Results 1 to 10 of about 513,937 (198)

Adenomatous Polyposis Coli (APC) in cell migration [PDF]

European Journal of Cell Biology, 2022
Adenomatous Polyposis Coli (APC) protein is mostly known as a tumor suppressor that regulates Wnt signaling, but is also an important cytoskeletal protein.
Xingyuan Fang, Tatyana M. Svitkina
doaj   +4 more sources

Adenomatous polyposis coli in cancer and therapeutic implications [PDF]

Oncology Reviews, 2021
Inactivating mutations of the adenomatous polyposis coli (APC) gene and consequential upregulation of the Wnt signaling pathway are critical initiators in the development of colorectal cancer (CRC), the third most common cancer in the United States for ...
Olivia Noe, Louis Filipiak, Rachel Royfman, Austin Campbell, Leslie Lin, Danae Hamouda, Laura Stanbery, John Nemunaitis   +7 more
doaj   +5 more sources

Rapidly Progressive Metastatic Sertoli Cell Tumor Associated With an Adenomatous Polyposis Coli Mutation: A Case Report and Literature Review. [PDF]

IJU Case Rep
ABSTRACT Introduction Sertoli cell tumors are rare testicular sex cord‐stromal tumors, and clinically malignant behavior is uncommon. We report a rapidly progressive metastatic Sertoli cell tumor associated with an APC mutation. Case Presentation A 27‐year‐old man with familial adenomatous polyposis (FAP) presented with painless right scrotal ...
Obayashi K, Terasaki M, Hasegawa H, Mikami H, Yanagi M, Takeda H, Endo Y, Toyama Y, Ohashi R, Akatsuka J.   +9 more
europepmc   +2 more sources

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization

Cell Reports, 2017
Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis and colorectal cancer development.
Vincenzo Di Bartolo, Jerome Bouchet, Rémi LASSERRE   +2 more
exaly   +3 more sources

Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion [PDF]

Journal of Cell Biology, 2020
Christopher J. Lengner, Tatyana M Svitkina, Kristi L Neufeld   +2 more
exaly   +2 more sources

AXIN2-Associated Adenomatous Colorectal Polyposis

Journal of Coloproctology, 2021
Introduction Most cases of colorectal cancer (CRC) occur sporadically; however, ∼ 3% to 6% of all CRCs are related to inherited syndromes, such as Lynch syndrome and familial adenomatous polyposis (FAP).
Bruno Augusto Alves Martins, Reinaldo Falluh Filho, Romulo Medeiros de Almeida, Renata Lazari Sandoval   +3 more
doaj   +1 more source

Mutation Spectrum of Familial Adenomatous Polyposis Patients in Turkish Population: Identification of 3 Novel APC Mutations

The Turkish Journal of Gastroenterology, 2022
Background: Familial adenomatous polyposis (OMIM #175100) and MUTYH-associated polyposis (OMIM #608456) are rare cancerprone disorders characterized by hundreds of adenomatous polyps in the colon and rectum, which have a high probability of malignant ...
Esra Arslan Ateş, Ceren Alavanda, Şenol Demir, Çağlayan Keklikkıran, Wafi Attaallah, Osman Cavit Özdoğan, Ahmet İlter Güney   +6 more
doaj   +1 more source

A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis

Cancer Biology & Medicine, 2021
Objective: In some patients with adenomatous polyposis, an identifiable pathogenic variant of known associated genes cannot be found. Researchers have studied this for decades; however, few new genes have been identified.
Mengyuan Yang, Yingxin Zhao, Yuwei Ding, Juan Wang, Yinuo Tan, Dong Xu, Ying Yuan   +6 more
doaj   +1 more source

A Two Generation of Familial Adenomatous Polyposis

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020
Familial adenomatous polyposis (FAP) is a part of genetic polyposis syndrome which is caused by germline mutation in the adenomatous polyposis coli (APC) gene located in chromosome 5q21. The pathognomonic features is formation of hundreds to thousands of
Lily Chandrawati, I Dewa Nyoman Wibawa
doaj   +1 more source

Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors

Nature Communications, 2022
The adenomatous polyposis coli (APC)–Asef protein interaction is essential for colorectal cancer metastasis. Here, the authors present the rational design of a sensitivity-enhanced tracer for fluorescence polarization assays, enabling them to discover ...
Jie Zhong, Yuegui Guo, Shaoyong Lu, Kun Song, Ying Wang, Li Feng, Zhen Zheng, Qiufen Zhang, Jiacheng Wei, Peng Sang, Yan Shi, Jianfeng Cai, Guoqiang Chen, Chen-Ying Liu, Xiuyan Yang, Jian Zhang   +15 more
doaj   +1 more source