Results 31 to 40 of about 194,615 (302)

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus-ends and is involved in establishing parallel arrays of microtubule bundles in highly polarised epithelial cells [PDF]

, 2002
Loss of full-length adenomatous polyposis coli (APC) protein correlates with the development of colon cancers in familial and sporadic cases. In addition to its role in regulating ß-catenin levels in the Wnt signaling pathway, the APC protein is ...
John B. Mackie, Mackie, JB, Nathke, Inke S.; id_orcid, Prescott, AR, Nathke, IS, Mogensen, MM, Mette M. Mogensen, Prescott, Alan R.; id_orcid, Mackie, John B., Tucker, John B., Inke S. Näthke, Näthke, Inke S., John B. Tucker, Mogensen, Mette M., Prescott, Alan R., Alan R. Prescott, Tucker, John Barry   +16 more
core   +1 more source

Recurrent APC gene mutations in Polish FAP families [PDF]

Hereditary Cancer in Clinical Practice, 2007
The molecular diagnostics of genetically conditioned disorders is based on the identification of the mutations in the predisposing genes. Hereditary cancer disorders of the gastrointestinal tracts are caused by mutations of the tumour suppressor genes or the DNA repair genes. Occurrence of recurrent mutation allows improvement of molecular diagnostics.
Pławski Andrzej, Podralska Marta, Słomski Ryszard   +2 more
openaire   +3 more sources

lemmingA encodes the Apc11 subunit of the APC/C in Drosophila melanogaster that forms a ternary complex with the E2-C type ubiquitin conjugating enzyme, Vihar and Morula/Apc2 [PDF]

, 2012
Background: Ubiquitin-dependent protein degradation is a critical step in key cell cycle events, such as metaphase-anaphase transition and mitotic exit.
Udvardy Andor, Deák Péter, Imre Boros, Nagy Olga, Olga Nagy, Margit Pál, Deak, Peter, Boros, Imre, Shirras Alan D, Alan D Shirras, Péter Deák, Nagy, Olga, Pál Margit, Shirras, Alan D., Andor Udvardy, Pal, Margit, Udvardy, Andor, Shirras Christine AM, Boros Imre, Christine AM Shirras, Shirras, Christine A. M.   +20 more
core   +1 more source

APC gene expression analysis.

, 2022
(a) Expression of the APC gene in various tissues. (b) Specificity expression of APC in RNA cancers. (c) Distribution of APC in cancer cells. (d) Specificity expression of APC in RNA single cells.
Xiaolong Tang (442900), Yinci Zhang (5417780), Amin Li (1960315), Xinkuang Liu (5417789)   +3 more
core   +1 more source

An APC Mutation in a Large Chinese Kindred With Familial Adenomatous Polyposis Was Identified Using Both Next Generation Sequencing and Simple STR Marker Haplotypes

Frontiers in Genetics, 2020
BackgroundFamilial adenomatous polyposis (FAP) is an autosomal dominant disorder characterized primarily by the development of numerous adenomatous polyps in the colon and a high risk for colorectal cancer.
Qitao Zhan, Liya Wang, Xiangrong Xu, Yan Sun, Lejun Li, Xuchen Qi, Feng Chen, Xiaoming Wei, Michael L. Raff, Ping Yu, Fan Jin   +10 more
doaj   +1 more source

Mutations of the APC Gene in Human Sporadic Colorectal Cancers [PDF]

Scandinavian Journal of Gastroenterology, 2002
Mutations of the APC gene are reported to occur frequently in sporadic colorectal adenomas and adenocarcinomas. We studied APC gene mutations in cases of human sporadic colorectal cancer in order to evaluate their correlation with pathologic characteristics and clinical prognosis.Most of the mutations of the APC gene (95%) are nonsense or frame shift ...
De Filippo, C, Luceri, C, Caderni, G, Pacini, M, Messerini, L, Biggeri, A, Mini, E, Tonelli, F, Cianchi, F, Dolara, P   +9 more
openaire   +5 more sources

Kaiso-deficient mice show resistance to intestinal cancer [PDF]

, 2006
Kaiso is a BTB domain protein that associates with the signaling molecule p120-catenin and binds to the methylated sequence mCGmCG or the nonmethylated sequence CTGCNA to modulate transcription.
Hendrich, B, Clarke, Alan Richard, Melnick, A, Sansom, Owen, Prokhortchouk, Anna, Clarke, A, Selfridge, Jim, Mariadason, JM, Caballero, Isabel M., Melnick, Ari, Sansom, O, Bird, Adrian, Caballero, Isabel M, Aithozhina, D, Mariadason, John M., Salozhin, Sergey, Augenlicht, Leonard H, Augenlicht, LH, Cerchietti, L, Meng, FG, Bird, A, Mariadason, John M, Cerchietti, Leandro, Selfridge, J, Clarke, Alan, Sansom, Owen J., Prokhortchouk, E, Hendrich, Brian, Prokhortchouk, A, Prokhortchouk, Egor, Caballero, IM, Aithozhina, Dana, Bird, Adrian; id_orcid, Augenlicht, Leonard H., Salozhin, S, Meng, Fan Guo   +35 more
core   +1 more source

An In-Depth Analysis of Colorectal Cancer in Erbil: Demographic Factors, Regional Disparities, Treatment Approaches and Genetic Studies [PDF]

Middle East Journal of Cancer
Backgroud: This study explores sex, age, histological subtype, cancer stages, treatment methods and genetic studies (mutation and expression) of Adenomatous Polyposis Coli (APC), Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), Tumor Protein 53 (TP53 ...
Basak Barzngy, Bestoon Hasan, Zjwan Housein, Khder Rasul, Abbas Salihi   +4 more
doaj   +1 more source

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. [PDF]

PLoS Genetics, 2009
Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of extra ...
Claudia Gaspar, Patrick Franken, Lia Molenaar, Cor Breukel, Martin van der Valk, Ron Smits, Riccardo Fodde   +6 more
doaj   +1 more source

Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

Human Genomics, 2011
The development and progression of colorectal cancer (CRC) is a multi-step process, and the Wnt pathways with its two molecular gladiators adenomatous polyposis coli (APC) and β-catenin plays an important role in transforming a normal tissue into a ...
Sameer A, Shah Zaffar A, Abdullah Safiya, Chowdri Nissar A, Siddiqi Mushtaq A   +4 more
doaj   +1 more source