Results 51 to 60 of about 30,293 (217)

Germline Missense Changes in the APC Gene and Their Relationship to Disease

Hereditary Cancer in Clinical Practice, 2004
Familial adenomatous polyposis (FAP) is characterized by the presence of hundreds to thousands of adenomas that carpet the entire colon and rectum. Nonsense and frameshift mutations in the adenomatous polyposis coli (APC) gene account for the majority of
Scott Rodney J, Crooks Renee, Rose Lindy, Attia John, Thakkinstian Ammarin, Thomas Lesley, Spigelman Allan D, Meldrum Cliff J   +7 more
doaj   +1 more source

A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. [PDF]

, 2011
The unique architecture of neurons requires the establishment and maintenance of polarity, which relies in part on microtubule-based transport to deliver essential cargo into dendrites.
Goldstein, Lawrence SB, Henthorn, Kristina Schimmelpfeng, Herrera, Cheryl, Roux, Meike Sabina   +3 more
core   +2 more sources

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1 [PDF]

Journal of Cell Biology, 2010
The tumor suppressor protein adenomatous polyposis coli (APC) regulates cell protrusion and cell migration, processes that require the coordinated regulation of actin and microtubule dynamics. APC localizes in vivo to microtubule plus ends and actin-rich cortical protrusions, and has well-documented direct effects on microtubule dynamics.
Okada, Kyoko, Bartolini, Francesca, Deaconescu, Alexandra M., Moseley, James B., Dogic, Zvonimir, Grigorieff, Nikolaus, Gundersen, Gregg G., Goode, Bruce L.   +7 more
openaire   +2 more sources

Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients

BMC Cancer, 2005
Background Familial Adenomatous Polyposis (FAP) is caused by germline mutations in the APC (Adenomatous Polyposis Coli) gene. The vast majority of APC mutations are point mutations or small insertions / deletions which lead to truncated protein products.
Danielidis Ioannis, Triantafillidis John K, Petropoulos Konstantinos, Koliopanos Alexander, Psychias Aristidis, Velissariou Voula, Dauwerse Hans, Apessos Angela, Mihalatos Markos, Fountzilas George, Agnantis Niki J, Nasioulas Georgios   +11 more
doaj   +1 more source

Expression Profiling of Proliferation and Apoptotic Markers along the Adenoma-Carcinoma Sequence in Familial Adenomatous Polyposis Patients

Gastroenterology Research and Practice, 2013
Introduction. Familial adenomatous polyposis (FAP) patients have a germline mutation in the adenomatous polyposis coli (APC) gene. The APC protein interacts with beta-catenin, resulting in the activation of the Wnt signalling pathway.
Jayson Wang, Nabil El-Masry, Ian Talbot, Ian Tomlinson, Malcolm R. Alison, Mona El-Bahrawy   +5 more
doaj   +1 more source

Mammalian diaphanous-related formin 1 regulates GSK3β-dependent microtubule dynamics required for T cell migratory polarization. [PDF]

PLoS ONE, 2013
The mammalian diaphanous-related formin (mDia1), a Rho-regulated cytoskeletal modulator, has been shown to promote T lymphocyte chemotaxis and interaction with antigen presenting cells, but the mechanisms underpinning mDia1 roles in these processes have ...
Baoxia Dong, Steven S Zhang, Wen Gao, Haichun Su, Jun Chen, Fuzi Jin, Ajay Bhargava, Xiequn Chen, Lars Jorgensen, Arthur S Alberts, Jinyi Zhang, Katherine A Siminovitch   +11 more
doaj   +1 more source

Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis [PDF]

, 2012
Familial adenomatous polyposis (FAP) is an autosomal dominant cancer predisposition syndrome that accounts for approximately 0.5–1% of all colorectal cancer cases.
Abraham, Abraham, Aoki, Belchetz, Bertario, Blaker, Boerboom, Bonnet, Curia, Ellison, Fearon, Galle, Garcia-Rostan, Gaujoux, Groden, Groves, Half, Hamilton, Hayes, Hosogi, Ilyas, Korinek, Kurahashi, Lazar, Marchesa, Miyaki, Miyaki, Miyaki, Miyoshi, Morin, Nishisho, Scully, Segditsas, Shah, Smith, Stratakis, Wakatsuki   +36 more
core   +1 more source

Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein [PDF]

Proceedings of the National Academy of Sciences, 2000
Mutation of the adenomatous polyposis coli ( APC ) gene is an early step in the development of colorectal carcinomas. APC protein is located in both the cytoplasm and the nucleus. The objective of this study was to define the nuclear localization signals (NLSs) in APC protein.
F, Zhang, R L, White, K L, Neufeld
openaire   +2 more sources

Mouse models of colorectal cancer. [PDF]

, 2011
Colorectal cancer is one of the most common malignancies in the world. Many mouse models have been developed to evaluate features of colorectal cancer in humans. These can be grouped into genetically-engineered, chemically-induced, and inoculated models.
Koeffler, H Phillip, Tong, Yunguang, Yang, Wancai   +2 more
core   +2 more sources

Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance [PDF]

Journal of Cell Science, 2013
Since its discovery as the major tumour suppressor in colorectal cancer, the adenomatous polyposis coli (APC) protein has emerged as a multi-functional protein that directly or indirectly regulates the cellular processes that govern epithelial tissues ([McCartney and Nathke, 2008][1]).
Nelson, Scott, Näthke, Inke S.
openaire   +3 more sources