Results 191 to 200 of about 489,446 (226)
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Adenosine and adenosine receptors in colorectal cancer
International Immunopharmacology, 2020CD39 (nucleoside triphosphate diphosphohydrolase) and Ecto-5-nucleotidase (CD73) have been recognized as important factors mediating various pathological and physiological responses in the tumor microenvironment. Elevated expression of CD73 and CD39 is correlated with the over-production of adenosine in the tumor region.
A.V. Sevbitov +7 more
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American Journal of Physiology-Heart and Circulatory Physiology, 1992
Dipyridamole is proposed to increase coronary blood flow (CBF) by inhibition of adenosine uptake into cells, resulting in an increase in interstitial fluid (ISF) adenosine and an adenosine-mediated vasodilation. The purpose of this study was to determine the changes in CBF and ISF adenosine, inosine, and hypoxanthine during dipyridamole infusion in ...
D. G. L. Van Wylen +2 more
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Dipyridamole is proposed to increase coronary blood flow (CBF) by inhibition of adenosine uptake into cells, resulting in an increase in interstitial fluid (ISF) adenosine and an adenosine-mediated vasodilation. The purpose of this study was to determine the changes in CBF and ISF adenosine, inosine, and hypoxanthine during dipyridamole infusion in ...
D. G. L. Van Wylen +2 more
openaire +3 more sources
Is adenosine deaminase involved in adenosine transport?
Medical Hypotheses, 1990The hypothesis that adenosine metabolizing enzymes may have a key role in the transport of adenosine is discussed. The enhancement of adenosine transport by inhibitors of adenosine deaminase (the enzyme which deaminates adenosine to inosine) and the ecto-localization of adenosine deaminase suggest a contribution of the enzyme in taking up nucleosides ...
Josep J. Centelles, Rafael Franco
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Sleep Medicine Reviews, 2002
Adenosine is directly linked to the energy metabolism of cells. In the central nervous system an increase in neuronal activity enhances energy consumption as well as extracellular adenosine concentrations. In most brain areas high extracellular adenosine concentrations, through A(1) adenosine receptors, decrease neuronal activity and thus the need for ...
Tarja Porkka-Heiskanen +3 more
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Adenosine is directly linked to the energy metabolism of cells. In the central nervous system an increase in neuronal activity enhances energy consumption as well as extracellular adenosine concentrations. In most brain areas high extracellular adenosine concentrations, through A(1) adenosine receptors, decrease neuronal activity and thus the need for ...
Tarja Porkka-Heiskanen +3 more
openaire +3 more sources
Cardioprotective actions of adenosine and adenosine analogs
1996Adenosine contributes to the physiological regulation of cardiovascular function and it clearly plays important roles under pathophysiological conditions. The nucleoside functions intracellularly as a major contributor to the general cellular economy and extracellularly as an important signalling molecule.
M. A. Cook, M. Karmazyn
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Science, 1991
The crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase complexed with a 20-amino acid substrate analog inhibitor has been solved and partially refined at 2.7 A resolution to an R factor of 0.212.
D. Knighton +6 more
semanticscholar +1 more source
The crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase complexed with a 20-amino acid substrate analog inhibitor has been solved and partially refined at 2.7 A resolution to an R factor of 0.212.
D. Knighton +6 more
semanticscholar +1 more source
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1990
Adenosine is a purine nucleoside present in every cell of the human body. It is released into the extracellular space under physiologic and pathophysiologic conditions characterized by increased oxygen demand: supply ratio. Adenosine can exert a wide spectrum of effects in various organs and tissues.
Amir Pelleg, R. Stephen Porter
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Adenosine is a purine nucleoside present in every cell of the human body. It is released into the extracellular space under physiologic and pathophysiologic conditions characterized by increased oxygen demand: supply ratio. Adenosine can exert a wide spectrum of effects in various organs and tissues.
Amir Pelleg, R. Stephen Porter
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Adenosine, adenosine A2A antagonists, and Parkinson's disease
Parkinsonism & Related Disorders, 2009Adenosine derived from the degradation of ATP/AMP functions as a signalling molecule in the nervous system through the occupation of A1, A2, and A3 adenosine receptors. Adenosine A(2A) receptors have a selective localization to the basal ganglia and specifically to the indirect output pathway, and as a consequence offer a unique opportunity to modulate
JENNER P +5 more
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ChemInform Abstract: Adenosine Derivatives as Agonists of Adenosine Receptors
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Palmarisa Franchetti +3 more
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2017
The classic endogenous somnogen adenosine promotes sleep via A1 and A2A receptors. In this chapter, we present an overview of the current knowledge regarding the regulation of adenosine levels, adenosine receptors, and available pharmacologic and genetic tools to manipulate the adenosine system. This is followed by a summary of current knowledge of the
Michael Lazarus +5 more
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The classic endogenous somnogen adenosine promotes sleep via A1 and A2A receptors. In this chapter, we present an overview of the current knowledge regarding the regulation of adenosine levels, adenosine receptors, and available pharmacologic and genetic tools to manipulate the adenosine system. This is followed by a summary of current knowledge of the
Michael Lazarus +5 more
openaire +3 more sources