Promoter hypermethylation of p16 and APC in gastrointestinal cancer patients
The Turkish Journal of Gastroenterology, 2014 Background/Aims: Cancer is a consequence of the disruption of cellular regulation. Epigenetic is one of the reasons of this disruption. Epigenetic factors play a role in the carcinogenesis by affecting proto-oncogenes and tumor suppressor genes and it is
Beril Erdem +4 more
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Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer [PDF]
, 2014 Background: Aberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer.
Alizadeh-Navaei, R. +4 more
core +1 more source
p53 and APC gene mutations: software and databases [PDF]
Nucleic Acids Research, 1997 A large number of different mutations in the APC and p53 tumor suppressor genes have been identified in various types of cancer. This substantial increase since our previous reports can enable analyses which were not previously possible. In order to capture all these new data, the software permitting analysis has been improved.
C, Béroud, T, Soussi
openaire +2 more sources
PLoS ONE, 2020 Computational algorithms are often used to assess pathogenicity of Variants of Uncertain Significance (VUS) that are found in disease-associated genes. Most computational methods include analysis of protein multiple sequence alignments (PMSA), assessing ...
Alexander D Karabachev +7 more
doaj +1 more source
Recurrent APC gene mutations in Polish FAP families [PDF]
Hereditary Cancer in Clinical Practice, 2007 The molecular diagnostics of genetically conditioned disorders is based on the identification of the mutations in the predisposing genes. Hereditary cancer disorders of the gastrointestinal tracts are caused by mutations of the tumour suppressor genes or the DNA repair genes. Occurrence of recurrent mutation allows improvement of molecular diagnostics.
Pławski Andrzej +2 more
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PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling
BMC Bioinformatics, 2010 Background Colon cancer is driven by mutations in a number of genes, the most notorious of which is Apc. Though much of Apc's signaling has been mechanistically identified over the years, it is not always clear which functions or interactions are ...
Patel Vishal +2 more
doaj +1 more source
The Anaphase-Promoting Complex (APC) ubiquitin ligase affects chemosensory behavior in \u3cem\u3eC. elegans\u3c/em\u3e [PDF]
, 2016 The regulation of fundamental aspects of neurobiological function has been linked to the ubiquitin signaling system (USS), which regulates the degradation and activity of proteins and is catalyzed by E1, E2, and E3 enzymes. The Anaphase-Promoting Complex
Jennings, Alexandra K. +2 more
core +3 more sources
Methylation of multiple genes in hepatitis C virus associated hepatocellular carcinoma
Journal of Advanced Research, 2014 We studied promoter methylation (PM) of 11 genes in Peripheral Blood Lymphocytes (PBLs) and tissues of hepatitis C virus (HCV) associated hepatocellular carcinoma (HCC) and chronic hepatitis (CH) Egyptian patients.
Abdel-Rahman N. Zekri +8 more
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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene [PDF]
Human Molecular Genetics, 1992 We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients. In addition to loss of heterozygosity (LOH) at the APC locus in 30 tumors, 43 other somatic mutations were detected.
Y, Miyoshi +9 more
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Influence of some methylated hepatocarcinogenesis-related genes on the response to antiviral therapy and development of fibrosis in chronic hepatitis C patients [PDF]
Clinical and Molecular Hepatology, 2020 Background and Aim Epigenetics involved in multiple normal cellular processes. Previous research have revealed the role of hepatitis C virus infection in accelerating methylation process and affecting response to treatment in chronic hepatitis patients ...
Waleed Seif Eldin Mohamed Mostafa +5 more
doaj +1 more source