Novel APC gene mutations associated with protein alteration in diffuse type gastric cancer [PDF]
BMC Medical Genetics, 2017 Background The role of adenomatous polyposis coli (APC) gene in mitosis might be critical for regulation of genomic stability and chromosome segregation.
Souvik Ghatak +5 more
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Gut microbiome associated with APC gene mutation in patients with intestinal adenomatous polyps. [PDF]
Int J Biol Sci, 2020 Background: The 'adenoma-carcinoma sequence' is a well-recognized model of colorectal cancer (CRC) development. However, the interaction between gut microbiota and genetic variation in the initiation of CRC is not clear. Our study attempts to demonstrate
Liang S +10 more
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Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene. [PDF]
Human Molecular Genetics, 1992 We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients. In addition to loss of heterozygosity (LOH) at the APC locus in 30 tumors, 43 other somatic mutations were detected.
Y. Mori +9 more
semanticscholar +3 more sources
Correlation between the methylation of APC gene promoter and colon cancer. [PDF]
Oncol Lett, 2017 The present study was planned to explore the correlation between the methylation of APC (adenomatous polyposis coli) and colon carcinogenesis. Colon cancer tissues and tumor-adjacent normal tissues of 60 colon cancer patients (who received surgical ...
Li BQ, Liu PP, Zhang CH.
europepmc +2 more sources
A novel mutation of adenomatous polyposis coli (APC) gene results in the formation of supernumerary teeth. [PDF]
J Cell Mol Med, 2018 Supernumerary teeth are teeth that are present in addition to normal teeth. Although several hypotheses and some molecular signalling pathways explain the formation of supernumerary teeth, but their exact disease pathogenesis is unknown.
Yu F +5 more
europepmc +2 more sources
APC gene promoter methylation as a potential biomarker for lung cancer diagnosis: A meta‐analysis [PDF]
Thoracic Cancer, 2021 Background The aim of this study was to quantitatively analysis the diagnostic performance of adenomatous polyposis coli (APC) gene promoter methylation in serum or sputum/bronchoalveolar lavage fluid (BLAF) as a biomarker for lung cancer identification ...
Fang Liu +3 more
doaj +2 more sources
PLoS ONE, 2011 Hypermethylation of the promoter of the tumor suppressor gene, adenomatous polyposis coli (APC), occurs in various malignancies, including hepatocellular carcinoma (HCC). However, reports on the specificity of the methylation of the APC gene for HCC have
Surbhi Jain +13 more
doaj +2 more sources
Deciphering the Causative Role of a Novel APC Gene Variant in Attenuated Familial Adenomatous Polyposis Using Germline DNA-RNA Paired Testing [PDF]
BiomedicinesBackground/Objectives: Familial adenomatous polyposis (FAP) is an autosomal dominant disorder caused by pathogenic variants in the adenomatous polyposis coli (APC) gene.
Giovanna Forte +11 more
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Peripheral nerve sheath tumors in the head and neck in patients with APC gene deletion mutations: a case report and scoping review of the literature [PDF]
Clinical and Experimental PediatricsAdenomatous polyposis coli (APC) is a tumor suppressor gene expressed throughout the body. APC mutations increase the risk of malignancy and are often characterized by syndromes that encompass a spectrum of neoplastic manifestations, such as familial ...
Koral M. Blunt +3 more
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