Results 41 to 50 of about 30,293 (217)
Neoplasia: An International Journal for Oncology Research, 2013 Desmoid tumor (also called aggressive fibromatosis) is a lesion of mesenchymal origin that can occur as a sporadic tumor or a manifestation of the preneoplastic syndrome, familial adenomatous polyposis caused by a mutation in adenomatous polyposis coli ...
Ronak Ghanbari-Azarnier +4 more
doaj +1 more source
Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer [PDF]
Organoid, 2023 Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology.
Yonghyo Kim +3 more
doaj +1 more source
Molecular Oncology, 2022 Ribosomal biogenesis and protein synthesis are deregulated in most cancers, suggesting that interfering with translation machinery may hold significant therapeutic potential. Here, we show that loss of the tumor suppressor adenomatous polyposis coli (APC)
Christoph Otto +15 more
doaj +1 more source
Gene Expression Profiling in Familial Adenomatous Polyposis Adenomas and Desmoid Disease [PDF]
, 2007 Gene expression profiling is a powerful method by which alterations in gene expression can be interrogated in a single experiment. The disease familial adenomatous polyposis (FAP) is associated with germline mutations in the APC gene, which result in ...
Nikola A Bowden +2 more
core +1 more source
Adenomatous Polyposis Coli as a Scaffold for Microtubule End-Binding Proteins
Journal of Molecular Biology, 2019 End-binding proteins (EBs), referred to as the core components of the microtubule plus-end tracking protein network, interact with the C-terminus of the adenomatous polyposis coli (APC) tumor suppressor. This interaction is disrupted in colon cancers expressing truncated APC.
Serre, Laurence +2 more
openaire +5 more sources
Cell Reports, 2021 Summary: Colorectal cancer (CRC) is one of the most common cancers worldwide, in which adenomatous polyposis coli (APC) mutations are frequently and uniquely observed.
Zhenzhen Chen +8 more
doaj +1 more source
Contribution of MUTYH variants to male breast cancer risk: results from a multicenter study in Italy [PDF]
, 2018 Inherited mutations in BRCA1, and, mainly, BRCA2 genes are associated with increased risk of male breast cancer (MBC). Mutations in PALB2 and CHEK2 genes may also increase MBC risk.
Azzollini, Jacopo +25 more
core +3 more sources
APCI1307K Mutations and Forkhead Box Gene (FOXO1A): Another Piece of an Interesting Correlation
The International Journal of Biological Markers, 2012 Purpose Germline nonsense and frameshift mutations in the adenomatous polyposis coli (APC) gene are found in approximately 90% of individuals affected by familial adenomatous polyposis (FAP) and a genotype-phenotype relationship has been observed ...
Marco Agostini +16 more
doaj +1 more source
APC-driven actin nucleation powers collective cell dynamics in colorectal cancer cells
iScience, 2023 Summary: Cell remodeling relies on dynamic rearrangements of cell contacts powered by the actin cytoskeleton. The tumor suppressor adenomatous polyposis coli (APC) nucleate actin filaments (F-actin) and localizes at cell junctions.
Lautaro Baro +4 more
doaj +1 more source
Cancer genetics: Tumor suppressor meets oncogene [PDF]
, 1999 The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the
Adami, Fabian +9 more
core +60 more sources