Results 181 to 190 of about 1,637,170 (273)

METTL7B‐Mediated m6A Modification of PLEKHA4 Suppresses Ferroptosis via Reducing AURKA Ubiquitination to Promote Papillary Thyroid Cancer Progression

Cancer Medicine, Volume 15, Issue 11, November 2026.
In PTC cells, METTL7B stabilizes PLEKHA4 mRNA through m6A modification; upregulated PLEKHA4 binds KLHL12 and inhibits KLHL12‐mediated ubiquitination and degradation of AURKA, thereby stabilizing AURKA protein. Elevated AURKA suppresses ferroptosis by upregulating GPX4 and xCT while downregulating ACSL4, leading to ferroptosis resistance and enhanced ...
Wei Lin, Kunlin Wu, Jinshu Chen, Zhaomei Yu, Huihao Zhang, Xiangjin Chen   +5 more
wiley   +1 more source

Role of Adenosine A1 Receptor in Sleep Deprivation-Induced Neuroinflammation: Insights on Rapid Eye Movement Sleep and Fear Extinction Memory Recall in Rats. [PDF]

Cureus
Thondala B, Chauhan G, Pawar H, Ray K, Sharma M, Yadav N, Kumar S, Kishore K, Panjwani U.   +8 more
europepmc   +1 more source

Neuroprotective Effects of Adenosine A1 Receptor Signaling on Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Mice. [PDF]

Front Cell Neurosci, 2020
Zhang Y, Cao H, Qiu X, Xu D, Chen Y, Barnes GN, Tu Y, Gyabaah AT, Gharbal AHAA, Peng C, Cai J, Cai X.   +11 more
europepmc   +1 more source

Quinoxaline–Triazole Hybrids: Exploring the Impact of Substituent Architecture on Cytotoxic Potency and Receptor Interaction

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
A series of title compounds was synthesized, with 6e and 6k exhibiting the lowest IC50 values against MCF‐7, HeLa, and HepG2 cancer cell lines. Molecular docking and dynamics revealed strong binding to the adenosine A1 receptor (ΔG = –9.02 and –9.24 kcal/mol).
Bangar Reddy Vancha, Mandapalli Sreeshitha, Shaik Farheen Banu, Kamala Prasad Vasikarla, Satyanarayana Swamy Vyshnava, Mukhriddin Makhkamov, Parthiban Marimuthu, Jamoliddin Razzokov, Aminul Islam, Peddiahgari Vasu Govardhana Reddy   +9 more
wiley   +1 more source

Podocyte Density and Albuminuria in Aging Diabetic Ins2± Mice with or Without Adenosine A1 Receptor Signaling. [PDF]

Int J Nephrol Renovasc Dis, 2020
Faulhaber-Walter R, Jiang L, Mizel D, Zerfas PM, Kopp JB, Schnermann JB, Chen L, Schiffer M.   +7 more
europepmc   +1 more source

The Effect of Acute Beetroot Juice and Caffeine Supplementation on Specific Judo Performance During a Simulated Competition Day in Judo Athletes

European Journal of Sport Science, Volume 26, Issue 11, November 2026.
ABSTRACT Beetroot juice (BJ) and caffeine (CAF) are well‐established ergogenic aids for exercise performance. However, little is known about their efficacy and interaction within the specific context of a judo competition day. This study investigated the acute effects of BJ, CAF, and their combination (BJCAF) on judo‐specific performance across a ...
Sefer Karabağ, Heidar Sajedi, Onur Güler, Vahdet Alaeddinoğlu, Ergün Çakır, Davar Khodadadi, Selahattin Akpınar   +6 more
wiley   +1 more source

Two-Step Ligand-Directed Covalent Fluorescent Labeling of the Adenosine A₁-Receptor That Maintains Its Orthosteric Binding Site's Availability to Bind Ligands. [PDF]

J Med Chem
Lin CY, Platt S, Goulding J, Briddon SJ, Kindon ND, Harwood CR, Lai CW, Kellam B, Hill SJ.   +8 more
europepmc   +1 more source

Positive allosteric mechanisms of adenosine A₁ receptor-mediated analgesia. [PDF]

Nature, 2021
Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, White PJ, Scammells P, May LT, Sexton PM, Danev R, Miao Y, Glukhova A, Imlach WL, Christopoulos A.   +23 more
europepmc   +1 more source

Beneficial Role of Natural Polyphenols Against Epilepsy: Greasing the Wheels of Pharmacotherapy Research for Epilepsy

Food Frontiers, Volume 7, Issue 6, November 2026.
ABSTRACT Epilepsy is the most disabling neurological disease that affects all economic classes, age groups, regions, and races. Although many antiseizure drugs are approved for epilepsy treatment, they fail to work in about 30%–40% of patients. Thus, there is a great need to identify better pharmacological agents to treat epilepsy.
Janakiraman Pillai Udaiyappan, Rengasamy Balakrishnan, Manivasagam Muthukumaran Tamilarasan, Subasri Pandian   +3 more
wiley   +1 more source

The Signaling Pathways Involved in the Anticonvulsive Effects of the Adenosine A₁ Receptor. [PDF]

Int J Mol Sci, 2020
Spanoghe J, Larsen LE, Craey E, Manzella S, Van Dycke A, Boon P, Raedt R.   +6 more
europepmc   +1 more source