Results 21 to 30 of about 194,615 (302)

APC protein immunoexpression in colorectal adenoma and adenocarcinoma

Journal of Coloproctology, 2013
Background: activation of the Wnt pathway by mutated APC gene is considered the initial event in colorectal carcinogenesis. The identification of these mutations can improve the specific treatment of the adenocarcinoma.
Vivian Sati Oba Bourroul, Guilherme Muniz Bourroul, Giovanna Canato Toloi, Rogério Tadeu Palma, Celina Tizuko Fujiyama Oshima, Thiago Simão Gomes, Sílvia Saiuli Miki Ihara, Jaques Waisberg   +7 more
doaj   +1 more source

Pedigree investigation and predictive gene testing of the APC gene for colonic adenomatous polyposis

结直肠肛门外科, 2023
[Objectives] Pedigree investigation and predictive genetic testing for colonic adenomatous polyposis (CAP) has not been systematically conducted in China, and its practical value remains unreported.
Fang Ruihua, Wang Zhaoming, Qiu Xiaoqian, Zhu Weiye, Ge Sai, Wang Chenglong, Qiu Geng, Gao Xianhua, Xu Xiaodong, Xing Junjie, Wang Hao, Zhang Wei, Yu Enda, Zhao Ziye   +13 more
doaj   +1 more source

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, Burkhard, Göke, B., Kolligs, Frank T, Bommer, Guido, Kolligs, F. T.   +5 more
core   +1 more source

APC Gene Mutations in Human Prostate Cancer [PDF]

Japanese Journal of Clinical Oncology, 1996
Prostate cancer is the most common cancer in aged men. Although ras and p53 gene mutations have been detected in some prostate cancers, the major genetic alterations involved in its carcinogenesis are not well understood. Mutation of the APC gene is responsible for colorectal tumors in which ras and p53 mutations are also often involved. Using PCR-SSCP
M, Watanabe, H, Kakiuchi, H, Kato, T, Shiraishi, R, Yatani, T, Sugimura, M, Nagao   +6 more
openaire   +2 more sources

Genetic dissection of differential signaling threshold requirements for the Wnt/β-catenin pathway in vivo [PDF]

, 2010
Contributions of null and hypomorphic alleles of Apc in mice produce both developmental and pathophysiological phenotypes. To ascribe the resulting genotype-to-phenotype relationship unambiguously to the Wnt/beta-catenin pathway, we challenged the allele
Newton, Ian P., Jarnicki, Andrew G., Nathke, Inke S.; id_orcid, Sansom, Owen, Nathke, I., Samuel, M., Suzuki, Hiromu, Tosh, David, Abud, H E, Newton, IP, Huelsken, J, Stacker, SA, Samuel, M S, Buchert, M, Ernst, M., Stacker, Steven, Stacker, S., Dimitris Athineos, Alan R Clarke, Newton Ian P., Helen E. Abud, Heath, JK, Abud Helen E., Clarke Alan R., Suzuki, H., Faux, Maree, Newton, I., Jarnicki, A.G., Meniel, VS, Michael Buchert, Ernst, Matthias, Sansom, Owen J., Sansom Owen J., Meniel, Valerie, Clarke, Alan R., Burke, Z D, Ian P Newton, Inke S Näthke, David Tosh, Näthke, I.S., Winbanks, Catherine, Ian P. Newton, Sansom, O J, Burke, Z., Samuel Michael S., Samuel, M.S., Näthke Inke S., Inke S. Näthke, Jarnicki, A G, Abud, H.E., Tosh, D, Burke, ZD, Catherine E Winbanks, Samuel, Michael S., Heath Joan K., Andrew G Jarnicki, Nusse, R., Jarnicki, Andrew, Meniel, V.S., Abud, H., Samuel, MS, Joan K Heath, Winbanks, C E, Clarke, A R, Winbanks, C.E., Suzuki Hiromu, Winbanks Catherine E., Clarke, Alan Richard, Clarke, A.R., Joerg Huelsken, Stacker, Steven A., Helen E Abud, Alan R. Clarke, Buchert, M., Owen J. Sansom, Abud, HE, Joan K. Heath, Faux Maree C., Jarnicki, AG, Owen J Sansom, Athineos Dimitris, Suzuki, H, Faux, M., Winbanks, C., Matthias Ernst, Huelsken Joerg, Athineos, D, Sansom, O.J., Burke, Zoe D., Meniel Valerie S., Huelsken, J., Tosh David, Newton, I.P., Samuel, Michael, Athineos, Dimitris, Ernst Matthias, Jarnicki Andrew G., Zoe D Burke, Stacker, S.A., Stacker, S A, Clarke, Alan, Buchert, Michael, Abud, Helen E., Michael S. Samuel, Jarnicki, A., Steven A Stacker, Meniel, Valerie S., Faux, M C, Athineos, D., Meniel, V., Ernst, M, Michael S Samuel, Heath, Joan K., Nathke, I S, Sansom, OJ, Newton, Ian, Tosh, D., Valerie S. Meniel, Clarke, AR, Newton, I P, Näthke, Inke S., Meniel, V S, Valerie S Meniel, Buchert Michael, Newton, Ian P, Heath, Joan, Maree C Faux, Näthke, IS, Burke, Z.D., Heath, J., Maree C. Faux, Faux, Maree C., Winbanks, Catherine E., Heath, J K, Faux, M.C., Abud, Helen, Catherine E. Winbanks, Faux, MC, Sansom, O., Burke, Zoe, Andrew G. Jarnicki, Steven A. Stacker, Hiromu Suzuki, Zoe D. Burke, Huelsken, Joerg, Heath, J.K., Stacker Steven A., Burke Zoe D., Winbanks, CE, Nathke, Inke, Clarke, A.   +150 more
core   +1 more source

Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium. [PDF]

PLoS Genetics, 2015
Adenomatous polyposis coli (APC) inactivating mutations are present in most human colorectal cancers and some other cancers. The APC protein regulates the β-catenin protein pool that functions as a co-activator of T cell factor (TCF)-regulated ...
Ying Feng, Naoya Sakamoto, Rong Wu, Jie-Yu Liu, Alexandra Wiese, Maranne E Green, Megan Green, Aytekin Akyol, Badal C Roy, Yali Zhai, Kathleen R Cho, Eric R Fearon   +11 more
doaj   +1 more source

Somatic Mutation Rate of the APC Gene [PDF]

Japanese Journal of Clinical Oncology, 2001
Somatic inactivation of the wild-type APC gene is involved in the development of adenoma of familial adenomatous polyposis. This situation is also true in sporadic adenomas. It is of biological interest to know the somatic mutation rate of the APC gene.The number of stem cells of the colon (N) and somatic mutation rate of the APC gene in a stem cell in
openaire   +2 more sources

Hereditary colorectal cancer : assessment of genotype-phenotype correlations and analysis of rare susceptibility genes in familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC) [PDF]

, 2008
Each year 3500 people in Switzerland are diagnosed with colorectal cancer. Approximately 20 percent of all affected patients have two or more first or second-degree relatives with colorectal cancer (at-risk family members). About five percent of these
Necker, Judith
core   +1 more source

To Identify Adenomatous Polyposis Coli Gene Mutation as a Predictive Marker of Endometrial Cancer Immunotherapy

Frontiers in Cell and Developmental Biology, 2022
The adenomatous polyposis coli (APC) gene is the chromatin-remodeling-related gene and a typical tumor suppressor. Patients with a high expression of programmed death-ligand 1 (PD-L1) or a high level of tumor mutational burden (TMB) may benefit from ...
Yunfeng Song, Jian Huang, Kai Wang, Yiran Li, Yiran Li   +4 more
doaj   +1 more source

APC Gene Testing for Familial Adenomatosis Polyposis [PDF]

JAMA, 2012
While genomics is destined to revolutionize clinical medicine, to date its beneficial effects have been somewhat muted. The promise and perils of genomics are emblemized by one of its flagship applications, namely the diagnosis of familial adenomatosis polyposis (FAP).
Hemant K, Roy, Janardan D, Khandekar
openaire   +2 more sources