Results 11 to 20 of about 30,293 (217)

Rational design of a sensitivity-enhanced tracer for discovering efficient APC–Asef inhibitors

Nature Communications, 2022
The adenomatous polyposis coli (APC)–Asef protein interaction is essential for colorectal cancer metastasis. Here, the authors present the rational design of a sensitivity-enhanced tracer for fluorescence polarization assays, enabling them to discover ...
Jie Zhong, Yuegui Guo, Shaoyong Lu, Kun Song, Ying Wang, Li Feng, Zhen Zheng, Qiufen Zhang, Jiacheng Wei, Peng Sang, Yan Shi, Jianfeng Cai, Guoqiang Chen, Chen-Ying Liu, Xiuyan Yang, Jian Zhang   +15 more
doaj   +1 more source

Identification of a novel CNV at the APC gene in a Chinese family with familial adenomatous polyposis

Frontiers in Molecular Biosciences, 2023
Introduction: Familial adenomatous polyposis (FAP) is the second most commonly inherited colorectal cancer (CRC) predisposition caused by germline mutations within the adenomatous polyposis coli (APC) gene.
Juyi Li, Chengzhi He, Jing Gong, Xiufang Wang, Chao Liu, Aiping Deng, Lin Zhu   +6 more
doaj   +1 more source

Immunopurification of adenomatous polyposis coli (APC) proteins [PDF]

BMC Research Notes, 2013
AbstractBackgroundTheadenomatous polyposis coli(APC) tumour suppressor gene encodes a 2843 residue (310 kDa) protein. APC is a multifunctional protein involved in the regulation of β-catenin/Wnt signalling, cytoskeletal dynamics and cell adhesion.APCmutations occur in most colorectal cancers and typically result in truncation of the C-terminal half of ...
Elliott, KL, Catimel, B, Church, NL, Coates, JL, Burgess, AW, Layton, MJ, Faux, MC   +6 more
openaire   +3 more sources

Mutational Analysis of a Familial Adenomatous Polyposis Pedigree with Bile Duct Polyp Phenotype

Canadian Journal of Gastroenterology and Hepatology, 2021
A large number of colorectal cancers have a genetic background in China. However, due to insufficient awareness, the diagnostic rate remains low and merely 5-6% of colorectal cancer patients are diagnosed with hereditary colorectal cancer.
Li-jun Xie, Dan-dan Ruan, Jian-hui Zhang, Yi Li, Li Chen, Mao-lin Yan, Ming-dian Yu, Jie-wei Luo, Hui-zhen Zhang   +8 more
doaj   +1 more source

Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer

Frontiers in Oncology, 2022
BackgroundMutations in the tumor suppressor gene Adenomatous Polyposis Coli (APC) are found in 80% of sporadic colorectal cancer (CRC) tumors and are also responsible for the inherited form of CRC, Familial adenomatous polyposis (FAP).MethodsTo identify ...
Hannah Shailes, Wai Yiu Tse, Marta O. Freitas, Andrew Silver, Sarah A. Martin   +4 more
doaj   +1 more source

Regulated Binding of Adenomatous Polyposis Coli Protein to Actin [PDF]

Journal of Biological Chemistry, 2007
Adenomatous polyposis coli (APC) protein is a large tumor suppressor that is truncated in most colorectal cancers. The carboxyl-terminal third of APC protein mediates direct interactions with microtubules and the microtubule plus-end tracking protein EB1.
James B, Moseley, Francesca, Bartolini, Kyoko, Okada, Ying, Wen, Gregg G, Gundersen, Bruce L, Goode   +5 more
openaire   +2 more sources

Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein [PDF]

Proceedings of the National Academy of Sciences, 1997
Mutation of the adenomatous polyposis coli ( APC ) gene is an early step in the initiation of colon cancer. Because the distribution pattern of a protein within the cell can provide important clues as to function, we have used a combination of immunofluorescence microscopy and biochemical fractionation to determine ...
K L, Neufeld, R L, White
openaire   +2 more sources

Adenomatous Polyposis Coli Associates with the Microtubule-Destabilizing Protein XMCAK [PDF]

Current Biology, 2004
During cell division, the proper formation of a bipolar spindle and its function to segregate chromosomes requires precise coordination of microtubule-stabilizing and destabilizing activities. Globally destabilized, dynamic microtubules radiating from duplicated centrosomes are locally regulated by chromosomes.
Banks, Jennifer D., Heald, Rebecca
openaire   +2 more sources

Neurite outgrowth involves adenomatous polyposis coli protein and β-catenin [PDF]

Journal of Cell Science, 2005
Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites. The mechanisms underlying neurite formation are poorly understood. A candidate protein for controlling neurite extension is the adenomatous polyposis coli (APC) protein, which regulates membrane extensions, microtubules and β-
Violet, Votin, W James, Nelson, Angela I M, Barth   +2 more
openaire   +2 more sources

TALEN-mediated apc mutation in Xenopus tropicalis phenocopies familial adenomatous polyposis [PDF]

, 2015
Truncating mutations in the tumor suppressor gene adenomatous polyposis coli (APC) are the initiating step in the vast majority of sporadic colorectal cancers, and they underlie familial adenomatous polyposis (FAP) syndromes.
Creytens, David, Geurs, Sarah, Naert, Thomas, Sanders, Ellen, Tran Thi, Hong, Van Imschoot, Griet, Van Nieuwenhuysen, Tom, Van Roy, Frans, Vleminckx, Kris   +8 more
core   +6 more sources