Results 81 to 90 of about 194,615 (302)
The association between multiple pilomatrixomas and APC gene mutations
, 2018 Dear Editor, Familial adenomatous polyposis is an autosomal dominant disorder caused by a germline mutation of the tumour suppressor gene adenomatous polyposis coli (APC) located on chromosome 5q22.2.
Rodins, Karl +5 more
core +1 more source
Chinese Medical Journal. Background:. Endometrial cancer (EC) is one of the most common gynecological cancers worldwide. High-order chromatin structure plays a critical role in regulating gene expression.
Yunfeng Song +8 more
doaj +1 more source
Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells. [PDF]
PLoS ONE, 2018 Mutations in the gene Adenomatous Polyposis Coli or APC appear in most sporadic cases of colorectal cancer and it is the most frequent mutation causing hereditary Familial Adenomatous Polyposis.
Cesar A Sommer +7 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano +11 more
wiley +1 more source
Genomic Instability of the APC Gene Found in Glioblastoma
Neurologia Croatica. Supplement, 2007 The etiology and pathogenesis of tumors of the central nervous system are still inadequately explained. This study analyses tumor suppressor gene— adenomatous polyposis coli (APC) in 28 patients with glioblastoma, the most aggressive form of glial tumors.
Pećina-Šlaus, Nives +2 more
openaire +3 more sources
Prediction and testing of biological networks underlying intestinal cancer. [PDF]
PLoS ONE, 2010 Colorectal cancer progresses through an accumulation of somatic mutations, some of which reside in so-called "driver" genes that provide a growth advantage to the tumor.
Vishal N Patel +5 more
doaj +1 more source
MYH Gene Status in Polish FAP Patients without APC Gene Mutations [PDF]
Hereditary Cancer in Clinical Practice, 2006 Familial Adenomatous Polyposis (FAP) is an inheritable predisposition for the occurrence of numerous polyps in the large intestine. In about 50% of all patients, the occurrence of the disease is conditioned by heterozygotic mutations of the APC gene. Screening for genetic factors in persons without mutations in the APC gene led to the identification of
Skrzypczak Marzena +6 more
openaire +3 more sources
Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles
Advanced Materials, EarlyView.This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen +19 more
wiley +1 more source
BMC Medical Genetics, 2009 Background Familial adenomatous polyposis (FAP) is an autosomal dominant-inherited colorectal cancer syndrome, caused by germline mutations in the APC gene.
Gómez-Fernández Nuria +11 more
doaj +1 more source
Advanced Materials, EarlyView.This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang +10 more
wiley +1 more source