Results 61 to 70 of about 155,361 (266)

Germline Missense Changes in the APC Gene and Their Relationship to Disease [PDF]

Hereditary Cancer in Clinical Practice, 2004
La poliposis adenomatosa familiar (PAF) se caracteriza por la presencia de cientos a miles de adenomas que tapizan todo el colon y el recto. Las mutaciones sin sentido y con desplazamiento de marco en el gen de la poliposis adenomatosa coli (APC) representan la mayoría de las mutaciones identificadas hasta la fecha y predisponen principalmente al ...
Rodney J. Scott, R. Crooks, Lindy Joy Rose, John Attia, Ammarin Thakkinstian, L.H. Thomas, Allan D. Spigelman, Cliff Meldrum   +7 more
openaire   +3 more sources

Therapeutic Extracellular Vesicles from Synovial Fibroblast‐Primed MSCs for Osteoarthritis Treatment

Advanced Healthcare Materials, EarlyView.
EVs derived from the microenvironment of SFs transferred MSCs (miSF‐MSC‐EVs) enhanced the expression of miRNAs that regulate cell migration, cell adhesion, and the TGF‐β signaling pathway, demonstrating superior anti‐inflammatory and cartilage regeneration effects compared to conventional MSC‐EVs.
Seo Jeong Kim, Ji Seob Kim, Min Hee Moon, Jae‐Hyeok Jang, In Sun Hwang, Byung‐Hyun Cha   +5 more
wiley   +1 more source

Genomic evolution and complexity of the Anaphase-promoting Complex (APC) in land plants

BMC Plant Biology, 2010
Background The orderly progression through mitosis is regulated by the Anaphase-Promoting Complex (APC), a large multiprotein E3 ubiquitin ligase that targets key cell-cycle regulators for destruction by the 26 S proteasome.
Hemerly Adriana S, de Oliveira Antonio, Elofsson Arne, Vargas Lívia, Bretz Thiago, Rojas Cristian, Sagit Rauan, Pegoraro Camila, Eloy Núbia B, Lima Marcelo de F, Ferreira Paulo CG   +10 more
doaj   +1 more source

Role of magnifying endoscopy with narrow‐band imaging in the diagnosis of noninvasive gastric neoplasia

JGH Open, 2021
Background and Aim There are no globally approved, distinguishing criteria enabling the classification of gastric adenomas and intramucosal carcinomas for differential diagnosis of noninvasive neoplasia (NIN).
Keisuke Tanaka, Shinya Maekawa, Takashi Yoshida, Tatsuya Yamaguchi, Shinichi Takano, Shuya Matsuda, Hiroshi Hayakawa, Yasuaki Ishida, Masaru Muraoka, Satoshi Kawakami, Yoshimitsu Fukasawa, Toru Kuno, Fumihiko Iwamoto, Yuya Tsukui, Shoji Kobayashi, Yukiko Asakawa, Hiroko Shindo, Mitsuharu Fukasawa, Yasuhiro Nakayama, Taisuke Inoue, Tomoyoshi Uetake, Masahiko Ohtaka, Tadashi Sato, Kunio Mochizuki, Nobuyuki Enomoto   +24 more
doaj   +1 more source

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Genomic Instability of the APC Gene Found in Glioblastoma

Neurologia Croatica. Supplement, 2007
The etiology and pathogenesis of tumors of the central nervous system are still inadequately explained. This study analyses tumor suppressor gene— adenomatous polyposis coli (APC) in 28 patients with glioblastoma, the most aggressive form of glial tumors.
Pećina-Šlaus, Nives, Beroš, Vili, Nikuševa Martić, Tamara   +2 more
openaire   +3 more sources

MYH Gene Status in Polish FAP Patients without APC Gene Mutations [PDF]

Hereditary Cancer in Clinical Practice, 2006
Familial Adenomatous Polyposis (FAP) is an inheritable predisposition for the occurrence of numerous polyps in the large intestine. In about 50% of all patients, the occurrence of the disease is conditioned by heterozygotic mutations of the APC gene. Screening for genetic factors in persons without mutations in the APC gene led to the identification of
Skrzypczak Marzena, Podralska Marta, Heinritz Wolfram, Froster Ursula G, Lipiński Daniel, Słomski Ryszard, Pławski Andrzej   +6 more
openaire   +3 more sources

Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles

Advanced Materials, EarlyView.
This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen, Xiaoyu Wang, Jilin Fan, Bi Wang, Hanghang Fang, Yurui Wang, Hao Cui, Mohammad Roufarshbaf, Ekaterina Savina, Alexandra Valeske, Quim Peña, Yang Shi, Andreas Herrmann, Twan Lammers, Mathias Hornef, Roman Barmin, Thomas Lisson, Georg Schmitz, Anne Rix, Fabian Kiessling   +19 more
wiley   +1 more source

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source