Results 31 to 40 of about 156,482 (265)

Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3β and APC and Inhibiting Gene β-Catenin

Journal of Analytical Methods in Chemistry, 2013
Objective. Inhibiting gene β-catenin and inducting genes GSK-3β and APC, promoting the tumor cell apoptosis in Wnt pathway, by chlorogenic acid were discussed (CGA). Method. The different genes were scanned by the 4*44K mouse microarray chips.
Ruoshi Xu, Qiumei Kang, Jie Ren, Zukun Li, Xiaoping Xu   +4 more
doaj   +1 more source

Two Steps Methylation Specific PCR for Assessment of APC Promoter Methylation in Gastric Adenocarcinoma [PDF]

Journal of Sciences, Islamic Republic of Iran, 2011
Gastric Cancer (GC) is the second most common cancer in the world and a leading cause of cancer-related mortality. Methylation of promoter CpG islands (CGIs) belonging to tumor suppressor genes causes transcriptional silencing of their corresponding ...
Rastgar Jazii
doaj  

Epigenetic Changes in Tumor Suppressor Genes, P15, P16, APC-3 and E-cadherin in Body Fluid

Kaohsiung Journal of Medical Sciences, 2007
The inactivation of tumor suppressor genes by promoter methylation plays an important role in the development of cancers; it can also be used as a marker to distinguish cancerous cells from non-cancer cells.
Mei-Ling Chen, Julia Huei-Mei Chang, Kun-Tu Yeh, Ya-Sian Chang, Jan-Gowth Chang   +4 more
doaj   +1 more source

Multigene Panel Sequencing Reveals Cancer-Specific and Common Somatic Mutations in Colorectal Cancer Patients: An Egyptian Experience

Current Issues in Molecular Biology, 2022
This study aims at identifying common pathogenic somatic mutations at different stages of colorectal carcinogenesis in Egyptian patients. Our cohort included colonoscopic biopsies collected from 120 patients: 20 biopsies from patients with inflammatory ...
Amira Salah El-Din Youssef, Mohamed A. Abdel-Fattah, Mai M. Lotfy, Auhood Nassar, Mohamed Abouelhoda, Ahmed O. Touny, Zeinab K. Hassan, Mohammed Mohey Eldin, Abeer A. Bahnassy, Hussein Khaled, Abdel Rahman N. Zekri   +10 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comparison: a pilot study

BMC Cancer, 2010
Background We are developing a cross-species comparison strategy to distinguish between cancer driver- and passenger gene alteration candidates, by utilizing the difference in genomic location of orthologous genes between the human and other mammals.
Ji Xinglai, Tang Jie, Halberg Richard, Busam Dana, Ferriera Steve, Peña Maria, Venkataramu Chinnambally, Yeatman Timothy J, Zhao Shaying   +8 more
doaj   +1 more source

Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis. [PDF]

PLoS ONE, 2013
Constitutive activation of the Wnt pathway leads to adenoma formation, an obligatory step towards intestinal cancer. In view of the established role of Wnt in regulating stemness, we attempted the isolation of cancer stem cells (CSCs) from Apc- and Apc ...
Mehrnaz Ghazvini, Petra Sonneveld, Andreas Kremer, Patrick Franken, Andrea Sacchetti, Yaser Atlasi, Sabrina Roth, Rosalie Joosten, Ron Smits, Riccardo Fodde   +9 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mutational profile of KRAS-positive colorectal cancer

Сибирский онкологический журнал, 2022
Aim: to study the features of the molecular genetic profile of KRAS-positive colorectal cancer (CRC).Material and Methods. The study included 42 patients diagnosed with colorectal cancer.
E. N. Telysheva, E. G. Shaikhaev, G. P. Snigireva   +2 more
doaj   +1 more source

APC and MUTYH Analysis in FAP Patients: A Novel Mutation in APC Gene and Genotype-Phenotype Correlation [PDF]

Genes, 2018
APC and MUTYH genes are mutated in 70–90% and 10–30% of familial adenomatous polyposis cases (FAP) respectively. An association between mutation localization and FAP clinical phenotype is reported. The aims of this study were to determine APC and MUTYH mutational status in a small cohort of FAP patients and to evaluate the genotype-phenotype ...
D'Elia G., Caliendo G., Casamassimi A., Cioffi M., Molinari A. M., Vietri M. T.   +5 more
openaire   +2 more sources