Results 1 to 10 of about 17,976 (173)
eLife, 2023 ZRANB1 (human Trabid) missense mutations have been identified in children diagnosed with a range of congenital disorders including reduced brain size, but how Trabid regulates neurodevelopment is not understood.
Daniel Frank +15 more
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The adenomatous polyposis coli protein. [PDF]
Molecular Pathology, 1999 Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell.
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Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance [PDF]
Journal of Cell Science, 2013 Since its discovery as the major tumour suppressor in colorectal cancer, the adenomatous polyposis coli (APC) protein has emerged as a multi-functional protein that directly or indirectly regulates the cellular processes that govern epithelial tissues ([McCartney and Nathke, 2008][1]).
Nelson, Scott, Näthke, Inke S.
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A pan-cancer analysis on the carcinogenic effect of human adenomatous polyposis coli.
PLoS ONE, 2022 Adenomatous polyposis coli (APC) is the most commonly mutated gene in colon cancer and can cause familial adenomatous polyposis (FAP). Hypermethylation of the APC promoter can also promote the development of breast cancer, indicating that APC is not ...
Yinci Zhang +3 more
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Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy
Frontiers in Molecular Biosciences, 2021 In Colorectal cancer (CRC), adenomatous polyposis coli (APC) directly interacts with the Rho guanine nucleotide exchange factor 4 (Asef) and releases its GEF activity.
Xiuyan Yang +7 more
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iScience, 2023 Summary: Activation of Wnt signaling triggers macropinocytosis and drives many tumors. We now report that the exogenous addition of the second messenger lipid sn-1,2 DAG to the culture medium rapidly induces macropinocytosis.
Yagmur Azbazdar +6 more
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The Threshold Level of Adenomatous Polyposis Coli Protein for Mouse Intestinal Tumorigenesis [PDF]
Cancer Research, 2005 Abstract The adenomatous polyposis coli (APC) gene, whose mutations are responsible for familial adenomatous polyposis, is a major negative controller of the Wnt/β-catenin pathway. To investigate the dose-dependent effects of APC protein in suppressing intestinal tumorigenesis, we constructed mutant mice carrying hypomorphic Apc alleles ...
Qin, Li +3 more
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Neurite outgrowth involves adenomatous polyposis coli protein and β-catenin [PDF]
Journal of Cell Science, 2005 Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites. The mechanisms underlying neurite formation are poorly understood. A candidate protein for controlling neurite extension is the adenomatous polyposis coli (APC) protein, which regulates membrane extensions, microtubules and β-
Violet, Votin +2 more
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The International Journal of Biological Markers, 2013 Familial adenomatous polyposis (FAP) is an autosomal dominant disorder related to germline mutations of the adenomatous polyposis coli ( APC ) gene. It is characterized by the detection of numerous adenomatous polyps that, if untreated, develop into ...
Laura Schirosi +5 more
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Rapamycin inhibition of polyposis and progression to dysplasia in a mouse model.
PLoS ONE, 2014 Familial adenomatous polyposis (FAP) is often due to adenomatous polyposis coli (APC) gene germline mutations. Somatic APC defects are found in about 80% of colorectal cancers (CRCs) and adenomas.
Karin M Hardiman +4 more
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