Results 51 to 60 of about 24,916 (232)

RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells

Molecular Oncology, 2022
Ribosomal biogenesis and protein synthesis are deregulated in most cancers, suggesting that interfering with translation machinery may hold significant therapeutic potential. Here, we show that loss of the tumor suppressor adenomatous polyposis coli (APC)
Christoph Otto, Carolin Kastner, Stefanie Schmidt, Konstantin Uttinger, Apoorva Baluapuri, Sarah Denk, Mathias T. Rosenfeldt, Andreas Rosenwald, Florian Roehrig, Carsten P. Ade, Christina Schuelein‐Voelk, Markus E. Diefenbacher, Christoph‐Thomas Germer, Elmar Wolf, Martin Eilers, Armin Wiegering   +15 more
doaj   +1 more source

Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations

Cell Reports, 2021
Summary: Colorectal cancer (CRC) is one of the most common cancers worldwide, in which adenomatous polyposis coli (APC) mutations are frequently and uniquely observed.
Zhenzhen Chen, Jiayi Wu, Benyu Liu, Guangtan Zhang, Zhiwei Wang, Lulu Zhang, Kaili Wang, Zusen Fan, Pingping Zhu   +8 more
doaj   +1 more source

Adenomatous Polyposis Coli as a Scaffold for Microtubule End-Binding Proteins

Journal of Molecular Biology, 2019
End-binding proteins (EBs), referred to as the core components of the microtubule plus-end tracking protein network, interact with the C-terminus of the adenomatous polyposis coli (APC) tumor suppressor. This interaction is disrupted in colon cancers expressing truncated APC.
Serre, Laurence, Stoppin-Mellet, Virginie, Arnal, Isabelle   +2 more
openaire   +5 more sources

Interaction between Ku80 protein and a widely used antibody to adenomatous polyposis coli [PDF]

British Journal of Cancer, 2003
The adenomatous polyposis coli (APC) gene and its expressed product are highly studied because of its role as a tumour-suppressor protein. Inherited mutations in APC lead to the condition known as familial adenomatous polyposis (FAP), which predisposes the affected individuals to colorectal cancer.
Roberts, G T, Davies, M L, Wakeman, J A
openaire   +2 more sources

APCI1307K Mutations and Forkhead Box Gene (FOXO1A): Another Piece of an Interesting Correlation

The International Journal of Biological Markers, 2012
Purpose Germline nonsense and frameshift mutations in the adenomatous polyposis coli (APC) gene are found in approximately 90% of individuals affected by familial adenomatous polyposis (FAP) and a genotype-phenotype relationship has been observed ...
Marco Agostini, Chiara Bedin, Salvatore Pucciarelli, Mariavittoria Enzo, Marta Briarava, Roberta Seraglia, Eugenio Ragazzi, Pietro Traldi, Laura Molin, Emanuele Damiano Urso, Isabella Mammi, Alessandra Viel, Mario Lise, Ennio Tasciotti, Alessandra Biasiolo, Patrizia Pontisso, Donato Nitti   +16 more
doaj   +1 more source

APC-driven actin nucleation powers collective cell dynamics in colorectal cancer cells

iScience, 2023
Summary: Cell remodeling relies on dynamic rearrangements of cell contacts powered by the actin cytoskeleton. The tumor suppressor adenomatous polyposis coli (APC) nucleate actin filaments (F-actin) and localizes at cell junctions.
Lautaro Baro, Asifa Islam, Hannah M. Brown, Zoë A. Bell, M. Angeles Juanes   +4 more
doaj   +1 more source

Fruits, vegetables, and hMLH1 protein-deficient and -proficient colon cancer: The Netherlands cohort study. [PDF]

, 2005
BACKGROUND: Clinical and pathologic differences exist between colon carcinomas deficient and proficient in the mismatch repair protein hMLH1. Animal and in vitro studies suggest that fruits, vegetables, folate, and antioxidants are associated with ...
Brandt, P.A. van den, van Wijhe, G., van Muijen, Goos NP, Goldbohm, R.A., van Wijhe, Gerda, Goldbohm, R Alexandra, Muijen, G.N.P. van, van den Brandt, Piet A, Wijhe, G. van, Wark, Petra A.; id_orcid, Goldbohm, R. Alexandra, Van Muijen, Goos N P, Van Den Brandt, Piet A., Veer, P. van 't, van 't Veer, Pieter, Weijenberg, Matty P., Weijenberg, Matty P, de Goeij, Anton FPM, Wark, P.A., De Goeij, Anton F P M, van Muijen, G.N.P., van 't Veer, P., van den Brandt, P.A., Luchtenborg, M., Goeij, A.F.P.M. de, Goeij, A.F. de, Weijenberg, M.P., Wark, Petra A, Lüchtenborg, Margreet, de Goeij, A.F., de Goeij, A.F.P.M., Van't Veer, Pieter   +31 more
core   +1 more source

Germline Missense Changes in the APC Gene and Their Relationship to Disease

Hereditary Cancer in Clinical Practice, 2004
Familial adenomatous polyposis (FAP) is characterized by the presence of hundreds to thousands of adenomas that carpet the entire colon and rectum. Nonsense and frameshift mutations in the adenomatous polyposis coli (APC) gene account for the majority of
Scott Rodney J, Crooks Renee, Rose Lindy, Attia John, Thakkinstian Ammarin, Thomas Lesley, Spigelman Allan D, Meldrum Cliff J   +7 more
doaj   +1 more source

Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients

BMC Cancer, 2005
Background Familial Adenomatous Polyposis (FAP) is caused by germline mutations in the APC (Adenomatous Polyposis Coli) gene. The vast majority of APC mutations are point mutations or small insertions / deletions which lead to truncated protein products.
Danielidis Ioannis, Triantafillidis John K, Petropoulos Konstantinos, Koliopanos Alexander, Psychias Aristidis, Velissariou Voula, Dauwerse Hans, Apessos Angela, Mihalatos Markos, Fountzilas George, Agnantis Niki J, Nasioulas Georgios   +11 more
doaj   +1 more source

The Ubiquitin-Proteasome Pathway and Serine Kinase Activity Modulate Adenomatous Polyposis Coli Protein-mediated Regulation of β-Catenin-Lymphocyte Enhancer-binding Factor Signaling*

Journal of Biological Chemistry, 1999
The tumor suppressor function of the adenomatous polyposis coli protein (APC) depends, in part, on its ability to bind and regulate the multifunctional protein, β-catenin.
V. Easwaran, Virginia Song, P. Polakis, S. Byers   +3 more
semanticscholar   +1 more source