Results 151 to 160 of about 29,706 (209)

Adenosine deaminase inhibition

International Journal of Biological Macromolecules, 2019
Adenosine deaminase is a critical enzyme in purine metabolism that regulates intra and extracellular adenosine concentrations by converting it to inosine. Adenosine is an important purine that regulates numerous physiological functions by interacting with its receptors.
Bagheri, S., Saboury, A.A., Haertle, T.
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Adenosine Deaminase Deficiency

Hospital Practice, 1987
Inherited deficiency of the purine salvage enzyme adenosine deaminase (ADA) is responsible for approximately half the cases of autosomal recessive Severe Combined Immunodeficiency (SCID). Deficiency of ADA can also result in a much later-onset, milder immunodeficiency, while lesser degrees of enzyme deficiency can result in either late-onset ...
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Adenosine deaminase inhibitors: Differential effects on multiple forms of adenosine deaminase

Biochemical and Biophysical Research Communications, 1978
Summary Three forms of calf intestine adenosine deaminase were resolved by gel filtrat in Sephacryl C-200 into species of 38,000 (E S ), 57,000 (E I ) and greater than 200,00 (E L ) daltons. The sensitivities of the three forms of adenosine deaminase to the adenosine deaminase inhibitors, 2′-deoxycoformycin (dCF) and erythro-9-(2-hydroxynonyl)adenine
J, Constine, R I, Glazer, D G, Johns
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The use of adenosine deaminase and adenosine deaminase isoenzymes in the diagnosis of tuberculous pleuritis

Current Opinion in Pulmonary Medicine, 2000
The bacillary population described in tuberculous pleuritis is small, and its most likely pathogenetic mechanism is essentially immunologic. This explains why, until now, the diagnostic identification of tuberculous pleuritis (TP) has been based on the presence of granulomas in pleural biopsy.
E, Pérez-Rodriguez, D, Jiménez Castro
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Treatment of Adenosine Deaminase Deficiency with Polyethylene Glycol–Modified Adenosine Deaminase

New England Journal of Medicine, 1987
We treated two children who had adenosine deaminase deficiency and severe combined immunodeficiency disease by injecting bovine adenosine deaminase modified by conjugation with polyethylene glycol. The modified enzyme was rapidly absorbed after intramuscular injection and had a half-life in plasma of 48 to 72 hours.
Michael S. Hershfield, Rebecca H. Buckley, Michael L. Greenberg, Alton L. Melton, Richard Schiff, Christine Hatem, Joanne Kurtzberg, M. Louise Markert, Roger H. Kobayashi, Ai Lan Kobayashi, Abraham Abuchowski   +10 more
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Immunohistochemistry of Adenosine Deaminase: Implications for Adenosine Neurotransmission

Science, 1984
Immunohistochemical analysis of adenosine deaminase in rat brain revealed an extensive plexus of adenosine deaminase-containing neurons in the basal hypothalamus. These neurons converged on and were most numerous in three major centers, namely, the tuberal, caudal, and postmammillary caudal magnocellular nuclei.
J I, Nagy, L A, LaBella, M, Buss, P E, Daddona   +3 more
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Novel substrate of adenosine deaminase

Biochemical and Biophysical Research Communications, 1971
Abstract Adenosine deaminase (from calf intestinal mucosa) converts 8,2′-anhydro-8-mercap to-9-β-D-arabinofuranosyladenine (II)) into 8,2′-anhydro-8-mercapto-9-β-D-arabinofuranosylhypoxanthine (III) with Km of 2.0 × 10−4M and V max equal to 7% that of adenosine. This conversion serves as a useful preparative synthesis of III. Further the fact that II
K K, Ogilvie, L, Slotin, P, Rheault
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Effect of adenosine deaminase on cardiac interstitial adenosine

American Journal of Physiology-Heart and Circulatory Physiology, 1992
Adenosine deaminase was infused into isolated perfused guinea pig hearts to determine its effect on myocardial adenosine levels. The enzyme was administered during constant coronary flow perfusion at 6.11 +/- 0.36 ml.min-1.g-1. Venous adenosine was measured in samples of pulmonary artery effluent; epicardial and endocardial adenosine were measured ...
Q, Zhu, G P, Matherne, R R, Curnish, C G, Tribble, R M, Berne   +4 more
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ADENOSINE DEAMINASE IN HUMAN SKIN

The Journal of Dermatology, 1981
ABSTRACTAdenosine deaminase (adenosine aminohydrolase, ADA), which catalyzes the deamination of adenosine to yield inosine and ammonia, was assayed in human penile foreskin.The skin tissue was separated into two layers; epidermis and dermis. ADA was found to be present in both layers (epidermis, 0.24 ΔoD/mg protein; dermis, 0.19 ΔOD/mg protein) with ...
Y P, Kim, J B, Kahng, J Y, Chon, C W, Ihm   +3 more
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Adenosine deaminase polymorphism in sardinia

Human Genetics, 1971
Red blood cell adenosine deaminase and G-6-PD polymorphisms have been studied in the populations of 17 Sardinian villages located at various altitudes. A total of 1615 individuals of both sexes, with age between 7 and 14 years were examined.
P, Lucarelli, R, Agostino, R, Palmarino, E, Bottini   +3 more
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