Results 191 to 200 of about 892,163 (354)

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

Advanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan, Yinghao Hong, Xiangjun Ji, Jing Xiang, Jinxi Liu, Lixin Liang, Meng Ren, Wenhan Chen, Tengfei Xu, Zhijie Li, Tieliu Shi, Yong Jiang, Huaping Liang, Jinghua Liu   +13 more
wiley   +1 more source

A2AR Adenosine Signaling Suppresses Natural Killer Cell Maturation in the Tumor Microenvironment.

Cancer Research, 2018
A. Young, S. Ngiow, Yulong Gao, A. Patch, Deborah S. Barkauskas, M. Messaoudene, G. Lin, J. Coudert, Kimberley A Stannard, L. Zitvogel, M. Degli-Esposti, É. Vivier, N. Waddell, J. Linden, N. Huntington, F. Souza-Fonseca-Guimaraes, M. Smyth   +16 more
semanticscholar   +1 more source

The Study of Chinese Herbal Medicinal Prescription with Enzyme Inhibitory Activity. VI. The Study of Makyo-kanseki-to with Adenosine 3', 5'-Cyclic Monophosphate Phosphodiesterase

, 1992
Tamotsu NIKAIDO, Setsuko IIZUKA, Noriko OKADA, Takashi Kuge, Taichi OHMOTO   +4 more
openalex   +2 more sources

Microfilament‐Myosin II Regulates the Differentiation of Multinucleated Cysts into Oocytes and Influences Oocyte Developmental Potential in Mice

Advanced Science, EarlyView.
In this study, we provided new evidence identifying multinucleated cysts as precursors for oocyte differentiation. Within these cysts, organelles migrate and aggregate to form Balbiani body (B‐body) and establish early cellular polarity. Concurrently, excess nuclei are expelled, enabling cyst‐to‐oocyte differentiation. The microfilament‐myosin II plays
Rui Xu, Menghao Pan, Zhi Zheng, Yaju Tang, Yutong Yan, Sihai Lu, Sha Peng, Baohua Ma   +7 more
wiley   +1 more source

Long-term expression of human adenosine deaminase in vascular smooth muscle cells of rats: a model for gene therapy.

, 1992
Carmel M. Lynch, M M Clowes, William Osborne, A W Clowes, A. Dusty Miller   +4 more
openalex   +2 more sources

Time‐Dependent Therapeutic Effect of S‐Ketamine on PTSD Mediated by VTA‐OFC Dopaminergic Neurocircuit

Advanced Science, EarlyView.
This study reveals that early rather than late administration of S‐ketamine can ameliorate PTSD symptoms. This phenomenon is attributed to reversing the progressive inhibition of VTADA neurons and the function of VTADA‐OFC circuit following stress. Targeted stimulation of the OFC by TI‐NIBS to enhance DA release effectively extends the therapeutic time
Ye Wang, Lei Liu, Jinghao Wang, Jiannan Li, Huiming Li, Rui Wang, Hui Wang, Min Wang, Quanying Liu, Zhongmin Fan, Yunyun Zhang, Xinxin Zhang, Dan Wang, Sa Wang, Rou Xue, Jindong Mao, Min Cai, Pengfei Wei, Hailong Dong, Yumei Wu, Guangchao Zhao   +20 more
wiley   +1 more source

A protein binding assay for adenosine 3':5'-cyclic monophosphate.

Proceedings of the National Academy of Sciences of the United States of America, 1970
A. Gilman
semanticscholar   +1 more source

Coronary Vasospasm, an Unexpected Side Effect of Adenosine: A Case Report and Review of the Literature. [PDF]

Case Rep Cardiol
Jimidar N, Bringmans T, Saenen J, Van Craenenbroeck E.   +3 more
europepmc   +1 more source

Cinobufagin Directly Targets PDE4D to Disrupt Fibroblast–Dendritic Cell Crosstalk in Atopic Dermatitis

Advanced Science, EarlyView.
Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li, Dihui Xu, Chenyang Zhang, Chunxiu Xiao, Meng Yu, Jiaojiao Wang, Wenyuan Wu, Xiang Lv, Dongping Yuan, Liang Zhang, Min Hong, Jing Zhou, Yang Sun, Hongyue Ma, Yuyu Zhu   +14 more
wiley   +1 more source

Cancer immunotherapy by adenosinergic CD39 and CD73 as emerging immune checkpoints. [PDF]

Discov Oncol
Yin X, Yang Y, Liu S.
europepmc   +1 more source