Results 31 to 40 of about 22,051 (209)

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis. [PDF]

PLoS ONE, 2014
Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of the WNT pathway that is responsible for APC-associated diseases such as Familial Adenomatous Polyposis (FAP) and 85% of spontaneous colorectal cancers (
Bin Li, Colin A Flaveny, Camilla Giambelli, Dennis Liang Fei, Lu Han, Brian I Hang, Feng Bai, Xin-Hai Pei, Vania Nose, Oname Burlingame, Anthony J Capobianco, Darren Orton, Ethan Lee, David J Robbins   +13 more
doaj   +1 more source

Adenomatous polyposis coli gene as a gatekeeper.

Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru, 2002
The Adenomatous Polyposis Coli (APC) Gene is a tumor suppressor gene located in the chromosome 5q21. It has a sequence of 2843 amino acids and a weight of 312 kD. The mutation of the APC gene occurs at the early stages of most sporadic colorectal cancers; and up to 30% in familial adenomatous polyposis.
Nakayama, Takamori, Morishita, Tetsuo, Kamiya, Toshiaki   +2 more
openaire   +4 more sources

Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo [PDF]

, 2010
Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele
Newton, Ian P., Jarnicki, Andrew G., Nathke, Inke S.; id_orcid, Sansom, Owen, Nathke, I., Samuel, M., Suzuki, Hiromu, Tosh, David, Abud, H E, Newton, IP, Huelsken, J, Stacker, SA, Samuel, M S, Buchert, M, Ernst, M., Stacker, Steven, Stacker, S., Dimitris Athineos, Alan R Clarke, Newton Ian P., Helen E. Abud, Heath, JK, Abud Helen E., Clarke Alan R., Suzuki, H., Faux, Maree, Newton, I., Jarnicki, A.G., Meniel, VS, Michael Buchert, Ernst, Matthias, Sansom, Owen J., Sansom Owen J., Meniel, Valerie, Clarke, Alan R., Burke, Z D, Ian P Newton, Inke S Näthke, David Tosh, Näthke, I.S., Winbanks, Catherine, Ian P. Newton, Sansom, O J, Burke, Z., Samuel Michael S., Samuel, M.S., Näthke Inke S., Inke S. Näthke, Jarnicki, A G, Abud, H.E., Tosh, D, Burke, ZD, Catherine E Winbanks, Samuel, Michael S., Heath Joan K., Andrew G Jarnicki, Nusse, R., Jarnicki, Andrew, Meniel, V.S., Abud, H., Samuel, MS, Joan K Heath, Winbanks, C E, Clarke, A R, Winbanks, C.E., Suzuki Hiromu, Winbanks Catherine E., Clarke, Alan Richard, Clarke, A.R., Joerg Huelsken, Stacker, Steven A., Helen E Abud, Alan R. Clarke, Buchert, M., Owen J. Sansom, Abud, HE, Joan K. Heath, Faux Maree C., Jarnicki, AG, Owen J Sansom, Athineos Dimitris, Suzuki, H, Faux, M., Winbanks, C., Matthias Ernst, Huelsken Joerg, Athineos, D, Sansom, O.J., Burke, Zoe D., Meniel Valerie S., Huelsken, J., Tosh David, Newton, I.P., Samuel, Michael, Athineos, Dimitris, Ernst Matthias, Jarnicki Andrew G., Zoe D Burke, Stacker, S.A., Stacker, S A, Clarke, Alan, Buchert, Michael, Abud, Helen E., Michael S. Samuel, Jarnicki, A., Steven A Stacker, Meniel, Valerie S., Faux, M C, Athineos, D., Meniel, V., Ernst, M, Michael S Samuel, Heath, Joan K., Nathke, I S, Sansom, OJ, Newton, Ian, Tosh, D., Valerie S. Meniel, Clarke, AR, Newton, I P, Näthke, Inke S., Meniel, V S, Valerie S Meniel, Buchert Michael, Newton, Ian P, Heath, Joan, Maree C Faux, Näthke, IS, Burke, Z.D., Heath, J., Maree C. Faux, Faux, Maree C., Winbanks, Catherine E., Heath, J K, Faux, M.C., Abud, Helen, Catherine E. Winbanks, Faux, MC, Sansom, O., Burke, Zoe, Andrew G. Jarnicki, Steven A. Stacker, Hiromu Suzuki, Zoe D. Burke, Huelsken, Joerg, Heath, J.K., Stacker Steven A., Burke Zoe D., Winbanks, CE, Nathke, Inke, Clarke, A.   +150 more
core   +1 more source

CD36 – a plausible modifier of disease phenotype in familial adenomatous polyposis

Hereditary Cancer in Clinical Practice, 2018
Background Familial adenomatous polyposis (FAP) is a well characterised genetic predisposition to early onset colorectal cancer (CRC) that is characterised by polyposis of the colon and rectum.
Merran Holmes, Toni Connor, Christopher Oldmeadow, Peter G. Pockney, Rodney J. Scott, Bente A. Talseth-Palmer   +5 more
doaj   +1 more source

The link between colon cancer and congenital hypertrophy of the retinal pigment epithelium (CHRPE)

American Journal of Ophthalmology Case Reports, 2019
Purpose: Clarify the differences between Familial Adenomatous Polyposis (FAP)-associated Congenital Hypertrophy of the Retinal Epithelium (CHRPE) and benign variants with regards to lesion characteristics and associated risk.
Brent Deibert, Letisha Ferris, Noel Sanchez, Paul Weishaar   +3 more
doaj   +1 more source

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, Burkhard, Göke, B., Kolligs, Frank T, Bommer, Guido, Kolligs, F. T.   +5 more
core   +1 more source

Identification of novel germline mutations in hereditary colorectal cancer patients and characterization of somatic alterations in their tumors [PDF]

, 2008
Colorectal cancer has been reported as the third leading cause of cancer related death in the world. About 5-10% of colorectal cancers are due to an inherited predisposition.
Zhang, Jian
core   +1 more source

APC2 controls dendrite development by promoting microtubule dynamics

Nature Communications, 2018
Microtubules in dendrites are characterized by mixed polarity orientation. Here, the authors show a role for adenomatous polyposis coli 2 (APC2) in regulating dendrite microtubule dynamics and dendrite development.
Olga I. Kahn, Philipp Schätzle, Dieudonnée van de Willige, Roderick P. Tas, Feline W. Lindhout, Sybren Portegies, Lukas C. Kapitein, Casper C. Hoogenraad   +7 more
doaj   +1 more source

The Genomics of colorectal cancer: State of the art

, 2008
The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a stepwise progression from adenomatous polyp to carcinoma is well documented.
Hodgson, SV, Hodgson, Shirley V, Beggs, AD, Beggs, Andrew D; id_orcid   +3 more
core   +1 more source

Progression of duodenal neoplasia to advanced adenoma in patients with familial adenomatous polyposis

Hereditary Cancer in Clinical Practice, 2023
Background Patients with familial adenomatous polyposis (FAP) have a lifetime risk of developing duodenal adenomas approaching 100%, and the relative risk for duodenal cancer compared with the general population is high.
Hiroko Nakahira, Yoji Takeuchi, Yusaku Shimamoto, Shingo Ishiguro, Hiroshi Yunokizaki, Yasumasa Ezoe, Fumie Fujisawa, Ryu Ishihara, Tetsuji Takayama, Teruhiko Yoshida, Michihiro Mutoh, Hideki Ishikawa   +11 more
doaj   +1 more source