Results 151 to 160 of about 29,859 (206)

Treatment of Adenosine Deaminase Deficiency with Polyethylene Glycol–Modified Adenosine Deaminase

New England Journal of Medicine, 1987
We treated two children who had adenosine deaminase deficiency and severe combined immunodeficiency disease by injecting bovine adenosine deaminase modified by conjugation with polyethylene glycol. The modified enzyme was rapidly absorbed after intramuscular injection and had a half-life in plasma of 48 to 72 hours.
Michael S. Hershfield, Rebecca H. Buckley, Michael L. Greenberg, Alton L. Melton, Richard Schiff, Christine Hatem, Joanne Kurtzberg, M. Louise Markert, Roger H. Kobayashi, Ai Lan Kobayashi, Abraham Abuchowski   +10 more
openaire   +2 more sources

Immunohistochemistry of Adenosine Deaminase: Implications for Adenosine Neurotransmission

Science, 1984
Immunohistochemical analysis of adenosine deaminase in rat brain revealed an extensive plexus of adenosine deaminase-containing neurons in the basal hypothalamus. These neurons converged on and were most numerous in three major centers, namely, the tuberal, caudal, and postmammillary caudal magnocellular nuclei.
J I, Nagy, L A, LaBella, M, Buss, P E, Daddona   +3 more
openaire   +2 more sources

Novel substrate of adenosine deaminase

Biochemical and Biophysical Research Communications, 1971
Abstract Adenosine deaminase (from calf intestinal mucosa) converts 8,2′-anhydro-8-mercap to-9-β-D-arabinofuranosyladenine (II)) into 8,2′-anhydro-8-mercapto-9-β-D-arabinofuranosylhypoxanthine (III) with Km of 2.0 × 10−4M and V max equal to 7% that of adenosine. This conversion serves as a useful preparative synthesis of III. Further the fact that II
K K, Ogilvie, L, Slotin, P, Rheault
openaire   +4 more sources

Effect of adenosine deaminase on cardiac interstitial adenosine

American Journal of Physiology-Heart and Circulatory Physiology, 1992
Adenosine deaminase was infused into isolated perfused guinea pig hearts to determine its effect on myocardial adenosine levels. The enzyme was administered during constant coronary flow perfusion at 6.11 +/- 0.36 ml.min-1.g-1. Venous adenosine was measured in samples of pulmonary artery effluent; epicardial and endocardial adenosine were measured ...
Q, Zhu, G P, Matherne, R R, Curnish, C G, Tribble, R M, Berne   +4 more
openaire   +2 more sources

ADENOSINE DEAMINASE IN HUMAN SKIN

The Journal of Dermatology, 1981
ABSTRACTAdenosine deaminase (adenosine aminohydrolase, ADA), which catalyzes the deamination of adenosine to yield inosine and ammonia, was assayed in human penile foreskin.The skin tissue was separated into two layers; epidermis and dermis. ADA was found to be present in both layers (epidermis, 0.24 ΔoD/mg protein; dermis, 0.19 ΔOD/mg protein) with ...
Y P, Kim, J B, Kahng, J Y, Chon, C W, Ihm   +3 more
openaire   +2 more sources

Adenosine deaminase polymorphism in sardinia

Human Genetics, 1971
Red blood cell adenosine deaminase and G-6-PD polymorphisms have been studied in the populations of 17 Sardinian villages located at various altitudes. A total of 1615 individuals of both sexes, with age between 7 and 14 years were examined.
P, Lucarelli, R, Agostino, R, Palmarino, E, Bottini   +3 more
openaire   +2 more sources

Adenosine deaminase and purinergic neuroregulation

Neurochemistry International, 1990
During the early 1970s purines and their associated enzymes were largely believed to be ubiquitous and evenly distributed throughout neural tissues. There is now firm immunohistochemical and neurochemical evidence that this is not the case for the catabolic enzyme adenosine deaminase (ADA) nor is it true for adenosine transport sites labelled by the ...
J I, Nagy, J D, Geiger, W A, Staines
openaire   +2 more sources

The linkage relationships of adenosine deaminase

Annals of Human Genetics, 1970
SUMMARYThe lod scores for seventy‐six families segregating for adenosine deaminase have been estimated. Taken in conjunction with other published lod scores there is a suggestion that ADA may be linked with P.
P J, Cook, D A, Hopkinson, E B, Robson
openaire   +2 more sources

Adenosine and Adenosine Deaminase Contrary Manifestations in Immunity

Scandinavian Journal of Immunology
ABSTRACTAdenosine (Ado) is an important purine that regulates numerous physiological functions. Adenosine deaminase (ADA) catalyses the irreversible deamination of Ado and its derivatives. Ado and ADA are the essential players in the immune system, but their roles often are opposite, mutually exclusive and competitive.
Sona Mardanyan, Luiza Karapetyan, Alvard Antonyan   +2 more
openaire   +2 more sources

Adenosine deaminase.

Methods in enzymology, 1977
Adenosine deaminase plays a key role in adenosine metabolism. This nueleoside has some important pharmacological and toxic effects. An adenosine deaminase deficiency observed in some cases of severe congenital immunodeficiency represents the first link between an immunological and enzymic defect.
Ronca G, LUCACCHINI, ANTONIO, Rossi C. A.   +2 more
openaire   +2 more sources