Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes. [PDF]
, 2017 ObjectiveTo determine whether differentially methylated CpGs in synovium-derived fibroblast-like synoviocytes (FLS) of patients with rheumatoid arthritis (RA) were also differentially methylated in RA peripheral blood (PB) samples.MethodsFor this study ...
Barcellos, Lisa F +16 more
core +1 more source
Hypermethylation of dihydrofolate reductase promoter increases the risk of hypertension in Chinese
Journal of Research in Medical Sciences, 2020 Background: DNA methylation was considered to play an important role in hypertension. However, the direct association between dihydrofolate reductase (DHFR) promoter methylation and hypertension remains unclear.
Guodong Xu +10 more
doaj +1 more source
Genome-wide methylome analysis using MethylCap-seq uncovers 4 hypermethylated markers with high sensitivity for both adeno- and squamous-cell cervical carcinoma [PDF]
, 2016 Background: Cytology-based screening methods for cervical adenocarcinoma (ADC) and to a lesser extent squamous-cell carcinoma (SCC) suffer from low sensitivity.
Boers, Aniek +9 more
core +2 more sources
Neoplasia: An International Journal for Oncology Research, 2005 An unselected series of 310 colorectal carcinomas, stratified according to microsatellite instability (MSI) and DNA ploidy, was examined for mutations and/or promoter hypermethylation of five components of the WNT signaling cascade [APC, CTNNB1 (encoding
Lin Thorstensen +6 more
doaj +1 more source
Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma [PDF]
, 2015 We thank Professors Michael Rehli, Yoshiaki Ito, and Kristian Helin for gifting plasmids, Dr. Alasdair MacKenzie (University of Aberdeen) for helpful discussion, and Mr. Takashi Mizukami, Ms. Ryoko Tokuda, and Ms.
Mizokami, Atsushi +6 more
core +1 more source
Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. [PDF]
, 2014 BackgroundSince tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically.
Aldaz, Marcelo +8 more
core +3 more sources
Dissecting DNA hypermethylation in cancer [PDF]
FEBS Letters, 2010 There is compelling evidence to support the importance of DNA methylation alterations in cancer development. Both losses and gains of DNA methylation are observed, thought to contribute pathophysiologically by inactivating tumor suppressor genes, inducing chromosomal instability and ectopically activating gene expression. Lesser known are the causes of
Estécio, Marcos R.H. +1 more
openaire +2 more sources
Neoplasia: An International Journal for Oncology Research, 2005 We examined the promoter hypermethylation of tumorsuppressor genes RASSF1A, TSLC1, quantitated EBV DNA load in nasopharyngeal carcinoma (NPC) tissues (T tissues), matched tumor-adjacent tissues outside 0.5 cm (P tissues), outside 1.0 cm (Z tissues) to ...
Liang Zhou +7 more
doaj +1 more source
Analysis of the machinery and intermediates of the 5hmC-mediated DNA demethylation pathway in aging on samples from the MARKAGE Study [PDF]
, 2016 Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in ...
Bacalini, Maria Giulia +24 more
core +2 more sources
DNA Methylation of Tumor Suppressive miRNAs in Non-Hodgkin’s Lymphomas
Frontiers in Genetics, 2012 In addition to histone modification, DNA methylation is the other form of epigenetic alteration leading to heritable phenotypic changes of cells with functional consequences.
Rita Lok Hay Yim +4 more
doaj +1 more source