Results 51 to 60 of about 156,482 (265)

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

Measuring the differential expression of the major hypermethylated tumor suppressor genes in tissues of primary hepatocellular carcinoma

Journal of Genetic Engineering and Biotechnology
Background: Hepatocarcinogenesis is a multifactorial process that arises from a integration of genetic and epigenetic anomalies leading to abnormal gene expression and function. It is difficult to characterize HCC with a single biomarker. Our study aimed
Khalda Sayed Amr, Wafaa Mohamed Ezzat, Ahmed Ibrahim Saleh, Ahmed Heiba, Hend Amin, Refaat Refaat Kamel, Noha Eltaweel, Hoda Henery, Amr Omaia, Reham Ibrahim Siddik, Yasser Abdelghany Abdelazeem Elhosary   +10 more
doaj   +1 more source

Distinguishing Lung Adenocarcinoma from Lung Squamous Cell Carcinoma by Two Hypomethylated and Three Hypermethylated Genes: A Meta-Analysis. [PDF]

PLoS ONE, 2016
Significant differences in the aberrant methylation of genes exist among various histological types of non-small cell lung cancer (NSCLC), which includes adenocarcinoma (AC) and squamous cell carcinoma (SCC). Different chemotherapeutic regimens should be
Tao Huang, Jinyun Li, Cheng Zhang, Qingxiao Hong, Danjie Jiang, Meng Ye, Shiwei Duan   +6 more
doaj   +1 more source

APC as a checkpoint gene: The beginning or the end? [PDF]

Gastroenterology, 2002
Colorectal cancer (CRC) is one of the most common malignancies in the United States. In 2002, it is estimated that 148,300 new cases of CRC will be diagnosed, resulting in approximately 56,600 deaths.1 The latter renders CRC the second leading cause of deaths from cancer in the United States. An individual’s life-time risk of developing CRC is 6%, with
openaire   +1 more source

Somatic Mutations of the APC Gene in Primary Breast Cancers [PDF]

The American Journal of Pathology, 2000
APC gene mutations play an important role in the initiation step of colorectal carcinogenesis in both familial adenomatous polyposis (FAP) patients and non-FAP patients. Although the APC gene is expressed in most tissues, including the lung, liver, kidney, and mammary gland, its somatic mutations have rarely been found in primary tumors affecting these
K, Furuuchi, M, Tada, H, Yamada, A, Kataoka, N, Furuuchi, J, Hamada, M, Takahashi, S, Todo, T, Moriuchi   +8 more
openaire   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

Human Genomics, 2011
The development and progression of colorectal cancer (CRC) is a multi-step process, and the Wnt pathways with its two molecular gladiators adenomatous polyposis coli (APC) and β-catenin plays an important role in transforming a normal tissue into a ...
Sameer A, Shah Zaffar A, Abdullah Safiya, Chowdri Nissar A, Siddiqi Mushtaq A   +4 more
doaj   +1 more source

Sulfation‐Tunable Peptide‐Glycosaminoglycan Hydrogels for Hematopoietic Stem and Progenitor Cell Expansion

Advanced Functional Materials, EarlyView.
Co‐assembly of rationally designed glycosaminoglycan‐binding peptides with sulfated glycosaminoglycans yields supramolecular hydrogels with tunable mechanics and matrix‐mediated cytokine retention. The glycosaminoglycans thereby act as cofactors, driving a coil‐to‐β‐sheet transition that triggers gelation.
Shirel Veretnik, Prannoy Seth, Maximilian Fusenig, Jens Friedrichs, Nicole Fertala, Passant Atallah, Uwe Freudenberg, Ayala Lampel, Carsten Werner   +8 more
wiley   +1 more source

Role of magnifying endoscopy with narrow‐band imaging in the diagnosis of noninvasive gastric neoplasia

JGH Open, 2021
Background and Aim There are no globally approved, distinguishing criteria enabling the classification of gastric adenomas and intramucosal carcinomas for differential diagnosis of noninvasive neoplasia (NIN).
Keisuke Tanaka, Shinya Maekawa, Takashi Yoshida, Tatsuya Yamaguchi, Shinichi Takano, Shuya Matsuda, Hiroshi Hayakawa, Yasuaki Ishida, Masaru Muraoka, Satoshi Kawakami, Yoshimitsu Fukasawa, Toru Kuno, Fumihiko Iwamoto, Yuya Tsukui, Shoji Kobayashi, Yukiko Asakawa, Hiroko Shindo, Mitsuharu Fukasawa, Yasuhiro Nakayama, Taisuke Inoue, Tomoyoshi Uetake, Masahiko Ohtaka, Tadashi Sato, Kunio Mochizuki, Nobuyuki Enomoto   +24 more
doaj   +1 more source

Nanomaterial Strategies for Pulmonary Delivery of Immunotherapeutics in Lung Cancer Treatment

Advanced Healthcare Materials, EarlyView.
Inhalable immunotherapeutic nanomedicines enable organ‐selective immune modulation by overcoming pulmonary delivery barriers and concentrating therapy within lung tumors. This Review defines how nanomaterial properties govern airway deposition, retention, cellular partitioning, and immune activation across vaccines, checkpoint blockade, STING agonists,
Han Zhang, Wei Tang
wiley   +1 more source