Results 11 to 20 of about 34,811 (221)

Genotype-Phenotype Correlations in Attenuated Adenomatous Polyposis Coli [PDF]

The American Journal of Human Genetics, 1998
Germ-line mutations of the tumor suppressor APC are implicated in attenuated adenomatous polyposis coli (AAPC), a variant of familial adenomatous polyposis (FAP). AAPC is recognized by the occurrence of 40 years). The aim of this study was to assess genotype-phenotype correlations in AAPC families.
Soravia, Claudio, Berk, T, Madlensky, L, Mitri, A, Cheng, H, Gallinger, S, Cohen, Z, Bapat, B   +7 more
openaire   +5 more sources

Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors

Nature Communications, 2022
The adenomatous polyposis coli (APC)–Asef protein interaction is essential for colorectal cancer metastasis. Here, the authors present the rational design of a sensitivity-enhanced tracer for fluorescence polarization assays, enabling them to discover ...
Jie Zhong, Yuegui Guo, Shaoyong Lu, Kun Song, Ying Wang, Li Feng, Zhen Zheng, Qiufen Zhang, Jiacheng Wei, Peng Sang, Yan Shi, Jianfeng Cai, Guoqiang Chen, Chen-Ying Liu, Xiuyan Yang, Jian Zhang   +15 more
doaj   +1 more source

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation [PDF]

, 2013
A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT ...
A Gregorieff, A Horii, A Jung, A Novak, AC de Vries, AN Milne, AT Franco, B Kim, B Tycko, C Cavard, D Athineos, D M Pritchard, DM Parkin, E Half, E Tahara, EF Chan, G Gatta, H Guillen-Ahlers, H Ireland, H Luche, H Nagase, H Oshima, H Shibata, H Watanabe, H Zhang, HC Zheng, HJ Freeman, J Cordero, J Neumann, J Parsonnet, J Woodgett, JG Forte, K Miyazawa, K Oien, KF Becker, KW Kinzler, LK Bianchi, M Crabtree, M Iida, M Nakayama, M Shitashige, M Suzuki, M Suzuki, M Torbenson, MG Smith, MP Ebert, N Barker, N Barker, N Barker, N Barker, N Barker, N Harada, N Murata-Kamiya, N Uemura, O J Sansom, O Sokolova, O Tetsu, OJ Sansom, P Blache, P Correa, P Correa, P Lauren, P Salgueiro, P Soriano, PJ Guilford, R A Ridgway, R Kemp, R Poulsom, S Garrean, S Nakatsuru, S Patel, S Patel, S Radulescu, S Segditsas, S Sekine, SC Abraham, SC Abraham, SM Przemeck, SS Ng, T Gnad, T Oda, TC He, WM Clements, WS Park, XC He, Y Miyoshi, Y Park do, Z Spicer, Z Zhao   +88 more
core   +1 more source

Gardner’s syndrome presenting as duodenal carcinoma in a young male [PDF]

Journal of Clinical and Scientific Research, 2015
Gardners syndrome (GS) is a variant of familial adenomatous polyposis (FAP) and presents with both colonic and extra colonic manifestations. It is an autosomal dominant disorder and results from mutations in adenomatous polyposis coli (APC) gene ...
Sarma YS, Bhaskararao G, Sriharibabu M, Nayak SR, Satyaprakash T   +4 more
doaj   +1 more source

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, B., Kolligs, F. T.
core   +2 more sources

APC (adenomatous polyposis coli) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on APC (adenomatous polyposis coli), with data on DNA, on the protein encoded, and where the gene is implicated.
openaire   +3 more sources

A Rare Case of Serrated Polyposis Syndrome with the MSH6 and SMARCA4 variants

European Journal of Case Reports in Internal Medicine, 2021
Serrated polyposis syndrome (SPS) is the most common form of polyposis syndrome and has been shown to increase the risk of colorectal cancer (CRC). The genetic pathway of CRC in SPS is different from the classic adenomatous polyposis coli (APC) pathway ...
Mahesh Nepal, Sravani Lokineni, Le Yu Naing, Jay Bapaye, Erik Olson   +4 more
doaj   +1 more source

Hepatocellular Carcinoma in the Adolescent With Classical Familial Adenomatous Polyposis: Clinical Case

Вопросы современной педиатрии, 2020
Background. Hepatocellular carcinoma is rare disease in pediatrics, it affects mostly male adolescents aged 10–15 years. There are only 10 described cases of hepatocellular carcinoma and familial adenomatous polyposis combination.Clinical Case ...
Svetlana Ya. Volgina, Ralina R. Ganieva, Zilyara R. Garifullina, Rafik G. Saifutdinov, Eleonora R. Shamsiyeva, Diloram T. Abdullaeva   +5 more
doaj   +1 more source

Examination of actin and microtubule dependent APC localisations in living mammalian cells [PDF]

, 2006
(provisional) Background The trafficking of the adenomatous polyposis coli (APC) tumour suppressor protein in mammalian cells is a perennially controversial topic. Immunostaining evidence for an actin-associated APC localisation at intercellular
Adams, A., Askham, J.M., Langford, K.J., Lee, T., Morrison, E.E.   +4 more
core   +3 more sources

Wnt signalling in intestinal stem cells: lessons from mice and flies [PDF]

, 2018
Adult stem cells play critical roles in the basal maintenance of tissue integrity, also known as homeostasis, and in tissue regeneration following damage. The highly conserved Wnt signalling pathway is a key regulator of stem cell fate.
Carroll, Lynsey, Cordero, Julia, Perochon, Jessica   +2 more
core   +2 more sources