Results 31 to 40 of about 17,976 (173)

Adenomatous polyposis coli-binding protein end-binding 1 promotes hepatocellular carcinoma growth and metastasis.

PLoS ONE, 2020
This study was performed to determine the clinical significance of adenomatous polyposis coli (APC)-binding protein end-binding 1 (EB1) in hepatocellular carcinoma (HCC) and to characterize its biochemical role in comparison with previous reports.
Takeshi Aiyama, Tatsuya Orimo, Hideki Yokoo, Takanori Ohata, Kanako C Hatanaka, Yutaka Hatanaka, Moto Fukai, Toshiya Kamiyama, Akinobu Taketomi   +8 more
doaj   +1 more source

Targeting Stem Cell Behavior in Desmoid Tumors (Aggressive Fibromatosis) by Inhibiting Hedgehog Signaling

Neoplasia: An International Journal for Oncology Research, 2013
Desmoid tumor (also called aggressive fibromatosis) is a lesion of mesenchymal origin that can occur as a sporadic tumor or a manifestation of the preneoplastic syndrome, familial adenomatous polyposis caused by a mutation in adenomatous polyposis coli ...
Ronak Ghanbari-Azarnier, Shingo Sato, Qingxia Wei, Mushriq Al-Jazrawe, Benjamin A. Alman   +4 more
doaj   +1 more source

Small molecule-induced destabilization of β-catenin and RAS is the ideal strategies for suppressing colorectal cancer [PDF]

Organoid, 2023
Background Mutations of adenomatous polyposis coli (APC) and KRAS play essential roles in the development of colorectal cancer (CRC) by forming an abnormal colon morphology.
Yonghyo Kim, Myoung-Hee Kang, Geon-Woo Kim, Yong-Hee Cho   +3 more
doaj   +1 more source

RNA polymerase I inhibition induces terminal differentiation, growth arrest, and vulnerability to senolytics in colorectal cancer cells

Molecular Oncology, 2022
Ribosomal biogenesis and protein synthesis are deregulated in most cancers, suggesting that interfering with translation machinery may hold significant therapeutic potential. Here, we show that loss of the tumor suppressor adenomatous polyposis coli (APC)
Christoph Otto, Carolin Kastner, Stefanie Schmidt, Konstantin Uttinger, Apoorva Baluapuri, Sarah Denk, Mathias T. Rosenfeldt, Andreas Rosenwald, Florian Roehrig, Carsten P. Ade, Christina Schuelein‐Voelk, Markus E. Diefenbacher, Christoph‐Thomas Germer, Elmar Wolf, Martin Eilers, Armin Wiegering   +15 more
doaj   +1 more source

Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein [PDF]

Proceedings of the National Academy of Sciences, 2002
Mutations in the adenomatous polyposis coli ( APC ) gene are responsible for familial adenomatous polyposis coli and also sporadic colorectal cancer development. By using antibodies raised against the N-terminal region of APC protein, we have detected the variable masses of endogenous APC ...
Miwako Kato, Homma, Dongxia, Li, Edwin G, Krebs, Yasuhito, Yuasa, Yoshimi, Homma   +4 more
openaire   +2 more sources

Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations

Cell Reports, 2021
Summary: Colorectal cancer (CRC) is one of the most common cancers worldwide, in which adenomatous polyposis coli (APC) mutations are frequently and uniquely observed.
Zhenzhen Chen, Jiayi Wu, Benyu Liu, Guangtan Zhang, Zhiwei Wang, Lulu Zhang, Kaili Wang, Zusen Fan, Pingping Zhu   +8 more
doaj   +1 more source

APCI1307K Mutations and Forkhead Box Gene (FOXO1A): Another Piece of an Interesting Correlation

The International Journal of Biological Markers, 2012
Purpose Germline nonsense and frameshift mutations in the adenomatous polyposis coli (APC) gene are found in approximately 90% of individuals affected by familial adenomatous polyposis (FAP) and a genotype-phenotype relationship has been observed ...
Marco Agostini, Chiara Bedin, Salvatore Pucciarelli, Mariavittoria Enzo, Marta Briarava, Roberta Seraglia, Eugenio Ragazzi, Pietro Traldi, Laura Molin, Emanuele Damiano Urso, Isabella Mammi, Alessandra Viel, Mario Lise, Ennio Tasciotti, Alessandra Biasiolo, Patrizia Pontisso, Donato Nitti   +16 more
doaj   +1 more source

APC-driven actin nucleation powers collective cell dynamics in colorectal cancer cells

iScience, 2023
Summary: Cell remodeling relies on dynamic rearrangements of cell contacts powered by the actin cytoskeleton. The tumor suppressor adenomatous polyposis coli (APC) nucleate actin filaments (F-actin) and localizes at cell junctions.
Lautaro Baro, Asifa Islam, Hannah M. Brown, Zoë A. Bell, M. Angeles Juanes   +4 more
doaj   +1 more source

Adenomatous Polyposis Coli as a Scaffold for Microtubule End-Binding Proteins

Journal of Molecular Biology, 2019
End-binding proteins (EBs), referred to as the core components of the microtubule plus-end tracking protein network, interact with the C-terminus of the adenomatous polyposis coli (APC) tumor suppressor. This interaction is disrupted in colon cancers expressing truncated APC.
Serre, Laurence, Stoppin-Mellet, Virginie, Arnal, Isabelle   +2 more
openaire   +5 more sources

Germline Missense Changes in the APC Gene and Their Relationship to Disease

Hereditary Cancer in Clinical Practice, 2004
Familial adenomatous polyposis (FAP) is characterized by the presence of hundreds to thousands of adenomas that carpet the entire colon and rectum. Nonsense and frameshift mutations in the adenomatous polyposis coli (APC) gene account for the majority of
Scott Rodney J, Crooks Renee, Rose Lindy, Attia John, Thakkinstian Ammarin, Thomas Lesley, Spigelman Allan D, Meldrum Cliff J   +7 more
doaj   +1 more source