Results 41 to 50 of about 7,566,127 (187)

Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

Human Genomics, 2011
The development and progression of colorectal cancer (CRC) is a multi-step process, and the Wnt pathways with its two molecular gladiators adenomatous polyposis coli (APC) and β-catenin plays an important role in transforming a normal tissue into a ...
Sameer A, Shah Zaffar A, Abdullah Safiya, Chowdri Nissar A, Siddiqi Mushtaq A   +4 more
doaj   +1 more source

Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers

Scientific Reports, 2021
The tumor suppressor gene adenomatous polyposis coli (APC) is the initiating mutation in approximately 80% of all colorectal cancers (CRC), underscoring the importance of aberrant regulation of intracellular WNT signaling in CRC development.
Adam Grant, Rosa M. Xicola, Vivian Nguyen, James Lim, Curtis Thorne, Bodour Salhia, Xavier Llor, Nathan Ellis, Megha Padi   +8 more
doaj   +1 more source

Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer

Frontiers in Oncology, 2022
BackgroundMutations in the tumor suppressor gene Adenomatous Polyposis Coli (APC) are found in 80% of sporadic colorectal cancer (CRC) tumors and are also responsible for the inherited form of CRC, Familial adenomatous polyposis (FAP).MethodsTo identify ...
Hannah Shailes, Wai Yiu Tse, Marta O. Freitas, Andrew Silver, Sarah A. Martin   +4 more
doaj   +1 more source

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

Genomics Data, 2016
The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in about 80% of colorectal cancers (CRC) Brannon et al. (2014) [1]. APC is a large multifunctional protein that regulates many biological functions including Wnt signalling (through ...
Lauren E. King, Christopher G. Love, Oliver M. Sieber, Maree C. Faux, Antony W. Burgess   +4 more
doaj   +1 more source

Expression Profiles in Stage II Colon Cancer According to APC Gene Status.

Translational Oncology, 2012
Colorectal cancer is one of the most common cancers in the world. Histoclinical staging is efficient, but combination with molecular markers may improve the classification of stage II cancers.
D. Birnbaum, S. Laibe, A. Ferrari, A. Lagarde, A. Fabre, G. Monges, D. Birnbaum, S. Olschwang   +7 more
semanticscholar   +1 more source

Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients

BMC Cancer, 2005
Background Familial Adenomatous Polyposis (FAP) is caused by germline mutations in the APC (Adenomatous Polyposis Coli) gene. The vast majority of APC mutations are point mutations or small insertions / deletions which lead to truncated protein products.
Danielidis Ioannis, Triantafillidis John K, Petropoulos Konstantinos, Koliopanos Alexander, Psychias Aristidis, Velissariou Voula, Dauwerse Hans, Apessos Angela, Mihalatos Markos, Fountzilas George, Agnantis Niki J, Nasioulas Georgios   +11 more
doaj   +1 more source

APC and MUTYH Analysis in FAP Patients: A Novel Mutation in APC Gene and Genotype-Phenotype Correlation [PDF]

Genes, 2018
APC and MUTYH genes are mutated in 70–90% and 10–30% of familial adenomatous polyposis cases (FAP) respectively. An association between mutation localization and FAP clinical phenotype is reported. The aims of this study were to determine APC and MUTYH mutational status in a small cohort of FAP patients and to evaluate the genotype-phenotype ...
D'Elia G., Caliendo G., Casamassimi A., Cioffi M., Molinari A. M., Vietri M. T.   +5 more
openaire   +2 more sources

Mutational spectrum of APC and genotype-phenotype correlations in Greek FAP patients

BMC Cancer, 2010
Background Familial adenomatous polyposis, an autosomal dominant inherited disease caused by germline mutations within the APC gene, is characterized by early onset colorectal cancer as a consequence of the intrinsic phenotypic feature of multiple ...
Fountzilas George, Sandaltzopoulos Raphael, Thodi Georgia, Fostira Florentia, Yannoukakos Drakoulis   +4 more
doaj   +1 more source

Familial Adenomatous Polyposis: An Uncommon Autosomal Genetic Condition [PDF]

Journal of Clinical and Diagnostic Research
A 40-year-old man presented to the Department of Emergency Medicine with severe pain in abdomen which was present for the past two days. He experienced three episodes of vomiting and two episodes of diarrhoea which was greenish in colour without any ...
Simran Khan, Shreya Giri, Suhit Naseri
doaj   +1 more source

Risk Assessment in Hereditary Colorectal Cancer Family by Using APC and MSH2 mRNA Gene Expression and Bayesian Analysis

Indonesian Biomedical Journal, 2020
BACKGROUND: Some of colorectal cancers (CRCs) are familial, however, heterozygote relatives have approximately 80% lifetime risk of cancer. Risk assessment of CRC’s family could be calculated by direct measurement of mRNA gene expression and Bayesian ...
Tjahjadi Robert Tedjasaputra, Mochammad Hatta, Muhammad Nasrum Massi, Rosdiana Natzir, Ilhamjaya Patellongi, Marcellus Simadibrata, Ibrahim Labeda, Rina Masadah, Muhammad Luthfi Parewangi, Prihantono Prihantono, Andi Asadul Islam, Agussalim Bukhari, Budu Budu, Rinda Nariswati   +13 more
doaj   +1 more source