Somatic Mutation Rate of the APC Gene [PDF]
Japanese Journal of Clinical Oncology, 2001 Somatic inactivation of the wild-type APC gene is involved in the development of adenoma of familial adenomatous polyposis. This situation is also true in sporadic adenomas. It is of biological interest to know the somatic mutation rate of the APC gene.The number of stem cells of the colon (N) and somatic mutation rate of the APC gene in a stem cell in
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PLoS ONE, 2021 The spectrum of somatic genetic variation in colorectal adenomas caused by biallelic pathogenic germline variants in the MSH3 gene, was comprehensively analysed to characterise mutational signatures and identify potential driver genes and pathways of ...
Claudia Perne +17 more
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Mesenchymal adenomatous polyposis coli plays critical and diverse roles in regulating lung development. [PDF]
, 2015 BackgroundAdenomatous polyposis coli (Apc) is a tumor suppressor that inhibits Wnt/Ctnnb1. Mutations of Apc will not only lead to familial adenomatous polyposis with associated epithelial lesions, but will also cause aggressive fibromatosis in ...
Bellusci, Saverio +9 more
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Meningiomas exhibit loss of heterozygosity of the APC gene [PDF]
Journal of Neuro-Oncology, 2007 The molecular mechanisms and candidate genes involved in development of meningiomas still need investigation and elucidation. In the present study 33 meningiomas were analyzed regarding genetic changes of tumor suppressor gene Adenomatous polyposis coli (APC), a component of the wnt signaling.
Pećina-Šlaus, Nives +5 more
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Genetic analysis in APC, KRAS, and TP53 in patients with stomach and colon cancer
Revista de Gastroenterología de México (English Edition), 2014 Background: Stomach cancer (SC) and colorectal cancer (CRC) present with high rates of incidence and mortality in the worldwide population. These 2 tumors are characterized by great genetic heterogeneity.
K.A. Palacio-Rúa +4 more
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Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine [PDF]
, 2016 Reactive oxygen species (ROS) participate in numerous cell responses, including proliferation, DNA damage, and cell death. Based on these disparate activities, both promotion and inhibition of ROS have been proposed for cancer therapy.
Blyth, Karen +6 more
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Análisis genético en APC, KRAS y TP53 en pacientes con cáncer de estómago y colon
Revista de Gastroenterología de México, 2014 Antecedentes: El cáncer de estómago (CE) y colorrectal (CCR) presentan altas tasas de incidencia y mortalidad en la población mundial. Estas 2 neoplasias se caracterizan por tener una gran heterogeneidad genética.
K.A. Palacio-Rúa +4 more
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Transcriptome analysis revealed unique genes as targets for the anti-inflammatory action of activated protein C in human macrophages. [PDF]
PLoS ONE, 2010 BACKGROUND: Activated protein C (APC) has been introduced as a therapeutic agent for treatment of patients with severe sepsis due to its unique anticoagulant and anti-inflammatory properties in the vascular system.
Claudia P Pereira +3 more
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Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]
, 2014 Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
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Expression of inflammation-related genes is associated with adipose tissue location in horses [PDF]
, 2013 Background : In humans, adipose tissue (AT) originating from different depots shows varying gene expression profiles. In horses, the risk of certain metabolic disorders may also be influenced by the impact of specific AT depots.
Bruynsteen, Lien +6 more
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