CD24 and APC Genetic Polymorphisms in Pancreatic Cancers as Potential Biomarkers for Clinical Outcome. [PDF]
PLoS ONE, 2015 There are no validated biomarkers that correlate with the prognosis of pancreatic ductal adenocarcinoma (PDA). The CD24 and adenomatous polyposis coli (APC) genes are important in the malignant transformation of gastrointestinal cells.
Sivan Shamai +8 more
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Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]
, 2002 Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
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Wnt signalling in intestinal stem cells: lessons from mice and flies [PDF]
, 2018 Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeostasis, and in tissue regeneration following damage. The highly conserved Wnt signalling pathway is a key regulator of stem cell fate.
Carroll, Lynsey +2 more
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Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells
Genomics Data, 2016 The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in about 80% of colorectal cancers (CRC) Brannon et al. (2014) [1]. APC is a large multifunctional protein that regulates many biological functions including Wnt signalling (through ...
Lauren E. King +4 more
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E-cadherin can limit the transforming properties of activating β-catenin mutations [PDF]
, 2015 Wnt pathway deregulation is a common characteristic of many cancers. But only Colorectal Cancer predominantly harbours mutations in APC, whereas other cancer types (hepatocellular carcinoma, solid pseudopapillary tumours of pancreas) have activating ...
Alan R Clarke +27 more
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Mutational analysis of driver genes defines the colorectal adenoma: in situ carcinoma transition
Scientific Reports, 2022 A large proportion of colorectal carcinomas (CRC) evolve from colorectal adenomas. However, not all individuals with colonic adenomas have a risk of CRC substantially higher than those of the general population.
Jungwirth Jiri +18 more
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Case Report: Coinheritance of Germline Mutations in APC and BRCA1 in Colorectal Cancer
Frontiers in Oncology, 2021 Deleterious mutations in APC gene cause the autosomal dominant familial adenomatous polyposis (FAP) which is typically characterized by the occurrence of hundreds to thousands of colorectal adenomas that eventually lead to colorectal cancers (CRCs ...
Wei Huang +6 more
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Absolute quantitation of DNA methylation of 28 candidate genes in prostate cancer using pyrosequencing [PDF]
, 2011 This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Aberrant DNA methylation plays a pivotal
Beltran, L +14 more
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Clinical Epigenetics, 2011 Background Adenomatous polyposis coli (APC) and Ataxia-telangiectasia-mutated (ATM) gene products have an important role in cell cycle control and maintenance of genomic stability.
Rigi-Ladiz Mohammad +2 more
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BMC Genomics, 2021 Background Familial adenomatous polyposis is an inherited genetic disease, characterized by colorectal polyps. It is caused by inactivating mutations in the Adenomatous polyposis coli (Apc) gene. Mice carrying a nonsense mutation in the Apc gene at R850,
Alexandra Dorman +6 more
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