Germline Missense Changes in the APC Gene and Their Relationship to Disease [PDF]
Hereditary Cancer in Clinical Practice, 2004 Familial adenomatous polyposis (FAP) is characterized by the presence of hundreds to thousands of adenomas that carpet the entire colon and rectum. Nonsense and frameshift mutations in the adenomatous polyposis coli (APC) gene account for the majority of
Scott Rodney J +7 more
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APC gene promoter methylation as a potential biomarker for lung cancer diagnosis: A meta‐analysis [PDF]
Thoracic Cancer, 2021 Background The aim of this study was to quantitatively analysis the diagnostic performance of adenomatous polyposis coli (APC) gene promoter methylation in serum or sputum/bronchoalveolar lavage fluid (BLAF) as a biomarker for lung cancer identification ...
Fang Liu +3 more
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Deciphering the Causative Role of a Novel APC Gene Variant in Attenuated Familial Adenomatous Polyposis Using Germline DNA-RNA Paired Testing [PDF]
BiomedicinesBackground/Objectives: Familial adenomatous polyposis (FAP) is an autosomal dominant disorder caused by pathogenic variants in the adenomatous polyposis coli (APC) gene.
Giovanna Forte +11 more
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Peripheral nerve sheath tumors in the head and neck in patients with APC gene deletion mutations: a case report and scoping review of the literature [PDF]
Clinical and Experimental PediatricsAdenomatous polyposis coli (APC) is a tumor suppressor gene expressed throughout the body. APC mutations increase the risk of malignancy and are often characterized by syndromes that encompass a spectrum of neoplastic manifestations, such as familial ...
Koral M. Blunt +3 more
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Novel APC gene mutations associated with protein alteration in diffuse type gastric cancer [PDF]
BMC Medical Genetics, 2017 Background The role of adenomatous polyposis coli (APC) gene in mitosis might be critical for regulation of genomic stability and chromosome segregation.
Souvik Ghatak +5 more
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Molecular Analysis of Biliary Tract Neoplasms Associated with Familial Adenomatous Polyposis [PDF]
Journal of the Anus, Rectum and ColonObjectives: Familial adenomatous polyposis (FAP) is an inherited disorder characterized by multiple colorectal polyposis and is frequently associated with a variety of extracolonic lesions.
Takehiro Shiraishi +11 more
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A neoepitope derived from a novel human germline APC gene mutation in familial adenomatous polyposis shows selective immunogenicity. [PDF]
PLoS ONE, 2018 Familial adenomatous polyposis (FAP) is an inherited condition arising from genetic defects in the Adenomatous polyposis coli (APC) gene. Carriers with mutations in the APC gene develop polyps in the colon and rectum which if not managed, transition into
Snigdha Majumder +16 more
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A pan-cancer analysis on the carcinogenic effect of human adenomatous polyposis coli.
PLoS ONE, 2022 Adenomatous polyposis coli (APC) is the most commonly mutated gene in colon cancer and can cause familial adenomatous polyposis (FAP). Hypermethylation of the APC promoter can also promote the development of breast cancer, indicating that APC is not ...
Yinci Zhang +3 more
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Вопросы современной педиатрии, 2020 Background. Hepatocellular carcinoma is rare disease in pediatrics, it affects mostly male adolescents aged 10–15 years. There are only 10 described cases of hepatocellular carcinoma and familial adenomatous polyposis combination.Clinical Case ...
Svetlana Ya. Volgina +5 more
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APC Promoter Methylation in Gastrointestinal Cancer
Frontiers in Oncology, 2021 The adenomatous polyposis coli (APC) gene, known as tumor suppressor gene, has the two promoters 1A and 1B. Researches on APC have usually focused on its loss-of-function variants causing familial adenomatous polyposis.
Lila Zhu +6 more
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