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Treatment of Adenosine Deaminase Deficiency with Polyethylene Glycol–Modified Adenosine Deaminase
New England Journal of Medicine, 1987We treated two children who had adenosine deaminase deficiency and severe combined immunodeficiency disease by injecting bovine adenosine deaminase modified by conjugation with polyethylene glycol. The modified enzyme was rapidly absorbed after intramuscular injection and had a half-life in plasma of 48 to 72 hours.
Michael S. Hershfield +10 more
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Methods in enzymology, 1977
Adenosine deaminase plays a key role in adenosine metabolism. This nueleoside has some important pharmacological and toxic effects. An adenosine deaminase deficiency observed in some cases of severe congenital immunodeficiency represents the first link between an immunological and enzymic defect.
Ronca G +2 more
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Adenosine deaminase plays a key role in adenosine metabolism. This nueleoside has some important pharmacological and toxic effects. An adenosine deaminase deficiency observed in some cases of severe congenital immunodeficiency represents the first link between an immunological and enzymic defect.
Ronca G +2 more
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Novel substrate of adenosine deaminase
Biochemical and Biophysical Research Communications, 1971Abstract Adenosine deaminase (from calf intestinal mucosa) converts 8,2′-anhydro-8-mercap to-9-β-D-arabinofuranosyladenine (II)) into 8,2′-anhydro-8-mercapto-9-β-D-arabinofuranosylhypoxanthine (III) with Km of 2.0 × 10−4M and V max equal to 7% that of adenosine. This conversion serves as a useful preparative synthesis of III. Further the fact that II
K K, Ogilvie, L, Slotin, P, Rheault
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Adenosine deaminase polymorphism in sardinia
Human Genetics, 1971Red blood cell adenosine deaminase and G-6-PD polymorphisms have been studied in the populations of 17 Sardinian villages located at various altitudes. A total of 1615 individuals of both sexes, with age between 7 and 14 years were examined.
P, Lucarelli +3 more
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Nihon rinsho. Japanese journal of clinical medicine, 1995
Adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4; ADA) activity is widely distributed in human tissues and is highest in lymphoid tissues. Two ADA isozymes are known as ADA1 and ADA2. Human tissue extracts contained ADA1 predominantly. Meanwhile, ADA2 was the main component of serum ADA. ADA activity was significantly elevated in the sera from
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Adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4; ADA) activity is widely distributed in human tissues and is highest in lymphoid tissues. Two ADA isozymes are known as ADA1 and ADA2. Human tissue extracts contained ADA1 predominantly. Meanwhile, ADA2 was the main component of serum ADA. ADA activity was significantly elevated in the sera from
openaire +1 more source
ADENOSINE DEAMINASE IN HUMAN SKIN
The Journal of Dermatology, 1981ABSTRACTAdenosine deaminase (adenosine aminohydrolase, ADA), which catalyzes the deamination of adenosine to yield inosine and ammonia, was assayed in human penile foreskin.The skin tissue was separated into two layers; epidermis and dermis. ADA was found to be present in both layers (epidermis, 0.24 ΔoD/mg protein; dermis, 0.19 ΔOD/mg protein) with ...
Y P, Kim +3 more
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1977
Publisher Summary Adenosine deaminase plays a key role in adenosine metabolism. This nueleoside has some important pharmacological and toxic effects. An adenosine deaminase deficiency observed in some cases of severe congenital immunodeficiency represents the first link between an immunological and enzymic defect.
Giovanni Ronca +2 more
openaire +1 more source
Publisher Summary Adenosine deaminase plays a key role in adenosine metabolism. This nueleoside has some important pharmacological and toxic effects. An adenosine deaminase deficiency observed in some cases of severe congenital immunodeficiency represents the first link between an immunological and enzymic defect.
Giovanni Ronca +2 more
openaire +1 more source
The adenosine pathway in immuno-oncology
Nature Reviews Clinical Oncology, 2020Bertrand Allard +2 more
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