Results 31 to 40 of about 34,811 (221)
Familial adenomatous polyposis: a case report
Journal of Medical Case ReportsBackground Familial adenomatous polyposis is characterized by the presence of multiple colorectal adenomatous polyps and caused by germline mutations in the tumor suppressor gene and adenomatous polyposis coli, located on chromosome 5q21–q22.
Endeshaw Asaye Kindie +4 more
doaj +2 more sources
Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats [PDF]
, 2006 Recent epidemiological studies suggest that high meat intake is associated with promotion of colon cancer linked to haem-iron intake. We previously reported that dietary haem, in the form of either haemoglobin or meat, promotes precancerous lesions in ...
Guéraud, Françoise +5 more
core +1 more source
The link between colon cancer and congenital hypertrophy of the retinal pigment epithelium (CHRPE)
American Journal of Ophthalmology Case Reports, 2019 Purpose: Clarify the differences between Familial Adenomatous Polyposis (FAP)-associated Congenital Hypertrophy of the Retinal Epithelium (CHRPE) and benign variants with regards to lesion characteristics and associated risk.
Brent Deibert +3 more
doaj +1 more source
Progression of duodenal adenomatosis in familial adenomatous polyposis: due to ageing of subjects and advances in technology [PDF]
, 2011 Familial adenomatous polyposis patients are at risk of duodenal cancer. Surveillance is indicated and the extent of duodenal polyposis is quantified by the Spigelman staging system.
Elisabeth M. H. Mathus-Vliegen +3 more
core +2 more sources
Immunopurification of adenomatous polyposis coli (APC) proteins [PDF]
BMC Research Notes, 2013 AbstractBackgroundTheadenomatous polyposis coli(APC) tumour suppressor gene encodes a 2843 residue (310 kDa) protein. APC is a multifunctional protein involved in the regulation of β-catenin/Wnt signalling, cytoskeletal dynamics and cell adhesion.APCmutations occur in most colorectal cancers and typically result in truncation of the C-terminal half of ...
Elliott, KL +6 more
openaire +3 more sources
Cancer Biology:APC Delivers Kiss of Death to Focal Adhesions [PDF]
, 2017 New work shows that the actin-nucleating ability of the adenomatous polyposis coli protein is required for disassembly of focal adhesions. Loss of this function in Apc mutant cells reduces directed cell migration, potentially explaining the decreased ...
Näthke, Inke
core +2 more sources
Mouse models of colorectal cancer. [PDF]
, 2011 Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip +2 more
core +2 more sources
APC2 controls dendrite development by promoting microtubule dynamics
Nature Communications, 2018 Microtubules in dendrites are characterized by mixed polarity orientation. Here, the authors show a role for adenomatous polyposis coli 2 (APC2) in regulating dendrite microtubule dynamics and dendrite development.
Olga I. Kahn +7 more
doaj +1 more source
Hereditary Cancer in Clinical Practice, 2023 Background Patients with familial adenomatous polyposis (FAP) have a lifetime risk of developing duodenal adenomas approaching 100%, and the relative risk for duodenal cancer compared with the general population is high.
Hiroko Nakahira +11 more
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source