Results 61 to 70 of about 30,293 (217)

Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein [PDF]

Proceedings of the National Academy of Sciences, 2002
Mutations in the adenomatous polyposis coli ( APC ) gene are responsible for familial adenomatous polyposis coli and also sporadic colorectal cancer development. By using antibodies raised against the N-terminal region of APC protein, we have detected the variable masses of endogenous APC proteins in individual cell
Miwako Kato, Homma, Dongxia, Li, Edwin G, Krebs, Yasuhito, Yuasa, Yoshimi, Homma   +4 more
openaire   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs

Cell Insight
Tumor suppressor protein Adenomatous polyposis coli protein (APC) is an EB-binding and microtubule (MT) plus end-tracking protein; however, how exactly APC regulates MT dynamics remains elusive.
Yong Wang, Xinping Liu, Zheng Liu, Shasha Hua, Kai Jiang   +4 more
doaj   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium [PDF]

, 2016
Aberrant Wnt signaling within breast cancer is associated with poor prognosis, but regulation of this pathway in breast tissue remains poorly understood and the consequences of immediate or long-term dysregulation remain elusive.
A Grigoriadis, A Imbert, A R Clarke, A Tanaka, AC Lesko, AI Khramtsov, AK Rajasekaran, AM Hassanein, AM Thompson, AR Moser, B Mann, BM Gumbiner, C Curtis, C S Daly, Cancer Genome Atlas N, CR Jarrett, CV Dang, D Sarrió, DJ Liao, DM Roberts, E López-Knowles, FC Geyer, G T Williams, H Clevers, H Clevers, H Clevers, I Van der Auwera, J H Van Es, J Quist, J Schneikert, J Watkins, JH van Es, JI Herschkowitz, JI Yook, JN Hutchinson, JS Michaelson, K Aoki, K Bray, K Furuuchi, K R Reed, K Umeda, K Wang, KY Ho, L D Ordonez, M Dolled-Filhart, M Jönsson, M Kashiwaba, M Reichert, M van der Meer, MM Suzuki, OJ Sansom, P Shaw, PW Schlosshauer, RA Neese, RC Gallagher, RS Chapman, S Irshad, S Khalil, S Mohinta, S Nelson, S Selbert, SB Sobottka, SJ Zardawi, SY Lin, TA Chan, TA DiMeo, TC He, TL Yang, TM Williams, Y Ahmed, Y Ando-Akatsuka, Z Jin, ZJ Wang   +72 more
core   +1 more source

Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein [PDF]

Molecular and Cellular Biology, 2001
Loss of functional adenomatous polyposis coli protein (APC) leads to uncontrolled proliferation of colonic epithelial cells, as evidenced by polyp formation, a prelude to carcinogenesis. As a tumor suppressor, APC targets the oncogene beta-catenin for proteasome-mediated cytoplasmic degradation.
F, Zhang, R L, White, K L, Neufeld
openaire   +2 more sources

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Sildenafil enhances neurogenesis and oligodendrogenesis in ischemic brain of middle-aged mouse. [PDF]

PLoS ONE, 2012
Adult neural stem cells give rise to neurons, oligodendrocytes and astrocytes. Aging reduces neural stem cells. Using an inducible nestin-CreER(T2)/R26R-yellow fluorescent protein (YFP) mouse, we investigated the effect of Sildenafil, a phosphodiesterase
Rui Lan Zhang, Michael Chopp, Cynthia Roberts, Min Wei, Xinli Wang, Xianshuang Liu, Mei Lu, Zheng Gang Zhang   +7 more
doaj   +1 more source

Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene

Microbiology Spectrum, 2022
Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC.
Jawara Allen, Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Shaoguang Wu, Xinqun Wu, Charelle Boot, Aurelia Saftien, Heather M. O’Hagan, Hao Wang, Ruben van Boxtel, Hans Clevers, Cynthia L. Sears   +12 more
doaj   +1 more source

Interaction between Ku80 protein and a widely used antibody to adenomatous polyposis coli [PDF]

British Journal of Cancer, 2003
The adenomatous polyposis coli (APC) gene and its expressed product are highly studied because of its role as a tumour-suppressor protein. Inherited mutations in APC lead to the condition known as familial adenomatous polyposis (FAP), which predisposes the affected individuals to colorectal cancer.
Roberts, G T, Davies, M L, Wakeman, J A
openaire   +2 more sources