Results 101 to 110 of about 30,293 (217)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, Volume 20, Issue 5, Page 1364-1378, May 2026.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Desmoplastic fibroma of the mandible: a rare gnathic bone tumor with a review of the literature

Autopsy and Case Reports, 2019
Desmoplastic fibroma (DF) is a rare bone tumor, which is known to involve mostly the gnathic bones. In this setting, the clinical presentation is usually represented by a bulging tumor of the face. Radiologically, the tumor is usually characterized by an
Manoj Gopal Madakshira, Amanjit Bal, Roshan Kumar Verma   +2 more
doaj   +1 more source

A specific upregulated long noncoding RNA in colorectal cancer promotes cancer progression

JCI Insight, 2022
Long noncoding RNA (lncRNA) plays a crucial role in the pathogenesis of various diseases, including colorectal cancer (CRC). The gene mutations of adenomatous polyposis coli (APC) were found in most patients with CRC.
Junshu Li, Yanhong Ji, Na Chen, Huiling Wang, Chao Fang, Xiaonan Yin, Zhiyuan Jiang, Zhexu Dong, Dan Zhu, Jiamei Fu, Wencheng Zhou, Ruiyi Jiang, Ling He, Zhang Hantao, Gang Shi, Lin Cheng, Xiaolan Su, Lei Dai, Hongxin Deng   +18 more
doaj   +1 more source

Characterization of a 60S complex of the adenomatous polyposis coli tumor suppressor protein

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2007
The tumor suppressor protein adenomatous polyposis coli (APC) is a multifunctional protein with a well characterized role in the Wnt signal transduction pathway and roles in cytoskeletal regulation and cell polarity. The soluble pool of APC protein in colon epithelial tumor cells exists in two distinct complexes fractionating at approximately 20S and ...
Mahadevaiyer, Sreekala, Xu, Chong, Gumbiner, Barry M.   +2 more
openaire   +2 more sources

Reduced Oligodendrocyte Density and Axonal Caliber Associated With Mitochondrial Alterations in the White Matter of Chronically‐Starved Mice

International Journal of Eating Disorders, Volume 59, Issue 5, Page 869-884, May 2026.
ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with extreme weight loss, hyperactivity, and amenorrhea. Neuroimaging studies revealed brain atrophy and disruption of white matter integrity in the corpus callosum (CC) of patients with AN. However, the underlying pathophysiological mechanisms remain unclear.
Stephan Lang, Annelie Zimmermann, Kaja Dickert, Hanna Rupprecht, Julia Priebe, Fabienne Haberland, Hanna‐Sophia Henschke, Katharina Schuster, Marcus Frank, Linda Frintrop   +9 more
wiley   +1 more source

Clinical characterization and the mutation spectrum in Swedish adenomatous polyposis families [PDF]

, 2008
Background: The dominantly inherited condition familial adenomatous polyposis (FAP) is caused by germline mutations in the APC gene. Finding the causative mutations has great implications for the families.
Gunilla Kanter-Smoler, Kaisa Fritzell, Anna Rohlin, Yvonne Engwall, Birgitta Hallberg, Annika Bergman, Johan Meuller, Henrik Grönberg, Per Karlsson, Jan Björk, Margareta Nordling, J Groden, KW Kinzler, L Lipton, N Al-Tassan, S Jones, NS Fearnhead, IS Nathke, ET Renkonen, OM Sieber, J Meuller, S Aretz, G Michils, L Varesco, YL Wallis, GS Charames, S Aretz, DW Neklason, SJ Laken, SM Powell, H Yan, T Venesio, SM Powell, SM Farrington, S Aretz, FJ Hes, P Galiatsatos, HJ Jarvinen, ML Bisgaard, AL Knudsen, J Bjork, G Kanter-Smoler, Z Einbeigi, J Bjork, JP Schouten, MH Nieuwenhuis, PD Stenson, G Joslyn, ML Bisgaard, MH Nieuwenhuis, K Heppner Goss, M Mandl, L Kluwe, S Pedemonte, MO Hiltunen, M Esteller, G Deng, CN Arnold, I Gazzoli, CM Suter, W Friedl, Y Miyoshi, H Lamlum, AL Moisio, H Nagase, R Ripa, S Olschwang, M Miyaki, B Truta, RB van der Luijt, JR Garcia-Lozano, P Paul, M Nilbert, Z Dobbie, S Norheim Andersen   +74 more
core   +2 more sources

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

An APC:WNT Counter-Current-Like Mechanism Regulates Cell Division Along the Human Colonic Crypt Axis: A Mechanism That Explains How APC Mutations Induce Proliferative Abnormalities That Drive Colon Cancer Development. [PDF]

, 2013
APC normally down-regulates WNT signaling in human colon, and APC mutations cause proliferative abnormalities in premalignant crypts leading to colon cancer, but the mechanisms are unclear at the level of spatial and functional organization of the crypt.
Boman, Bruce M, Fields, Jeremy Z
core   +1 more source

Innate Lymphoid Cells in Tissue Homeostasis and Diseases

MedComm, Volume 7, Issue 5, May 2026.
Innate lymphoid cells (ILCs) are a heterogeneous group of immune cells with phenotypic and functional plasticity. ILCs dynamically regulate various immune cell types and play a crucial role in the pathophysiological processes of specific organs during sepsis. Targeting ILCs is a promising strategy for treating sepsis.
Zhenzhen Zhan, Heyang Sun, Chenning Li, Qianya Hong, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo   +7 more
wiley   +1 more source

APC selectively mediates response to chemotherapeutic agents in breast cancer [PDF]

, 2015
BACKGROUND: The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated or hypermethylated in up to 70 % of sporadic breast cancers depending on subtype; however, the effects of APC mutation on tumorigenic properties remain unexplored. Using the Apc(
Claire O. Bedalov, Jenifer R. Prosperi, Katia Fernandez Soto, Monica K. VanKlompenberg   +3 more
core   +3 more sources