Results 11 to 20 of about 24,916 (232)

Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1 [PDF]

Journal of Cell Biology, 2010
The tumor suppressor protein adenomatous polyposis coli (APC) regulates cell protrusion and cell migration, processes that require the coordinated regulation of actin and microtubule dynamics. APC localizes in vivo to microtubule plus ends and actin-rich cortical protrusions, and has well-documented direct effects on microtubule dynamics.
Okada, Kyoko, Bartolini, Francesca, Deaconescu, Alexandra M., Moseley, James B., Dogic, Zvonimir, Grigorieff, Nikolaus, Gundersen, Gregg G., Goode, Bruce L.   +7 more
semanticscholar   +4 more sources

Regulated Binding of Adenomatous Polyposis Coli Protein to Actin [PDF]

Journal of Biological Chemistry, 2007
Adenomatous polyposis coli (APC) protein is a large tumor suppressor that is truncated in most colorectal cancers. The carboxyl-terminal third of APC protein mediates direct interactions with microtubules and the microtubule plus-end tracking protein EB1.
James B, Moseley, Francesca, Bartolini, Kyoko, Okada, Ying, Wen, Gregg G, Gundersen, Bruce L, Goode   +5 more
openaire   +3 more sources

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells [PDF]

Journal of Cell Biology, 2002
Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to its role in regulating β-catenin levels in the Wnt signaling pathway, the APC protein is ...
M. Mogensen, J. Tucker, J. Mackie, A. Prescott, I. Näthke   +4 more
semanticscholar   +2 more sources

Immunopurification of adenomatous polyposis coli (APC) proteins [PDF]

BMC Research Notes, 2013
AbstractBackgroundTheadenomatous polyposis coli(APC) tumour suppressor gene encodes a 2843 residue (310 kDa) protein. APC is a multifunctional protein involved in the regulation of β-catenin/Wnt signalling, cytoskeletal dynamics and cell adhesion.APCmutations occur in most colorectal cancers and typically result in truncation of the C-terminal half of ...
Elliott, KL, Catimel, B, Church, NL, Coates, JL, Burgess, AW, Layton, MJ, Faux, MC   +6 more
openaire   +5 more sources

Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein [PDF]

Proceedings of the National Academy of Sciences, 1997
Mutation of the adenomatous polyposis coli ( APC ) gene is an early step in the initiation of colon cancer. Because the distribution pattern of a protein within the cell can provide important clues as to function, we have used a combination of immunofluorescence microscopy and biochemical fractionation to determine ...
K L, Neufeld, R L, White
openaire   +3 more sources

Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein [PDF]

Molecular and Cellular Biology, 2001
Loss of functional adenomatous polyposis coli protein (APC) leads to uncontrolled proliferation of colonic epithelial cells, as evidenced by polyp formation, a prelude to carcinogenesis. As a tumor suppressor, APC targets the oncogene beta-catenin for proteasome-mediated cytoplasmic degradation.
F, Zhang, R L, White, K L, Neufeld
openaire   +3 more sources

Neurite outgrowth involves adenomatous polyposis coli protein and β-catenin [PDF]

Journal of Cell Science, 2005
Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites. The mechanisms underlying neurite formation are poorly understood. A candidate protein for controlling neurite extension is the adenomatous polyposis coli (APC) protein, which regulates membrane extensions, microtubules and β-
Violet, Votin, W James, Nelson, Angela I M, Barth   +2 more
openaire   +3 more sources

Adenomatous Polyposis Coli Associates with the Microtubule-Destabilizing Protein XMCAK [PDF]

Current Biology, 2004
During cell division, the proper formation of a bipolar spindle and its function to segregate chromosomes requires precise coordination of microtubule-stabilizing and destabilizing activities. Globally destabilized, dynamic microtubules radiating from duplicated centrosomes are locally regulated by chromosomes.
Banks, Jennifer D., Heald, Rebecca
openaire   +3 more sources

The Threshold Level of Adenomatous Polyposis Coli Protein for Mouse Intestinal Tumorigenesis [PDF]

Cancer Research, 2005
Abstract The adenomatous polyposis coli (APC) gene, whose mutations are responsible for familial adenomatous polyposis, is a major negative controller of the Wnt/β-catenin pathway. To investigate the dose-dependent effects of APC protein in suppressing intestinal tumorigenesis, we constructed mutant mice carrying hypomorphic Apc alleles ...
Qin, Li, Tomo-O, Ishikawa, Masanobu, Oshima, Makoto M, Taketo   +3 more
openaire   +3 more sources

The adenomatous polyposis coli protein. [PDF]

Molecular Pathology, 1999
Mutations in the adenomatous polyposis coli (APC) gene are associated with most colorectal cancers. The APC protein has been implicated in many aspects of tumour development. This article will discuss recent data suggesting that APC may have multiple functions in the cell.
I. Näthke
openaire   +3 more sources