Results 91 to 100 of about 30,293 (217)
Cancer Cell International, 2022 Background Colon cancer is often driven by mutations of the adenomatous polyposis coli (APC) gene, an essential tumor suppressor gene of the Wnt β-catenin signaling pathway. APC and its cytoplasmic interactions have been well studied.
Nayra M. Al-Thani +4 more
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Bacterial translocation and barrier dysfunction enhance colonic tumorigenesis
Neoplasia: An International Journal for Oncology Research, 2023 In the development of colon cancer, the intestinal dysbiosis and disruption of barrier function are common manifestations. In the current study, we hypothesized that host factors, e.g., vitamin D receptor deficiency or adenomatous polyposis coli (APC ...
Yongguo Zhang +3 more
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The Journal of Physiology, EarlyView.Abstract figure legend Fetal growth restriction (FGR) is a common pregnancy complication associated with long‐term neurodevelopmental impairments. Using the reduced uterine perfusion pressure (RUPP) rat model of placental insufficiency‐induced FGR, this study demonstrates that FGR leads to persistent anatomical, histological and behavioural ...
Judit Alhama‐Riba +8 more
wiley +1 more source
MACF1 promotes preosteoblast migration by mediating focal adhesion turnover through EB1
Biology Open, 2020 Microtubule actin crosslinking factor 1 (MACF1) is a widely expressed cytoskeletal linker and plays an essential role in various cells’ functions by mediating cytoskeleton organization and dynamics.
Peihong Su +7 more
doaj +1 more source
Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. [PDF]
, 2003 The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E.
Corpet, Denis E., Pierre, Fabrice
core +2 more sources
Novel APC promoter and exon 1B deletion and allelic silencing in three mutation-negative classic familial adenomatous polyposis families [PDF]
, 2015 BACKGROUND: The overwhelming majority (approximately 80%) of individuals with classic familial adenomatous polyposis (FAP) exhibit mutations in the coding sequence of the adenomatous polyposis coli (APC) tumor suppressor gene. Families without detectable
Baxter, Melanie D +8 more
core +2 more sources
Axin-dependent Phosphorylation of the Adenomatous Polyposis Coli Protein Mediated by Casein Kinase 1ε [PDF]
Journal of Biological Chemistry, 2001 Axin and the adenomatous polyposis coli protein (APC) interact to down-regulate the proto-oncogene beta-catenin. We show that transposition of an axin-binding site can confer beta-catenin regulatory activity to a fragment of APC normally lacking this activity.
B, Rubinfeld, D A, Tice, P, Polakis
openaire +2 more sources
International Journal of Cancer, Volume 159, Issue 1, Page 144-158, 1 July 2026.What's New? Unraveling the networks that regulate androgen receptor (AR) function is critical to better understanding prostate cancer development and progression. Of particular interest in this regard is the long non‐coding RNA PVT1, which regulates gene expression in cancer and is upregulated in prostate tumors.
Maria Gabriela Berzoti‐Coelho +7 more
wiley +1 more source
Scientific Reports, 2021 Adenomatous polyposis coli (APC) is a tumor-suppressing protein whose inactivation triggers the formation of colorectal polyps. Numerous studies using cell lines or genetically engineered mice have revealed its role in suppressing Wnt/β-catenin signaling
Daisuke Yamazaki +4 more
doaj +1 more source
Aberrant WNT/β-catenin signaling in parathyroid carcinoma [PDF]
, 2010 Background Parathyroid carcinoma (PC) is a very rare malignancy with a high tendency to recur locally, and recurrent disease is difficult to eradicate. In most western European countries and United States, these malignant neoplasms cause less than 1% of ...
Jessica Svedlund +6 more
core +1 more source