Results 41 to 50 of about 194,615 (302)

Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers

Scientific Reports, 2021
The tumor suppressor gene adenomatous polyposis coli (APC) is the initiating mutation in approximately 80% of all colorectal cancers (CRC), underscoring the importance of aberrant regulation of intracellular WNT signaling in CRC development.
Adam Grant, Rosa M. Xicola, Vivian Nguyen, James Lim, Curtis Thorne, Bodour Salhia, Xavier Llor, Nathan Ellis, Megha Padi   +8 more
doaj   +1 more source

Mutations in APC, CTNNBI and K-ras genes and expression of hMLHI in sporadic colorectal carcinomas from the Netherlands Cohort Study [PDF]

, 2005
22.08.14 KB.
de Goeij, AFPM, de Bruïne Adriaan P, Luchtenborg, M, Saritas A Merdan, van Muijen, Goos NP, Saritas, AM, Weijenberg, MP, van Muijen, GNP, Saritas, A.M., Weijenberg, Matty P., Piet A van den Brandt, Roemen, GMJM, Adriaan P de Bruïne, de Goeij, Anton F P M, Wark, P.A., de Goeij Anton FPM, van Muijen, G.N.P., de Bruine, AP, de Bruine, A.P., Anton FPM de Goeij, de Bruïne, Adriaan P., Matty P Weijenberg, Lüchtenborg, Margreet, Margreet Lüchtenborg, van Muijen Goos NP, Roemen, G.M., A Merdan Saritas, Roemen, Guido M J M, Brandt, P.A. van den, Saritas, A. Merdan, Wark, PA, Wark Petra A, Muijen, G.N.P. van, Saritas, A Merdan, van den Brandt, Piet A, Weijenberg Matty P, Wark, Petra A.; id_orcid, van den Brandt, PA, Goos NP van Muijen, Weijenberg, Matty P, Roemen, G.M.J.M., van den Brandt, Piet A., de Bruïne, Adriaan P, van den Brandt Piet A, Guido MJM Roemen, de Goeij, Anton FPM, Lüchtenborg Margreet, Merdan Saritas, M., Bruine, A.P. de, van den Brandt, P.A., Luchtenborg, M., Goeij, A.F. de, Weijenberg, M.P., Wark, Petra A, Roemen Guido MJM, Roemen, Guido MJM, Petra A Wark, de Goeij, A.F., van Muijen, Goos N P   +58 more
core   +1 more source

Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer

Frontiers in Oncology, 2022
BackgroundMutations in the tumor suppressor gene Adenomatous Polyposis Coli (APC) are found in 80% of sporadic colorectal cancer (CRC) tumors and are also responsible for the inherited form of CRC, Familial adenomatous polyposis (FAP).MethodsTo identify ...
Hannah Shailes, Wai Yiu Tse, Marta O. Freitas, Andrew Silver, Sarah A. Martin   +4 more
doaj   +1 more source

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

Genomics Data, 2016
The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in about 80% of colorectal cancers (CRC) Brannon et al. (2014) [1]. APC is a large multifunctional protein that regulates many biological functions including Wnt signalling (through ...
Lauren E. King, Christopher G. Love, Oliver M. Sieber, Maree C. Faux, Antony W. Burgess   +4 more
doaj   +1 more source

APC and MUTYH Analysis in FAP Patients: A Novel Mutation in APC Gene and Genotype-Phenotype Correlation [PDF]

Genes, 2018
APC and MUTYH genes are mutated in 70–90% and 10–30% of familial adenomatous polyposis cases (FAP) respectively. An association between mutation localization and FAP clinical phenotype is reported. The aims of this study were to determine APC and MUTYH mutational status in a small cohort of FAP patients and to evaluate the genotype-phenotype ...
D'Elia G., Caliendo G., Casamassimi A., Cioffi M., Molinari A. M., Vietri M. T.   +5 more
openaire   +2 more sources

RP1 is a phosphorylation target of CK2 and is involved in cell adhesion [PDF]

, 2013
RP1 (synonym: MAPRE2, EB2) is a member of the microtubule binding EB1 protein family, which interacts with APC, a key regulatory molecule in the Wnt signalling pathway.
Renner, Christoph, Frank Stenner, Kleber Sascha, Göttig Stephan, Andreas Wadle (24358), Christoph Renner, Frank Stenner (24360), Alexander Knuth, Axel Mischo, Er Knuth, Stefan Bauer (24356), Zweifel, Martin, Michael Faust, Stephan Göttig (430017), Bauer, Stefan, Andreas Wadle, Faust Michael, Sascha Kleber (24359), Knuth, Alexander, Martin Zweifel, Martin Zweifel (430020), Heike Liewen, Mischo Axel, Stephan Göttig, Michael Faust (331617), Christoph Renner (24366), Markuly Norbert, Zweifel Martin, Stenner Frank, Wadle, Andreas, Kleber, Sascha, Markuly, Norbert, Axel Mischo (430019), Norbert Markuly, Reinhard Henschler (369547), Wadle Andreas, Norbert Markuly (430018), Liewen Heike, Henschler Reinhard, Alexander Knuth (11104), Heike Liewen (430016), Göttig, Stephan, Stenner, Frank, Sascha Kleber, Bauer Stefan, Renner Christoph, Reinhard Henschler, Liewen, Heike, Faust, Michael, Mischo, Axel, Stefan Bauer, Henschler, Reinhard, Knuth Alexander   +52 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Càncer colorectal hereditari: Aplicacions diagnòstiques de l'estudi de la dosi dels gens APC, MLH1 i MSH2 [PDF]

, 2009
[cat] Les síndromes de càncer colorectal (CCR) hereditari representen entre un 3% i un 5% de tots els casos de CCR i inclouen tots aquells individus amb un elevat grau d'agregació familiar.
Castellsagué Torrents, Ester
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men [PDF]

, 2005
Tumours in rodent and human colon share many histological and genetic features. To know if rodent models of colon carcinogenesis are good predictors of chemopreventive efficacy in humans, we made a meta-analysis of aspirin, beta-carotene, calcium, and ...
Denis E. Corpet, Pierre, Fabrice, Pierre, Fabrice H.F., Fabrice Pierre, Corpet, Denis E.   +4 more
core   +1 more source