (British Journal of Surgery), EarlyView., 2020
Recommendations for clinical and molecular identification of LS, surgical and endoscopic management of LS‐associated colorectal cancer and preventive measures for cancer were produced. The emphasis was on surgical and gastroenterological aspects of the cancer spectrum.
T. T. Seppälä, A. Latchford, I. Negoi, A. Sampaio Soares, R. Jimenez‐Rodriguez, L. Sánchez‐Guillén, D. G. Evans, N. Ryan, E. J. Crosbie, M. Dominguez‐Valentin, J. Burn, M. Kloor, M. von Knebel Doeberitz, F. J. B. van Duijnhoven, P. Quirke, J. R. Sampson, P. Møller, G. Möslein, on behalf of the European Hereditary Tumour Group (EHTG) and European Society of Coloproctology (ESCP)   +18 more
wiley   +1 more source

Hypermethylation of genes in testicular embryonal carcinomas [PDF]

British Journal of Cancer, 2015
Testicular embryonal carcinoma (EC) is a major subtype of non-seminomatous germ cell tumours in males. Embryonal carcinomas are pluripotent, undifferentiated germ cell tumours believed to originate from primordial germ cells. Epigenetic changes during testicular EC tumorigenesis require better elucidation.To identify epigenetic changes during ...
Cheung, Hoi-Hung, Yang, Yanzhou, Lee, Tin-Lap, Rennert, Owen, Chan, Wai-Yee   +4 more
openaire   +2 more sources