Results 1 to 10 of about 20,014 (136)

Adenomatous Polyposis Coli (APC) in cell migration [PDF]

European Journal of Cell Biology, 2022
Adenomatous Polyposis Coli (APC) protein is mostly known as a tumor suppressor that regulates Wnt signaling, but is also an important cytoskeletal protein.
Xingyuan Fang, Tatyana M. Svitkina
doaj   +2 more sources

Adenomatous polyposis coli in cancer and therapeutic implications [PDF]

Oncology Reviews, 2021
Inactivating mutations of the adenomatous polyposis coli (APC) gene and consequential upregulation of the Wnt signaling pathway are critical initiators in the development of colorectal cancer (CRC), the third most common cancer in the United States for ...
Olivia Noe, Louis Filipiak, Rachel Royfman, Austin Campbell, Leslie Lin, Danae Hamouda, Laura Stanbery, John Nemunaitis   +7 more
doaj   +2 more sources

Adenomatous Polyposis Coli Defines Treg Differentiation and Anti-inflammatory Function through Microtubule-Mediated NFAT Localization

Cell Reports, 2017
Adenomatous polyposis coli (APC) is a polarity regulator and tumor suppressor associated with familial adenomatous polyposis and colorectal cancer development.
Vincenzo Di Bartolo, Jérôme Bouchet, Rémi Lasserre   +2 more
exaly   +3 more sources

Mutation Spectrum of Familial Adenomatous Polyposis Patients in Turkish Population: Identification of 3 Novel APC Mutations

The Turkish Journal of Gastroenterology, 2022
Background: Familial adenomatous polyposis (OMIM #175100) and MUTYH-associated polyposis (OMIM #608456) are rare cancerprone disorders characterized by hundreds of adenomatous polyps in the colon and rectum, which have a high probability of malignant ...
Esra Arslan Ateş, Ceren Alavanda, Şenol Demir, Çağlayan Keklikkıran, Wafi Attaallah, Osman Cavit Özdoğan, Ahmet İlter Güney   +6 more
doaj   +1 more source

A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis

Cancer Biology & Medicine, 2021
Objective: In some patients with adenomatous polyposis, an identifiable pathogenic variant of known associated genes cannot be found. Researchers have studied this for decades; however, few new genes have been identified.
Mengyuan Yang, Yingxin Zhao, Yuwei Ding, Juan Wang, Yinuo Tan, Dong Xu, Ying Yuan   +6 more
doaj   +1 more source

A Two Generation of Familial Adenomatous Polyposis

The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy, 2020
Familial adenomatous polyposis (FAP) is a part of genetic polyposis syndrome which is caused by germline mutation in the adenomatous polyposis coli (APC) gene located in chromosome 5q21. The pathognomonic features is formation of hundreds to thousands of
Lily Chandrawati, I Dewa Nyoman Wibawa
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Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors

Nature Communications, 2022
The adenomatous polyposis coli (APC)–Asef protein interaction is essential for colorectal cancer metastasis. Here, the authors present the rational design of a sensitivity-enhanced tracer for fluorescence polarization assays, enabling them to discover ...
Jie Zhong, Yuegui Guo, Shaoyong Lu, Kun Song, Ying Wang, Li Feng, Zhen Zheng, Qiufen Zhang, Jiacheng Wei, Peng Sang, Yan Shi, Jianfeng Cai, Guoqiang Chen, Chen-Ying Liu, Xiuyan Yang, Jian Zhang   +15 more
doaj   +1 more source

Gardner’s syndrome presenting as duodenal carcinoma in a young male [PDF]

Journal of Clinical and Scientific Research, 2015
Gardners syndrome (GS) is a variant of familial adenomatous polyposis (FAP) and presents with both colonic and extra colonic manifestations. It is an autosomal dominant disorder and results from mutations in adenomatous polyposis coli (APC) gene ...
Sarma YS, Bhaskararao G, Sriharibabu M, Nayak SR, Satyaprakash T   +4 more
doaj   +1 more source

Familial adenomatous polyposis coli

Journal of the Belgian Society of Radiology, 2011
Background: A 53-year-old male patient with a familial history of colon carcinoma presented with stool changes and abdominal cramps. There was no weight loss nor signs of blood in the stool.
K Boeren, Y Vankan, D Perdieus
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A Rare Case of Serrated Polyposis Syndrome with the MSH6 and SMARCA4 variants

European Journal of Case Reports in Internal Medicine, 2021
Serrated polyposis syndrome (SPS) is the most common form of polyposis syndrome and has been shown to increase the risk of colorectal cancer (CRC). The genetic pathway of CRC in SPS is different from the classic adenomatous polyposis coli (APC) pathway ...
Mahesh Nepal, Sravani Lokineni, Le Yu Naing, Jay Bapaye, Erik Olson   +4 more
doaj   +1 more source