Results 1 to 10 of about 30,293 (217)

The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin. [PDF]

PLoS ONE, 2012
The tumour suppressor Adenomatous Polyposis Coli (APC) is required for proper mitosis; however, the exact role of APC in mitosis is not understood. Using demembranated sperm chromatin exposed to meiotic Xenopus egg extract and HeLa cells expressing ...
Dina Dikovskaya, Guennadi Khoudoli, Ian P Newton, Gaganmeet S Chadha, Daniel Klotz, Ashwat Visvanathan, Angus Lamond, Jason R Swedlow, Inke S Näthke   +8 more
doaj   +6 more sources

Characterization of Adenomatous Polyposis Coli Protein Dynamics and Localization at the Centrosome. [PDF]

Cancers (Basel), 2016
The adenomatous polyposis coli (APC) tumor suppressor is a multifunctional regulator of Wnt signaling and acts as a mobile scaffold at different cellular sites. APC was recently found to stimulate microtubule (MT) growth at the interphase centrosome; however, little is known about its dynamics and localization at this site. To address this, we analysed
Lui C, Mok MT, Henderson BR.
europepmc   +4 more sources

The adenomatous polyposis coli protein 30 years on

Seminars in Cell and Developmental Biology, 2023
Mutations in the gene encoding the Adenomatous polyposis coli protein (APC) were discovered as driver mutations in colorectal cancers almost 30 years ago. Since then, the importance of APC in normal tissue homeostasis has been confirmed in a plethora of other (model) organisms spanning a large evolutionary space.
James C Abbott, Inke S Näthke
exaly   +4 more sources

Adenomatous polyposis coli protein deletion leads to cognitive and autism-like disabilities. [PDF]

Mol Psychiatry, 2014
Intellectual disabilities (IDs) and autism spectrum disorders link to human APC inactivating gene mutations. However, little is known about adenomatous polyposis coli's (APC's) role in the mammalian brain. This study is the first direct test of the impact of APC loss on central synapses, cognition and behavior. Using our newly generated APC conditional
Mohn JL, Alexander J, Pirone A, Palka CD, Lee SY, Mebane L, Haydon PG, Jacob MH.   +7 more
europepmc   +4 more sources

Deciphering the Causative Role of a Novel APC Gene Variant in Attenuated Familial Adenomatous Polyposis Using Germline DNA-RNA Paired Testing [PDF]

Biomedicines
Background/Objectives: Familial adenomatous polyposis (FAP) is an autosomal dominant disorder caused by pathogenic variants in the adenomatous polyposis coli (APC) gene.
Giovanna Forte, Candida Fasano, Matteo Iacoviello, Valentina Grossi, Martina Lepore Signorile, Katia De Marco, Paola Sanese, Antonia Lucia Buonadonna, Andrea Manghisi, Nicoletta Maria Tutino, Vittoria Disciglio, Cristiano Simone   +11 more
doaj   +2 more sources

Neuronal localization of the adenomatous polyposis coli tumor suppressor protein

Neuroscience, 1999
Recent biochemical studies have demonstrated that the adenomatous polyposis coli gene, initially identified via its link to colon cancer, is expressed at high levels in the brain. Furthermore, the ability of this tumor suppressor protein to bind to Discs-Large and beta-catenin, proteins implicated in organizing synaptic structure, point to a role for ...
J S, Brakeman, S H, Gu, X B, Wang, G, Dolin, J M, Baraban   +4 more
exaly   +3 more sources

Adenomatous polyposis coli-binding protein end-binding 1 promotes hepatocellular carcinoma growth and metastasis.

PLoS ONE, 2020
This study was performed to determine the clinical significance of adenomatous polyposis coli (APC)-binding protein end-binding 1 (EB1) in hepatocellular carcinoma (HCC) and to characterize its biochemical role in comparison with previous reports.
Takeshi Aiyama, Tatsuya Orimo, Hideki Yokoo, Takanori Ohata, Kanako C Hatanaka, Yutaka Hatanaka, Moto Fukai, Toshiya Kamiyama, Akinobu Taketomi   +8 more
doaj   +5 more sources

Molecular basis for the recognition of adenomatous polyposis coli by the Discs Large 1 protein. [PDF]

PLoS ONE, 2011
The human Discs Large 1 (DLG1) protein uses two of its three PDZ domains to interact with the C-terminal peptide of the Adenomatous Polyposis Coli (APC) tumor suppressor protein.
Zhenyi Zhang, Hua Li, Leyi Chen, Xingyu Lu, Jian Zhang, Ping Xu, Kui Lin, Geng Wu   +7 more
doaj   +4 more sources

A truncated protein product of the germline variant of the DUOX2 gene leads to adenomatous polyposis

Cancer Biology & Medicine, 2021
Objective: In some patients with adenomatous polyposis, an identifiable pathogenic variant of known associated genes cannot be found. Researchers have studied this for decades; however, few new genes have been identified.
Mengyuan Yang, Yingxin Zhao, Yuwei Ding, Juan Wang, Yinuo Tan, Dong Xu, Ying Yuan   +6 more
doaj   +1 more source

AXIN2-Associated Adenomatous Colorectal Polyposis

Journal of Coloproctology, 2021
Introduction Most cases of colorectal cancer (CRC) occur sporadically; however, ∼ 3% to 6% of all CRCs are related to inherited syndromes, such as Lynch syndrome and familial adenomatous polyposis (FAP).
Bruno Augusto Alves Martins, Reinaldo Falluh Filho, Romulo Medeiros de Almeida, Renata Lazari Sandoval   +3 more
doaj   +1 more source