Results 191 to 200 of about 132,212 (243)

The use of adenosine deaminase and adenosine deaminase isoenzymes in the diagnosis of tuberculous pleuritis

Current Opinion in Pulmonary Medicine, 2000
The bacillary population described in tuberculous pleuritis is small, and its most likely pathogenetic mechanism is essentially immunologic. This explains why, until now, the diagnostic identification of tuberculous pleuritis (TP) has been based on the presence of granulomas in pleural biopsy.
E, Pérez-Rodriguez, D, Jiménez Castro
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Treatment of Adenosine Deaminase Deficiency with Polyethylene Glycol–Modified Adenosine Deaminase

New England Journal of Medicine, 1987
We treated two children who had adenosine deaminase deficiency and severe combined immunodeficiency disease by injecting bovine adenosine deaminase modified by conjugation with polyethylene glycol. The modified enzyme was rapidly absorbed after intramuscular injection and had a half-life in plasma of 48 to 72 hours.
Michael S. Hershfield, Rebecca H. Buckley, Michael L. Greenberg, Alton L. Melton, Richard Schiff, Christine Hatem, Joanne Kurtzberg, M. Louise Markert, Roger H. Kobayashi, Ai Lan Kobayashi, Abraham Abuchowski   +10 more
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Immunohistochemistry of Adenosine Deaminase: Implications for Adenosine Neurotransmission

Science, 1984
Immunohistochemical analysis of adenosine deaminase in rat brain revealed an extensive plexus of adenosine deaminase-containing neurons in the basal hypothalamus. These neurons converged on and were most numerous in three major centers, namely, the tuberal, caudal, and postmammillary caudal magnocellular nuclei.
J I, Nagy, L A, LaBella, M, Buss, P E, Daddona   +3 more
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ADENOSINE DEAMINASE IN HUMAN SKIN

The Journal of Dermatology, 1981
ABSTRACTAdenosine deaminase (adenosine aminohydrolase, ADA), which catalyzes the deamination of adenosine to yield inosine and ammonia, was assayed in human penile foreskin.The skin tissue was separated into two layers; epidermis and dermis. ADA was found to be present in both layers (epidermis, 0.24 ΔoD/mg protein; dermis, 0.19 ΔOD/mg protein) with ...
Y P, Kim, J B, Kahng, J Y, Chon, C W, Ihm   +3 more
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Adenosine Deaminase and Thymocyte Maturation

Scandinavian Journal of Immunology, 1991
The congenital absence of adenosine deaminase in humans results in severe combined immunodeficiency. To clarity the process whereby thymocytes are destroyed in the absence of adenosine deaminase activity, we induced a parallel condition in mice through the injection of an inhibitor of adenosine deaminase, deoxycoformycin.
P J, Doherty, S, Pan, J C, Mulloy, E, Thompson, P, Thorner, J, Barankiewiecz, C M, Roifman, A, Cohen   +7 more
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Adenosine deaminase polymorphism in sardinia

Human Genetics, 1971
Red blood cell adenosine deaminase and G-6-PD polymorphisms have been studied in the populations of 17 Sardinian villages located at various altitudes. A total of 1615 individuals of both sexes, with age between 7 and 14 years were examined.
P, Lucarelli, R, Agostino, R, Palmarino, E, Bottini   +3 more
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Adenosine deaminase and purinergic neuroregulation

Neurochemistry International, 1990
During the early 1970s purines and their associated enzymes were largely believed to be ubiquitous and evenly distributed throughout neural tissues. There is now firm immunohistochemical and neurochemical evidence that this is not the case for the catabolic enzyme adenosine deaminase (ADA) nor is it true for adenosine transport sites labelled by the ...
J I, Nagy, J D, Geiger, W A, Staines
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Novel substrate of adenosine deaminase

Biochemical and Biophysical Research Communications, 1971
Abstract Adenosine deaminase (from calf intestinal mucosa) converts 8,2′-anhydro-8-mercap to-9-β-D-arabinofuranosyladenine (II)) into 8,2′-anhydro-8-mercapto-9-β-D-arabinofuranosylhypoxanthine (III) with Km of 2.0 × 10−4M and V max equal to 7% that of adenosine. This conversion serves as a useful preparative synthesis of III. Further the fact that II
K K, Ogilvie, L, Slotin, P, Rheault
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The linkage relationships of adenosine deaminase

Annals of Human Genetics, 1970
SUMMARYThe lod scores for seventy‐six families segregating for adenosine deaminase have been estimated. Taken in conjunction with other published lod scores there is a suggestion that ADA may be linked with P.
P J, Cook, D A, Hopkinson, E B, Robson
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Adenosine and Adenosine Deaminase Contrary Manifestations in Immunity

Scandinavian Journal of Immunology
ABSTRACTAdenosine (Ado) is an important purine that regulates numerous physiological functions. Adenosine deaminase (ADA) catalyses the irreversible deamination of Ado and its derivatives. Ado and ADA are the essential players in the immune system, but their roles often are opposite, mutually exclusive and competitive.
Sona Mardanyan, Luiza Karapetyan, Alvard Antonyan   +2 more
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