Results 61 to 70 of about 194,615 (302)

Identification of mutation in 3'-end of exon 15 of APC gene in familial adenomatous polyposis patients

Fiyz̤, 2020
Background: Familial adenomatous polyposis (FAP) is a hereditary precancerous syndrome and is characterized by the manifestation of adenomatous polyps in the colon and rectum at an early age. Germline mutations of APC gene cause FAP.
Habibollahi H, Ranji N, Khazaei-Koohpar Z, Kamalifar HS   +3 more
doaj  

APC as a checkpoint gene: The beginning or the end? [PDF]

Gastroenterology, 2002
Colorectal cancer (CRC) is one of the most common malignancies in the United States. In 2002, it is estimated that 148,300 new cases of CRC will be diagnosed, resulting in approximately 56,600 deaths.1 The latter renders CRC the second leading cause of deaths from cancer in the United States. An individual’s life-time risk of developing CRC is 6%, with
openaire   +1 more source

Somatic Mutations of the APC Gene in Primary Breast Cancers [PDF]

The American Journal of Pathology, 2000
APC gene mutations play an important role in the initiation step of colorectal carcinogenesis in both familial adenomatous polyposis (FAP) patients and non-FAP patients. Although the APC gene is expressed in most tissues, including the lung, liver, kidney, and mammary gland, its somatic mutations have rarely been found in primary tumors affecting these
K, Furuuchi, M, Tada, H, Yamada, A, Kataoka, N, Furuuchi, J, Hamada, M, Takahashi, S, Todo, T, Moriuchi   +8 more
openaire   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

The Genomics of colorectal cancer: State of the art

, 2008
The concept of the adenoma-carcinoma sequence, as first espoused by Morson et al. whereby the development of colorectal cancer is dependent on a stepwise progression from adenomatous polyp to carcinoma is well documented.
Hodgson, SV, Hodgson, Shirley V, Beggs, AD, Beggs, Andrew D; id_orcid   +3 more
core   +1 more source

Evaluation Of APC Gene Expression And Methylation Pattern Following Bone Marrow-Derived Mesenchymal Stem Cell Differentiation Into Osteoblasts Category

پیاورد سلامت, 2016
Background and Aim: Different regulation processes have an effect on osteoblastic differentiation of mesenchymal stem cells (MSCs), and among them Wnt signaling pathway is particularly desirable. In Wnt signaling pathway, Adenomatous Polyposis Coli (APC)
Raja Al-Huthaifi, Ali Dehghanifard, Saeid Kaviani, Mehrdad Noruzinia, Samira Rezaei, Mehdi Azad, Maedeh Mashhadikhan, Saeid Solali   +7 more
doaj  

Adenomatous polyposis coli heterozygous knockout mice display hypoactivity and age-dependent working memory deficits

Frontiers in Behavioral Neuroscience, 2011
A tumor suppressor gene, Adenomatous polyposis coli (Apc), is expressed in the nervous system from embryonic to adulthood stage, and transmits the Wnt signaling pathway in which schizophrenia susceptibility genes, including T-cell factor 4 (TCF4) and ...
Hisatsugu eKoshimizu, Hisatsugu eKoshimizu, Yasuyuki eFukui, Keizo eTakao, Keizo eTakao, Koji eOhira, Koji eOhira, Koichi eTanda, Koichi eTanda, Kazuo eNakanishi, Keiko eToyama, Keiko eToyama, Masanobu eOshima, Makoto Mark Taketo, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa, Tsuyoshi eMiyakawa   +16 more
doaj   +1 more source

METTL3 promotes tumour development by decreasing APC expression mediated by APC mRNA N 6-methyladenosine-dependent YTHDF binding

Nature Communications, 2021
The epitranscriptomic regulation of adenomatous polyposis coli (APC) tumour suppressor gene in cancers is unclear. Here the authors show that N6-methyladenosine methylation writer METTL3 downregulates APC by recruiting YTHDF2 for APC mRNA degradation ...
Wei Wang, Fei Shao, Xueying Yang, Juhong Wang, Rongxuan Zhu, Yannan Yang, Gaoxiang Zhao, Dong Guo, Yingli Sun, Jie Wang, Qi Xue, Shugeng Gao, Yibo Gao, Jie He, Zhimin Lu   +14 more
doaj   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Association between the APC gene D1822V variant and the genetic susceptibility of colorectal cancer

, 2014
Adenomatous polyposis coli (APC) gene polymorphisms are believed to contribute to tumor susceptibility. However, the association between genetic variants (A/T) in the APC gene D1822V polymorphism and colorectal cancer (CRC) susceptibility remains unknown.
Yang, Qian, Li, Huachi, Ouyang, Gang, Fang, Xiping, Xie, Wei, Chen, Daping, Ma, Xiang, Feng, Maohui   +7 more
core   +1 more source