Results 71 to 80 of about 24,916 (232)

Chromosomal localization and promoter analysis of the adenomatous polyposis coli binding protein RP1 [PDF]

Oncogene, 2001
The EB1/RP1 family is a new protein family that is characterized by the ability of its members to serve as interacting partners for the adenomatous polyposis coli (APC) tumour suppressor protein and tubulin. Data obtained with highly conserved yeast homologues suggest that the EB1/RP1 protein family promotes cytoplasmic microtubule dynamics and ...
A, Wadle, G, Thiel, A, Mischo, V, Jung, M, Pfreundschuh, C, Renner   +5 more
openaire   +2 more sources

Sildenafil enhances neurogenesis and oligodendrogenesis in ischemic brain of middle-aged mouse. [PDF]

PLoS ONE, 2012
Adult neural stem cells give rise to neurons, oligodendrocytes and astrocytes. Aging reduces neural stem cells. Using an inducible nestin-CreER(T2)/R26R-yellow fluorescent protein (YFP) mouse, we investigated the effect of Sildenafil, a phosphodiesterase
Rui Lan Zhang, Michael Chopp, Cynthia Roberts, Min Wei, Xinli Wang, Xianshuang Liu, Mei Lu, Zheng Gang Zhang   +7 more
doaj   +1 more source

Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene

Microbiology Spectrum, 2022
Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC.
Jawara Allen, Axel Rosendahl Huber, Cayetano Pleguezuelos-Manzano, Jens Puschhof, Shaoguang Wu, Xinqun Wu, Charelle Boot, Aurelia Saftien, Heather M. O’Hagan, Hao Wang, Ruben van Boxtel, Hans Clevers, Cynthia L. Sears   +12 more
doaj   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Adenomatous Polyposis Coli-Mediated Accumulation of Abasic DNA Lesions Lead to Cigarette Smoke Condensate-Induced Neoplastic Transformation of Normal Breast Epithelial Cells

Neoplasia: An International Journal for Oncology Research, 2013
Adenomatous polyposis coli (APC) is a multifunctional protein having diverse cellular functions including cell migration, cell-cell adhesion, cell cycle control, chromosomal segregation, and apoptosis.
Aruna S. Jaiswal, Harekrushna Panda, Christine A. Pampo, Dietmar W. Siemann, C. Gary Gairola, Robert Hromas, Satya Narayan   +6 more
doaj   +1 more source

Structure of the human discs large 1 PDZ2- adenomatous polyposis coli cytoskeletal polarity complex: insight into peptide engagement and PDZ clustering. [PDF]

PLoS ONE, 2012
The membrane associated guanylate kinase (MAGUK) family member, human Discs Large 1 (hDlg1) uses a PDZ domain array to interact with the polarity determinant, the Adenomatous Polyposis Coli (APC) microtubule plus end binding protein.
Kevin C Slep
doaj   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

Multivalent Interaction of Beta-Catenin With its Intrinsically Disordered Binding Partner Adenomatous Polyposis Coli

Frontiers in Molecular Biosciences, 2022
The Wnt signalling pathway plays key roles in cell proliferation, differentiation and fate decisions in embryonic development and maintenance of adult tissues, and the twelve Armadillo (ARM) repeat-containing protein β-catenin acts as the signal ...
Pamela J. E. Rowling, Ben L. Murton, Zhen Du, Laura S. Itzhaki   +3 more
doaj   +1 more source

Demographic and Clinical Characteristics of Early‐Onset Colorectal Cancer in Sweden and Finland: A Multicentre Retrospective Cohort Study Over Three Decades

Journal of Surgical Oncology, EarlyView.
ABSTRACT Colorectal cancer is the third most common cancer worldwide, and the proportion of individuals diagnosed under the age of 50 years, referred to as early‐onset colorectal cancer (EOCRC), is increasing. The aim of this study was to evaluate how the demographic and clinical features of EOCR in northern Sweden and Finland have changed over time ...
Melina Charalambidi, Tanja Hukkinen, Tuomas Kaprio, Sofia Edin, Mats Hjortborg, Cecilia Williams, Jaana Hagström, Caj Haglund, Richard Palmqvist, Karin Strigård, Camilla Böckelman, Ioannis Gkekas   +11 more
wiley   +1 more source

RP1 is a phosphorylation target of CK2 and is involved in cell adhesion [PDF]

, 2013
RP1 (synonym: MAPRE2, EB2) is a member of the microtubule binding EB1 protein family, which interacts with APC, a key regulatory molecule in the Wnt signalling pathway.
Renner, Christoph, Frank Stenner, Kleber Sascha, Göttig Stephan, Andreas Wadle (24358), Christoph Renner, Frank Stenner (24360), Alexander Knuth, Axel Mischo, Er Knuth, Stefan Bauer (24356), Zweifel, Martin, Michael Faust, Stephan Göttig (430017), Bauer, Stefan, Andreas Wadle, Faust Michael, Sascha Kleber (24359), Knuth, Alexander, Martin Zweifel, Martin Zweifel (430020), Heike Liewen, Mischo Axel, Stephan Göttig, Michael Faust (331617), Christoph Renner (24366), Markuly Norbert, Zweifel Martin, Stenner Frank, Wadle, Andreas, Kleber, Sascha, Markuly, Norbert, Axel Mischo (430019), Norbert Markuly, Reinhard Henschler (369547), Wadle Andreas, Norbert Markuly (430018), Liewen Heike, Henschler Reinhard, Alexander Knuth (11104), Heike Liewen (430016), Göttig, Stephan, Stenner, Frank, Sascha Kleber, Bauer Stefan, Renner Christoph, Reinhard Henschler, Liewen, Heike, Faust, Michael, Mischo, Axel, Stefan Bauer, Henschler, Reinhard, Knuth Alexander   +52 more
core   +1 more source