Results 71 to 80 of about 155,361 (266)

Aberrant Methylation Profile and Microsatellit Instability in Turkish Sporadic Colorectal Carcinoma

Bezmiâlem Science, 2019
Objective:Genomic DNA obtained from paraffin blocks of the intended colorectal cancer cases was evaluated for promoting colorectal cancer by investigating the promoter methylation of 6 different gene promoter regions and microsatellite instability ...
Cumhur Gökhan EKMEKÇİ, Mine GÜLLÜOĞLU, Yersu KAPRAN, Ferhunde DİZDAROĞLU, Uğur ÖZBEK   +4 more
doaj   +1 more source

ANALYSIS OF TP53, APC, KRAS, AND MMR GENETIC MUTATIONS IN COLORECTAL CANCER: A REVIEW ARTICLE [PDF]

Sanamed
Introduction: Colorectal cancer (CRC) is one of the most common malignancies with significant global health and economic implications. Genetic mutations in genes such as TP53, APC, KRAS, and MMR play a crucial role in the development and progression of ...
Gavric Igor, Hodzic Edin, Sarajlic Lana, Salibasic Mirhan, Bajramagic Salem, Dizdarevic Advan, Kulovic Edin   +6 more
doaj   +1 more source

GPR124 Alleviates Blood–Brain Barrier Disruption by Enhancing Microvascular Endothelial Function after Traumatic Brain Injury

Advanced Science, EarlyView.
Our study reveals the protective role of GPR124 in maintaining BBB integrity and promoting neurological recovery following TBI. It makes a significant contribution by uncovering a novel molecular interaction between GPR124 and FGFBP1 and linking this to activation of the Wnt/β‐catenin signaling pathway in vascular repair mechanisms.
Chen Wang, Lin Cai, Qiuyuan Gong, Yang Yang, Yuqing Liang, Xinyu Niu, Lai Wei, Ze Liu, Shengju Wu, Yinghui Men, Yaohui Tang, Jun Ding, Hengli Tian, Hao Chen   +13 more
wiley   +1 more source

Genetic and Epigenetic Changes of Components Affecting the WNT Pathway in Colorectal Carcinomas Stratified by Microsatellite Instability

Neoplasia: An International Journal for Oncology Research, 2005
An unselected series of 310 colorectal carcinomas, stratified according to microsatellite instability (MSI) and DNA ploidy, was examined for mutations and/or promoter hypermethylation of five components of the WNT signaling cascade [APC, CTNNB1 (encoding
Lin Thorstensen, Guro E. Lind, Tone Løvig, Chieu B. Diep, Gunn I. Meling, Torleiv O. Rognum, Ragnhild A. Lothe   +6 more
doaj   +1 more source

APC and AXIN2 Are Promising Biomarker Candidates for the Early Detection of Adenomas and Hyperplastic Polyps

Cancer Informatics, 2020
Aberrant activation of the WNT/CTNNB1 pathway is notorious in colorectal cancer (CRC). Here, we demonstrate that the expression of specific and crucial WNT signaling pathway genes is linked to disease progression in colonic adenomatous (AP) and ...
Sama Rezasoltani, Mahrooyeh Hadizadeh, Mina Golmohammadi, Ehsan Nazemalhossini-Mojarad, Sina Salari, Hamid Rezvani, Hamid Asadzadeh-Aghdaei, Michael Ladomery, Chris Young, Fakhrosadat Anaraki, Sarah Almond, Maziar Ashrafian Bonab   +11 more
doaj   +1 more source

Alleles of the APC gene: An attenuated form of familial polyposis

Cell, 1993
An attenuated form of familial adenomatous polyposis coli, AAPC, causes relatively few colonic polyps, but still carries a significant risk of colon cancer. The mutant alleles responsible for this attenuated phenotype have been mapped in several families to the adenomatous polyposis coli (APC) locus on human chromosome 5q.
Lisa Spirio, Sylviane Olschwang, Joanna Groden, Margaret Robertson, Wade Samowitz, Geoff Joslyn, Lawrence Gelbert, Andrew Thliveris, Mary Carlson, Brith Otterud, Henry Lynch, Patrice Watson, Patrick Lynch, Pierre Laurent-Puig, Randall Burt, J.P. Hughes, Gilles Thomas, Mark Leppert, Ray White   +18 more
openaire   +2 more sources

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

High Humidity Exacerbates Psoriasiform Skin Disease Relapse by Increasing Tissue‐Resident Memory T Cells via Altering Skin Microbiota

Advanced Science, EarlyView.
We demonstrated that high humidity worsened psoriasis relapse in murine psoriasiform skin inflammation by increasing skin‐resident memory CD8+ cells via upregulating IL‐15Rα on keratinocytes. The increases in IL‐15Rα and memory CD8+ cells were attributed to S. nepalensis and its metabolite ADMA in skin exposed to high humidity.
Chun‐Ling Liang, Yuchao Chen, Chuanjian Lu, Huazhen Liu, Fenglian Qin, Sisi Dai, Feifei Qiu, Haiming Chen, Weihui Lu, Jonathan S. Bromberg, Zhenhua Dai   +10 more
wiley   +1 more source

Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate

Advanced Science, EarlyView.
In a lumbar spine instability model, dorsal root ganglion cells mediate the perception of relevant mechanical stresses through Piezo2 and subsequently release CGRP. CGRP activates the NF‐κB signaling pathway in cartilage endplate cells through the receptor RAMP1.
Hanpeng Xu, Wen Geng, Zhi Du, Yifan Du, Di Wu, Bide Tong, Huaizhen Liang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Kun Wang, Yu Song, Wenbin Hua, Yan Xu, Wencan Ke, Bingjin Wang, Cao Yang   +16 more
wiley   +1 more source

Metilación de genes supresores tumorales en cáncer colorrectal: relación con estadío clínico de la enfermedad

Revista Colombiana de Gastroenterología, 2019
El cáncer colorrectal es una enfermedad heterogénea, en cuya aparición se involucran factores hereditarios y ambientales. En las formas heredadas existen genes responsables de incrementar el desarrollo tumoral en los portadores, y se consideran a los ...
Alicia Elena Rojas de Atencio, Karelis Magdalena Urdaneta-Gutierrez, Jenny Carolina Zambrano Marcano, Raquel Alejandra Atencio Rojas, Maribel Quintero, Jenny Zadiz Cañizalez   +5 more
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