Results 11 to 20 of about 194,615 (302)

Meningiomas exhibit loss of heterozygosity of the APC gene [PDF]

Journal of Neuro-Oncology, 2007
The molecular mechanisms and candidate genes involved in development of meningiomas still need investigation and elucidation. In the present study 33 meningiomas were analyzed regarding genetic changes of tumor suppressor gene Adenomatous polyposis coli (APC), a component of the wnt signaling.
Pećina-Šlaus, Nives, Nikuševa Martić, Tamara, Tomas, Davor, Beroš, Vili, Zeljko, Martina, Čupić, Hrvoje   +5 more
openaire   +10 more sources

A Case of Sporadic Multiple Colonic Polyps in a Young Woman

Current Oncology, 2023
Sporadic colorectal cancer arises from an adenoma. As mutations in the adenomatous polyposis coli (APC) tumor suppressor gene have been frequently detected in colorectal adenomas, the APC gene is considered a gatekeeper in colorectal carcinogenesis. Here,
Seung Ho Sin, Jung Hwan Yoon, Sang Woo Kim, Won Sang Park, Hiun Suk Chae   +4 more
doaj   +1 more source

Methylation of the CpG sites only on the sense strand of the APC gene is specific for hepatocellular carcinoma. [PDF]

PLoS ONE, 2011
Hypermethylation of the promoter of the tumor suppressor gene, adenomatous polyposis coli (APC), occurs in various malignancies, including hepatocellular carcinoma (HCC). However, reports on the specificity of the methylation of the APC gene for HCC have
Surbhi Jain, Ting-Tsung Chang, James P Hamilton, Selena Y Lin, Yih-Jyh Lin, Alison A Evans, Florin M Selaru, Pin-Wen Lin, Shun-Hua Chen, Timothy M Block, Chi-Tan Hu, Wei Song, Stephen J Meltzer, Ying-Hsiu Su   +13 more
doaj   +1 more source

Readthrough of premature termination codons in the adenomatous polyposis coli gene restores its biological activity in human cancer cells. [PDF]

PLoS ONE, 2011
The APC tumor suppressor gene is frequently mutated in human colorectal cancer, with nonsense mutations accounting for 30% of all mutations in this gene.
Célia Floquet, Jean-Pierre Rousset, Laure Bidou   +2 more
doaj   +1 more source

APC mutation correlated with poor response of immunotherapy in colon cancer

BMC Gastroenterology, 2023
Objective APC (adenomatous polyposis coli) gene mutation is a central initialization in colon cancer tumorigenesis. However, the connection between APC gene mutation and immunotherapy efficacy for colon cancer remains unknown. This study aimed to explore
Bing Li, Guoliang Zhang, Xuejie Xu
doaj   +1 more source

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene [PDF]

Human Molecular Genetics, 1992
We examined somatic mutations of the adenomatous polyposis coli (APC) gene in 63 colorectal tumors (16 adenomas and 47 carcinomas) developed in familial adenomatous polyposis (FAP) and non-FAP patients. In addition to loss of heterozygosity (LOH) at the APC locus in 30 tumors, 43 other somatic mutations were detected.
Y, Miyoshi, H, Nagase, H, Ando, A, Horii, S, Ichii, S, Nakatsuru, T, Aoki, Y, Miki, T, Mori, Y, Nakamura   +9 more
openaire   +2 more sources

p53 and APC gene mutations: software and databases [PDF]

Nucleic Acids Research, 1997
A large number of different mutations in the APC and p53 tumor suppressor genes have been identified in various types of cancer. This substantial increase since our previous reports can enable analyses which were not previously possible. In order to capture all these new data, the software permitting analysis has been improved.
Christophe Béroud, Thierry Soussi
openaire   +2 more sources

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis [PDF]

, 2007
Mutations in the adenomatous polyposis coli (APC) tumor suppressor gene initiate a majority of colorectal cancers. Acquisition of chromosomal instability is an early event in these tumors.
Newton, Ian P., Clarke, Alan Richard, Jamieson, TJ, Sansom, Owen, Nathke, Inke S.; id_orcid, Alan Clarke, Newton, IP, Clarke, A, Ian P. Newton, Owen Sansom, Thomas J. Jamieson, Dikovskaya, D, Meniel, V, Kroboth, K, Sansom, O, Dikovskaya, Dina, Oakley, A, Oakley, Abigail, Abigail Oakley, Nathke, IS, Schiffmann, D, Valerie Meniel, Clarke, Alan, Schiffmann, David, Kroboth, Karin, David Schiffmann, Nathke, Inke S., Sansom, Owen J., Dina Dikovskaya, Inke S. Näthke, Karin Kroboth, Meniel, Valerie, Jamieson, Thomas J.   +32 more
core   +1 more source

Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (The Netherlands). [PDF]

, 2005
OBJECTIVE: The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer.
Roemen, Guido M J M, Brandt, P.A. van den, Goldbohm, R.A., Goldbohm, R Alexandra, Lentjes, Marjolein H F M, Lentjes, Marjolein HFM, van den Brandt, Piet A, Wark, Petra A.; id_orcid, Goldbohm, R. Alexandra, Van Den Brandt, Piet A., Veer, P. van 't, van 't Veer, Pieter, Bruine, A.P., de, Weijenberg, Matty P., Weijenberg, Matty P, Roemen, G.M.J.M., de Bruïne, Adriaan P, de Goeij, Anton FPM, Wark, P.A., De Goeij, Anton F P M, Veer, P., van 't, Bruïne, A.P. de, Brink, M., van 't Veer, P., van den Brandt, P.A., Luchtenborg, M., Goeij, A.F.P.M. de, De Bruïne, Adriaan P., de Bruine, A.P., Weijenberg, M.P., Wark, Petra A, Lüchtenborg, Margreet, Roemen, Guido MJM, Brink, Mirian, de Goeij, A.F., Goeij, A.F.P.M., de, Lentjes, M.H.F.M., de Goeij, A.F.P.M., Van't Veer, Pieter, Brandt, P.A., van den   +39 more
core   +1 more source

Gene expression analyses on skin lesions from patients with familial adenomatous polyposis [PDF]

, 2014
Familial adenomatous polyposis coli (FAP) is an autosomal dominant colorectal cancer predisposition syndrome caused by germline mutations in the APC gene.
Stegmann, Danielle Alexandra
core   +1 more source