Results 11 to 20 of about 20,064 (176)

Hepatocellular Carcinoma in the Adolescent With Classical Familial Adenomatous Polyposis: Clinical Case

Вопросы современной педиатрии, 2020
Background. Hepatocellular carcinoma is rare disease in pediatrics, it affects mostly male adolescents aged 10–15 years. There are only 10 described cases of hepatocellular carcinoma and familial adenomatous polyposis combination.Clinical Case ...
Svetlana Ya. Volgina, Ralina R. Ganieva, Zilyara R. Garifullina, Rafik G. Saifutdinov, Eleonora R. Shamsiyeva, Diloram T. Abdullaeva   +5 more
doaj   +1 more source

AXIN2-Associated Adenomatous Colorectal Polyposis

Journal of Coloproctology, 2021
Introduction Most cases of colorectal cancer (CRC) occur sporadically; however, ∼ 3% to 6% of all CRCs are related to inherited syndromes, such as Lynch syndrome and familial adenomatous polyposis (FAP).
Bruno Augusto Alves Martins, Reinaldo Falluh Filho, Romulo Medeiros de Almeida, Renata Lazari Sandoval   +3 more
doaj   +1 more source

The role of PLK1 in cancer exhibiting chromosomal instability

Molecular & Cellular Oncology, 2018
Adenomatous polyposis coli (APC) mutations cause aneuploidy and are responsible for familial adenomatous polyposis characterized by chromosomal instability. PLK1 contributes to sustain an intact spindle assembly checkpoint ensuring genomic stability.
Klaus Strebhardt, Monika Raab, Mourad Sanhaji   +2 more
doaj   +1 more source

Giant adrenal cavernous hemangioma in a patient with familial adenomatous polyposis

Clinics and Practice, 2016
Adrenal hemangioma is an uncommon benign vascular tumor that is often discovered incidentally. It has never been reported in association with familial adenomatous polyposis.
Dhouha Bacha, Abir Chaabane, Fatma Khanchel, Saloua Néchi, Hassen Touinsi, Emna Chelbi   +5 more
doaj   +1 more source

Familial polyposis coli: the management of desmoid tumor bleeding

Open Medicine, 2019
There is currently no standard treatment for desmoid tumors (DTs) associated with familial polyposis coli (FAP). Familial adenomatous polyposis in DT patients is sometimes a life-threatening condition.
Calogero Armando, Sagnelli Caterina, Carlomagno Nicola, Tammaro Vincenzo, Candida Maria, Vernillo Antonio, Peluso Gaia, Minieri Gianluca, Sica Antonello, Ciccozzi Massimo, Santangelo Michele, Dodaro Concetta Anna   +11 more
doaj   +1 more source

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding

Nature Communications, 2021
The epitranscriptomic regulation of adenomatous polyposis coli (APC) tumour suppressor gene in cancers is unclear. Here the authors show that N6-methyladenosine methylation writer METTL3 downregulates APC by recruiting YTHDF2 for APC mRNA degradation ...
Wei Wang, Fei Shao, Xueying Yang, Juhong Wang, Rongxuan Zhu, Yannan Yang, Gaoxiang Zhao, Dong Guo, Yingli Sun, Jie Wang, Qi Xue, Shugeng Gao, Yibo Gao, Jie He, Zhimin Lu   +14 more
doaj   +1 more source

Adenomatous Polyposis Coli Gene Mutations in 22 Chinese Pedigrees with Familial Adenomatous Polyposis. [PDF]

Med Sci Monit, 2019
BACKGROUND Familial adenomatous polyposis (FAP), which has a very high tendency of progression to colorectal cancer, is mainly caused by mutations of the adenomatous polyposis coli (APC) gene. This study systematically screened the APC mutations and observed the correlation of APC mutations with clinical manifestations of FAP.
Wang D, Zhang Z, Li Y, Xu C, Yu Y, Li M, Chen C, Zhang X.   +7 more
europepmc   +4 more sources

APC (adenomatous polyposis coli) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on APC (adenomatous polyposis coli), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +3 more sources

Repurposing the FDA-approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis. [PDF]

PLoS ONE, 2014
Mutations in the WNT-pathway regulator ADENOMATOUS POLYPOSIS COLI (APC) promote aberrant activation of the WNT pathway that is responsible for APC-associated diseases such as Familial Adenomatous Polyposis (FAP) and 85% of spontaneous colorectal cancers (
Bin Li, Colin A Flaveny, Camilla Giambelli, Dennis Liang Fei, Lu Han, Brian I Hang, Feng Bai, Xin-Hai Pei, Vania Nose, Oname Burlingame, Anthony J Capobianco, Darren Orton, Ethan Lee, David J Robbins   +13 more
doaj   +1 more source

The adenomatous polyposis coli protein 30 years on

Seminars in Cell & Developmental Biology, 2023
Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space.
Abbott, James, Nathke, Inke S.
openaire   +3 more sources