Results 231 to 240 of about 869,856 (392)

Gasdermin D‐Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis

Advanced Science, EarlyView.
Gasdermin D (GSDMD) does not only reduce pancreatic enzyme synthesis but also induces pancreatic acinar cells to express mucin 1 (MUC1), which forms a barrier to prevent digestive enzyme‐mediated digestion. However, GSDMD can promote the secretion of inflammatory cytokines by macrophages and aggravate pancreatic histological injury by expanding ...
Chaoxu Liu, Ning Liang, Chen Wu, Zhaoyan Qiu, Qian Huang, Xiaolong Wei, Shurong Zhang, Shuanghong Lei, Tao Yang, Gang Wang, Qian Wang   +10 more
wiley   +1 more source

A DETAILED PROCEDURE FOR THE PREPARATION OF HIGHLY PURIFIED ADENOSINE TRIPHOSPHATE

, 1948
Alexander L. Dounce, Aser Rothstein, G. Beyer, R. Meier, Richard M. Freer   +4 more
openalex   +1 more source

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

Journal of Clinical Investigation, 2017
P. Beavis, M. Henderson, Lauren Giuffrida, J. Mills, K. Sek, R. Cross, A. Davenport, Liza B. John, Sherly Mardiana, C. Slaney, R. Johnstone, J. Trapani, J. Stagg, S. Loi, Lev M. Kats, D. Gyorki, M. Kershaw, P. Darcy   +17 more
semanticscholar   +1 more source

Epigenetic Regulation of DAPK1 and Netrin‐1 Drives Diabetic Encephalopathy

Advanced Science, EarlyView.
This study identifies a microRNA (miR)‐216a‐5p/death‐associated protein kinase 1 (DAPK1)/hepatocyte nuclear factor 1 homeobox A (HNF1A)/Netrin‐1 signaling axis in diabetic encephalopathy (DE). In leptin receptor‐deficient (db/db) and streptozotocin (STZ)‐induced diabetic mice, reduced miR‐216a‐5p increases DAPK1 expression, disrupting HNF1A binding to ...
Yang Zhou, Jia‐Xin Kou, Kai Zheng, Zi‐Xuan Guo, Hong‐Wei Fan, Wen‐Lian Li, Lu‐Lu Chu, Jing‐Wen Yin, Li‐Jie Liu, Zhi‐Gao Xiang, Feng Hu, Kai Shu, Ling‐Qiang Zhu, Dan Liu   +13 more
wiley   +1 more source

Multiplexing FSCV and iGluSnFR3 Sensors Reveals Adenosine Transiently Inhibits Stimulated Dopamine and Glutamate Release. [PDF]

J Neurochem
Shrestha K, Chang Y, Zhang Y, Venton BJ.
europepmc   +1 more source

THE EFFECTS OF TRIPHOSPHOPYRIDINE NUCLEOTIDE AND OF ADENOSINE TRIPHOSPHATE ON PIGEON LIVER OXALACETIC CARBOXYLASE

, 1947
Birgit Vennesland, E. Anthony Evans, Kurt I. Altman   +2 more
openalex   +1 more source

Adenosine and the Cardiovascular System

American Journal of Cardiovascular Drugs, 2019
A. Reiss, D. Grossfeld, L. Kasselman, Heather A. Renna, Nicholas A. Vernice, Wendy Drewes, Justin Konig, S. Carsons, J. Deleon   +8 more
semanticscholar   +1 more source

Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells

Advanced Science, EarlyView.
Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng, Jiayao Li, Wuke Wang, Dong Liang, Zhanwei Li, Cong Mao, Qingyang Li, Yu Zhang, Hao Chen, Jin Tang, Ping Hu, Qi Niu, Xingxu Huang, Bin Shen, Jun Zhang   +14 more
wiley   +1 more source

Adenosine deaminase in pleural effusion: Bridging diagnosis and the pathophysiology of inflammation. [PDF]

World J Clin Cases
Shi DD, Tian J, Ding J.
europepmc   +1 more source

THE CLEAVAGE OF ADENOSINE, CYTIDINE, AND XANTHOSINE BY LACTOBACILLUS PENTOSUS

, 1951
T.P. Wang, J. O. Lampen
openalex   +1 more source