Results 21 to 30 of about 190,398 (210)

An In-Depth Analysis of Colorectal Cancer in Erbil: Demographic Factors, Regional Disparities, Treatment Approaches and Genetic Studies [PDF]

Middle East Journal of Cancer
Backgroud: This study explores sex, age, histological subtype, cancer stages, treatment methods and genetic studies (mutation and expression) of Adenomatous Polyposis Coli (APC), Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS), Tumor Protein 53 (TP53 ...
Basak Barzngy, Bestoon Hasan, Zjwan Housein, Khder Rasul, Abbas Salihi   +4 more
doaj   +1 more source

A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis. [PDF]

PLoS Genetics, 2009
Germline mutations in the adenomatous polyposis coli (APC) gene are responsible for familial adenomatous polyposis (FAP), an autosomal dominant hereditary predisposition to the development of multiple colorectal adenomas and of a broad spectrum of extra ...
Claudia Gaspar, Patrick Franken, Lia Molenaar, Cor Breukel, Martin van der Valk, Ron Smits, Riccardo Fodde   +6 more
doaj   +1 more source

Analysis of molecular aberrations of Wnt pathway gladiators in colorectal cancer in the Kashmiri population

Human Genomics, 2011
The development and progression of colorectal cancer (CRC) is a multi-step process, and the Wnt pathways with its two molecular gladiators adenomatous polyposis coli (APC) and β-catenin plays an important role in transforming a normal tissue into a ...
Sameer A, Shah Zaffar A, Abdullah Safiya, Chowdri Nissar A, Siddiqi Mushtaq A   +4 more
doaj   +1 more source

Molecular drivers of tumor progression in microsatellite stable APC mutation-negative colorectal cancers

Scientific Reports, 2021
The tumor suppressor gene adenomatous polyposis coli (APC) is the initiating mutation in approximately 80% of all colorectal cancers (CRC), underscoring the importance of aberrant regulation of intracellular WNT signaling in CRC development.
Adam Grant, Rosa M. Xicola, Vivian Nguyen, James Lim, Curtis Thorne, Bodour Salhia, Xavier Llor, Nathan Ellis, Megha Padi   +8 more
doaj   +1 more source

Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer

Frontiers in Oncology, 2022
BackgroundMutations in the tumor suppressor gene Adenomatous Polyposis Coli (APC) are found in 80% of sporadic colorectal cancer (CRC) tumors and are also responsible for the inherited form of CRC, Familial adenomatous polyposis (FAP).MethodsTo identify ...
Hannah Shailes, Wai Yiu Tse, Marta O. Freitas, Andrew Silver, Sarah A. Martin   +4 more
doaj   +1 more source

Differential RNA-seq analysis comparing APC-defective and APC-restored SW480 colorectal cancer cells

Genomics Data, 2016
The adenomatous polyposis coli (APC) tumour suppressor gene is mutated in about 80% of colorectal cancers (CRC) Brannon et al. (2014) [1]. APC is a large multifunctional protein that regulates many biological functions including Wnt signalling (through ...
Lauren E. King, Christopher G. Love, Oliver M. Sieber, Maree C. Faux, Antony W. Burgess   +4 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Rare mutations predisposing to familial adenomatous polyposis in Greek FAP patients

BMC Cancer, 2005
Background Familial Adenomatous Polyposis (FAP) is caused by germline mutations in the APC (Adenomatous Polyposis Coli) gene. The vast majority of APC mutations are point mutations or small insertions / deletions which lead to truncated protein products.
Danielidis Ioannis, Triantafillidis John K, Petropoulos Konstantinos, Koliopanos Alexander, Psychias Aristidis, Velissariou Voula, Dauwerse Hans, Apessos Angela, Mihalatos Markos, Fountzilas George, Agnantis Niki J, Nasioulas Georgios   +11 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source