Results 21 to 30 of about 17,976 (173)

Identification of a novel CNV at the APC gene in a Chinese family with familial adenomatous polyposis

Frontiers in Molecular Biosciences, 2023
Introduction: Familial adenomatous polyposis (FAP) is the second most commonly inherited colorectal cancer (CRC) predisposition caused by germline mutations within the adenomatous polyposis coli (APC) gene.
Juyi Li, Chengzhi He, Jing Gong, Xiufang Wang, Chao Liu, Aiping Deng, Lin Zhu   +6 more
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Immunopurification of adenomatous polyposis coli (APC) proteins [PDF]

BMC Research Notes, 2013
AbstractBackgroundTheadenomatous polyposis coli(APC) tumour suppressor gene encodes a 2843 residue (310 kDa) protein. APC is a multifunctional protein involved in the regulation of β-catenin/Wnt signalling, cytoskeletal dynamics and cell adhesion.APCmutations occur in most colorectal cancers and typically result in truncation of the C-terminal half of ...
Elliott, KL, Catimel, B, Church, NL, Coates, JL, Burgess, AW, Layton, MJ, Faux, MC   +6 more
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Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype

Canadian Journal of Gastroenterology and Hepatology, 2021
A large number of colorectal cancers have a genetic background in China. However, due to insufficient awareness, the diagnostic rate remains low and merely 5-6% of colorectal cancer patients are diagnosed with hereditary colorectal cancer.
Li-jun Xie, Dan-dan Ruan, Jian-hui Zhang, Yi Li, Li Chen, Mao-lin Yan, Ming-dian Yu, Jie-wei Luo, Hui-zhen Zhang   +8 more
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Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer

Frontiers in Oncology, 2022
BackgroundMutations in the tumor suppressor gene Adenomatous Polyposis Coli (APC) are found in 80% of sporadic colorectal cancer (CRC) tumors and are also responsible for the inherited form of CRC, Familial adenomatous polyposis (FAP).MethodsTo identify ...
Hannah Shailes, Wai Yiu Tse, Marta O. Freitas, Andrew Silver, Sarah A. Martin   +4 more
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Regulated Binding of Adenomatous Polyposis Coli Protein to Actin [PDF]

Journal of Biological Chemistry, 2007
Adenomatous polyposis coli (APC) protein is a large tumor suppressor that is truncated in most colorectal cancers. The carboxyl-terminal third of APC protein mediates direct interactions with microtubules and the microtubule plus-end tracking protein EB1.
James B, Moseley, Francesca, Bartolini, Kyoko, Okada, Ying, Wen, Gregg G, Gundersen, Bruce L, Goode   +5 more
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Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein [PDF]

Proceedings of the National Academy of Sciences, 1997
Mutation of the adenomatous polyposis coli ( APC ) gene is an early step in the initiation of colon cancer. Because the distribution pattern of a protein within the cell can provide important clues as to function, we have used a combination of immunofluorescence microscopy and biochemical ...
K L, Neufeld, R L, White
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An APC Mutation in a Large Chinese Kindred With Familial Adenomatous Polyposis Was Identified Using Both Next Generation Sequencing and Simple STR Marker Haplotypes

Frontiers in Genetics, 2020
BackgroundFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized primarily by the development of numerous adenomatous polyps in the colon and a high risk for colorectal cancer.
Qitao Zhan, Liya Wang, Xiangrong Xu, Yan Sun, Lejun Li, Xuchen Qi, Feng Chen, Xiaoming Wei, Michael L. Raff, Ping Yu, Fan Jin   +10 more
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T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations

Frontiers in Immunology, 2023
Familial adenomatous polyposis (FAP) is an inherited disease characterized by the development of large number of colorectal adenomas with high risk of evolving into colorectal tumors. Mutations of the Adenomatous polyposis coli (APC) gene is often at the
Céline Cuche, Marta Mastrogiovanni, Marta Mastrogiovanni, Marie Juzans, Marie Juzans, Hélène Laude, Marie-Noëlle Ungeheuer, Daniel Krentzel, Maria Isabella Gariboldi, Daniel Scott-Algara, Marianne Madec, Sophie Goyard, Sophie Goyard, Camille Floch, Camille Floch, Gaëlle Chauveau-Le Friec, Pierre Lafaye, Charlotte Renaudat, Muriel Le Bidan, Christine Micallef, Sandrine Schmutz, Sébastien Mella, Sébastien Mella, Sophie Novault, Milena Hasan, Darragh Duffy, Vincenzo Di Bartolo, Andrés Alcover   +27 more
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Adenomatous Polyposis Coli Associates with the Microtubule-Destabilizing Protein XMCAK [PDF]

Current Biology, 2004
During cell division, the proper formation of a bipolar spindle and its function to segregate chromosomes requires precise coordination of microtubule-stabilizing and destabilizing activities. Globally destabilized, dynamic microtubules radiating from duplicated centrosomes are locally regulated by chromosomes.
Banks, Jennifer D., Heald, Rebecca
openaire   +2 more sources

Adenomatous Polyposis Coli (APC) in cell migration

European Journal of Cell Biology, 2022
Adenomatous Polyposis Coli (APC) protein is mostly known as a tumor suppressor that regulates Wnt signaling, but is also an important cytoskeletal protein.
Xingyuan Fang, Tatyana M. Svitkina
doaj   +1 more source