Results 1 to 10 of about 62,280 (291)

Adenosine-Metabolizing Enzymes, Adenosine Kinase and Adenosine Deaminase, in Cancer [PDF]

Biomolecules, 2022
The immunosuppressive effect of adenosine in the microenvironment of a tumor is well established. Presently, researchers are developing approaches in immune therapy that target inhibition of adenosine or its signaling such as CD39 or CD73 inhibiting ...
Galina Zhulai, Eugenia Oleinik, Mikhail Shibaev, Kirill Ignatev   +3 more
doaj   +2 more sources

STUDY THE EFFECT OF ADENOSINE DEAMINASE ENZYME IN INDUCES CYTOGENETIC AND HISTOPATHOLOGICAL CHANGES IN RATS SKIN AND EYES TREATED WITH SUMICIDIN

The Iraqi Journal of Veterinary Medicine, 2000
The present investigation aimed to study the Adenosine Deaminase activity in induction Cytogentic and histopathological change in skin and eyes of sumicidine treated rats. The study Included. 1-Adenosine deaminase activity . 2-Total serum protein.
Bushra Ibrahim Al-Qaisi
doaj   +3 more sources

Deficiency of Adenosine Deaminase 2 [PDF]

Turkish Journal of Hematology
Adenosine deaminase 2 (ADA2) deficiency is an autosomal recessively inherited autoinflammatory disorder caused by loss-of-function mutations in the ADA2 gene. Although the pathogenesis involves the triggering of a proinflammatory cascade due to increased
Çağrı Coşkun, Şule Ünal
doaj   +2 more sources

Adenosine deaminase deficiency: a review [PDF]

Orphanet Journal of Rare Diseases, 2018
Adenosine deaminase (ADA) deficiency leads to an accumulation of toxic purine degradation by-products, most potently affecting lymphocytes, leading to adenosine deaminase-deficient severe combined immunodeficiency.
Aisling M. Flinn, Andrew R. Gennery
doaj   +3 more sources

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases [PDF]

Nature Methods, 2019
We present in vivo sequence-specific RNA base editing via adenosine deaminases acting on RNA (ADAR) enzymes with associated ADAR guide RNAs (adRNAs). To achieve this, we systematically engineered adRNAs to harness ADARs, and comprehensively evaluated the
Dhruva Katrekar, Genghao Chen, Dario Meluzzi   +2 more
exaly   +3 more sources

Adenosine deaminase acting on RNA 1 (ADAR1) as crucial regulators in cardiovascular diseases: structures, pathogenesis, and potential therapeutic approach

Frontiers in Pharmacology, 2023
Cardiovascular diseases (CVDs) are a group of diseases that have a major impact on global health and are the leading cause of death. A large number of chemical base modifications in ribonucleic acid (RNA) are associated with cardiovascular diseases.
Jieying Chen, Junyan Jin, Junyan Jin, Jun Jiang, Jun Jiang, Yaping Wang, Yaping Wang   +6 more
doaj   +1 more source

Adenosine deaminase, guanase

Japanese journal of MHTS, 1986
江頭 静摩, 山崎 晴一朗
openalex   +3 more sources

Serum Adenosine Deaminase as a Useful Marker to Estimate Coronary Artery Calcification in Type 2 Diabetes Mellitus Patients

Clinical and Applied Thrombosis/Hemostasis, 2021
We investigated the association between serum adenosine deaminase and coronary artery calcification (CAC) in type 2 diabetes mellitus (T2DM) patients.
Ming Yu M.Med, Hanyun Zhou M.Med, Qingan Li MB, Juan Ding MB, Hongxia Shuai PhD, Ji Zhang MB   +5 more
doaj   +1 more source

Adenosine deaminase as a marker for the severity of infectious mononucleosis secondary to EBV in children

BMC Infectious Diseases, 2022
Background Infectious mononucleosis, a common disease in children and young adults, is often accompanied by elevated transaminase levels and rarely, liver failure.
Ting Shi, Jungen Li, Yuzhu Miao, Linlin Huang, Jianmei Tian   +4 more
doaj   +1 more source

Role of serum and pleural adenosine deaminase activity compared to pleural fluid analysis in patients with pleural effusion of various etiology

MRIMS Journal of Health Sciences, 2023
Background: Numerous tests are available for determining the cause of exudate, but all these tests lack sensitivity and specificity, and they are not generally available.
Mubasheer Ali, Prashant Janjal, M V Raghavendra Rao   +2 more
doaj   +1 more source