Results 11 to 20 of about 70,734 (243)
Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese
Journal of Research in Medical Sciences, 2020 Background: DNA methylation was considered to play an important role in hypertension. However, the direct association between dihydrofolate reductase (DHFR) promoter methylation and hypertension remains unclear.
Guodong Xu +10 more
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Neoplasia: An International Journal for Oncology Research, 2005 An unselected series of 310 colorectal carcinomas, stratified according to microsatellite instability (MSI) and DNA ploidy, was examined for mutations and/or promoter hypermethylation of five components of the WNT signaling cascade [APC, CTNNB1 (encoding
Lin Thorstensen +6 more
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Diagnostic Value of RASSF1A gene DNA methylation in Differential Diagnosis of Thyroid Benign Tumors and Papillary Thyroid Carcinoma [PDF]
Journal of Epigenetics, 2019 Thyroid cancer is the most common endocrine malignancy that its incidence hascontinuously increased in recent decades all over the world. Thyroid cancer in Iranis the seventh most common cancer in women and the 14th in men and the 11th mostcommon cancer ...
Gholamabbas Dinarvand +2 more
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Dissecting DNA hypermethylation in cancer [PDF]
FEBS Letters, 2010 There is compelling evidence to support the importance of DNA methylation alterations in cancer development. Both losses and gains of DNA methylation are observed, thought to contribute pathophysiologically by inactivating tumor suppressor genes, inducing chromosomal instability and ectopically activating gene expression. Lesser known are the causes of
Estécio, Marcos R.H. +1 more
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Neoplasia: An International Journal for Oncology Research, 2005 We examined the promoter hypermethylation of tumorsuppressor genes RASSF1A, TSLC1, quantitated EBV DNA load in nasopharyngeal carcinoma (NPC) tissues (T tissues), matched tumor-adjacent tissues outside 0.5 cm (P tissues), outside 1.0 cm (Z tissues) to ...
Liang Zhou +7 more
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Frontiers in Oncology, 2021 Helicobacter pylori infection has been associated with the onset of gastric mucosal inflammation and is known to perturb the balance between T-regulatory (Treg) and T-helper 17 (Th17) cells which causes a spurt of interleukin 17 (IL17) and transforming ...
Iqra Jan +10 more
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DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin’s Lymphomas
Frontiers in Genetics, 2012 In addition to histone modification, DNA methylation is the other form of epigenetic alteration leading to heritable phenotypic changes of cells with functional consequences.
Rita Lok Hay Yim +4 more
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The promoter hypermethylation of SULT2B1 accelerates esophagus tumorigenesis via downregulated PER1
Thoracic Cancer, 2021 Background Esophageal cancer is currently the eighth most common tumor in the world and a leading cause of cancer death. SULT2B1 plays crucial roles in tumorigenesis. The purpose of this study is to explore the role of SULT2B1 in esophageal squamous cell
Zhuo Li +8 more
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Reelin promoter hypermethylation in schizophrenia [PDF]
Proceedings of the National Academy of Sciences, 2005 Reelin mRNA and protein levels are reduced by ≈50% in various cortical structures of postmortem brain from patients diagnosed with schizophrenia or bipolar illness with psychosis. In addition, the mRNA encoding the methylating enzyme, DNA methyltransferase 1, is up-regulated in the same neurons that coexpress reelin and glutamic acid decarboxylase 67 ...
Dennis R, Grayson +6 more
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2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter
Cell Reports, 2017 2-hydroxyglutarate-(2-HG)-mediated inhibition of TET2 activity influences DNA hypermethylation in cells harboring mutations of isocitrate dehydrogenases 1 and 2 (IDH1/2).
Zhentao Yang +11 more
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