Results 11 to 20 of about 155,361 (266)

APC coordinates GSK3 phosphorylation of SETD8 to suppress colorectal cancer [PDF]

Cell Reports
Summary: Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths. Mutations in the tumor-suppressor APC initiate CRC in part by preventing the glycogen synthase kinase 3 (GSK3) kinase from phosphorylating β-CATENIN, leading to its ...
Zvi Cramer, Keara Monaghan, Ricardo Petroni, Xin Wang, Stephanie Adams-Tzivelekidis, Kayla Durning, Melissa S. Kim, Yuhua Tian, Nicolette M. Johnson, María F. Carrera Rodríguez, Xiaoyuan Gao, Nicolae A. Leu, Simone Sidoli, Ning O. Li, M. Andres Blanco, Christopher J. Lengner   +15 more
doaj   +2 more sources

To Identify Adenomatous Polyposis Coli Gene Mutation as a Predictive Marker of Endometrial Cancer Immunotherapy

Frontiers in Cell and Developmental Biology, 2022
The adenomatous polyposis coli (APC) gene is the chromatin-remodeling-related gene and a typical tumor suppressor. Patients with a high expression of programmed death-ligand 1 (PD-L1) or a high level of tumor mutational burden (TMB) may benefit from ...
Yunfeng Song, Jian Huang, Kai Wang, Yiran Li, Yiran Li   +4 more
doaj   +1 more source

Prediction and testing of biological networks underlying intestinal cancer. [PDF]

PLoS ONE, 2010
Colorectal cancer progresses through an accumulation of somatic mutations, some of which reside in so-called "driver" genes that provide a growth advantage to the tumor.
Vishal N Patel, Gurkan Bebek, John M Mariadason, Donghai Wang, Leonard H Augenlicht, Mark R Chance   +5 more
doaj   +1 more source

Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium. [PDF]

PLoS Genetics, 2015
Adenomatous polyposis coli (APC) inactivating mutations are present in most human colorectal cancers and some other cancers. The APC protein regulates the β-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated ...
Ying Feng, Naoya Sakamoto, Rong Wu, Jie-Yu Liu, Alexandra Wiese, Maranne E Green, Megan Green, Aytekin Akyol, Badal C Roy, Yali Zhai, Kathleen R Cho, Eric R Fearon   +11 more
doaj   +1 more source

Meningiomas exhibit loss of heterozygosity of the APC gene [PDF]

Journal of Neuro-Oncology, 2007
The molecular mechanisms and candidate genes involved in development of meningiomas still need investigation and elucidation. In the present study 33 meningiomas were analyzed regarding genetic changes of tumor suppressor gene Adenomatous polyposis coli (APC), a component of the wnt signaling.
Pećina-Šlaus, Nives, Nikuševa Martić, Tamara, Tomas, Davor, Beroš, Vili, Zeljko, Martina, Čupić, Hrvoje   +5 more
openaire   +9 more sources

Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer. [PDF]

PLoS ONE, 2011
Aberrant activation of the Wnt/β-catenin pathway is critical for the initiation and progression of most colon cancers. This activation provokes the accumulation of nuclear β-catenin and the induction of its target genes.
María Jesús Larriba, Paloma Ordóñez-Morán, Irene Chicote, Génesis Martín-Fernández, Isabel Puig, Alberto Muñoz, Héctor G Pálmer   +6 more
doaj   +1 more source

Adenomatous Polyposis Coli loss controls cell cycle regulators and response to paclitaxel in MDA-MB-157 metaplastic breast cancer cells.

PLoS ONE, 2021
Adenomatous Polyposis Coli (APC) is lost in approximately 70% of sporadic breast cancers, with an inclination towards triple negative breast cancer (TNBC).
Emily M Astarita, Sara M Maloney, Camden A Spring, Bronwyn J Berkeley, Monica K VanKlompenberg, T Murlidharan Nair, Jenifer R Prosperi   +6 more
doaj   +2 more sources

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene [PDF]

Human Molecular Genetics, 1992
We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients. In addition to loss of heterozygosity (LOH) at the APC locus in 30 tumors, 43 other somatic mutations were detected.
Y, Miyoshi, H, Nagase, H, Ando, A, Horii, S, Ichii, S, Nakatsuru, T, Aoki, Y, Miki, T, Mori, Y, Nakamura   +9 more
openaire   +2 more sources

CD24 and APC Genetic Polymorphisms in Pancreatic Cancers as Potential Biomarkers for Clinical Outcome. [PDF]

PLoS ONE, 2015
There are no validated biomarkers that correlate with the prognosis of pancreatic ductal adenocarcinoma (PDA). The CD24 and adenomatous polyposis coli (APC) genes are important in the malignant transformation of gastrointestinal cells.
Sivan Shamai, Ilana Nabiochtchikov, Sarah Kraus, Sally Zigdon, Dina Kazanov, Michal Itzhak-Klutch, Carmit Eizner, Nadir Arber, Ravit Geva   +8 more
doaj   +1 more source

Genomic alterations in the WNT/β-catenin pathway and resistance of colorectal cancer cells to pathway-targeting therapies [PDF]

Exploration of Targeted Anti-tumor Therapy
Aim: Colorectal cancer is the most prevalent gastrointestinal malignancy with limited therapeutic options in the metastatic setting. The WNT/β-catenin/adenomatous polyposis coli (APC) pathway is commonly deregulated in the disease and presents a rational
Ioannis A. Voutsadakis
doaj   +1 more source