Results 291 to 300 of about 238,585 (333)

Treatment of Adenosine Deaminase Deficiency with Polyethylene Glycol–Modified Adenosine Deaminase

New England Journal of Medicine, 1987
We treated two children who had adenosine deaminase deficiency and severe combined immunodeficiency disease by injecting bovine adenosine deaminase modified by conjugation with polyethylene glycol. The modified enzyme was rapidly absorbed after intramuscular injection and had a half-life in plasma of 48 to 72 hours.
Richard I. Schiff, Richard I. Schiff, Richard I. Schiff, Christine L. Hatem, Christine L. Hatem, Christine L. Hatem, Rebecca H. Buckley, Rebecca H. Buckley, Rebecca H. Buckley, A L Kobayashi, A L Kobayashi, A L Kobayashi, R H Kobayashi, R H Kobayashi, R H Kobayashi, Joanne Kurtzberg, Joanne Kurtzberg, Joanne Kurtzberg, Michael L. Greenberg, Michael L. Greenberg, Michael L. Greenberg, A L Melton, A L Melton, A L Melton, M L Markert, M L Markert, M L Markert, Michael S. Hershfield, Michael S. Hershfield, Michael S. Hershfield   +29 more
openaire   +3 more sources

Novel substrate of adenosine deaminase

Biochemical and Biophysical Research Communications, 1971
Abstract Adenosine deaminase (from calf intestinal mucosa) converts 8,2′-anhydro-8-mercap to-9-β-D-arabinofuranosyladenine (II)) into 8,2′-anhydro-8-mercapto-9-β-D-arabinofuranosylhypoxanthine (III) with Km of 2.0 × 10−4M and V max equal to 7% that of adenosine. This conversion serves as a useful preparative synthesis of III. Further the fact that II
Lewis A. Slotin, Kelvin K. Ogilvie, Pat Rheault   +2 more
openaire   +6 more sources

Adenosine Deaminase Deficiency

Hospital Practice, 1987
Inherited deficiency of the purine salvage enzyme adenosine deaminase (ADA) is responsible for approximately half the cases of autosomal recessive Severe Combined Immunodeficiency (SCID). Deficiency of ADA can also result in a much later-onset, milder immunodeficiency, while lesser degrees of enzyme deficiency can result in either late-onset ...
openaire   +4 more sources

Adenosine deaminase polymorphism in sardinia

Human Genetics, 1971
Red blood cell adenosine deaminase and G-6-PD polymorphisms have been studied in the populations of 17 Sardinian villages located at various altitudes. A total of 1615 individuals of both sexes, with age between 7 and 14 years were examined.
E. Bottini, R. Agostino, Paola Lucarelli, R. Palmarino   +3 more
openaire   +3 more sources

Human adenosine deaminase 2 deficiency: A multi‐faceted inborn error of immunity

Immunological Reviews, 2019
Human adenosine deaminase 1 deficiency was described in the 1970s to cause severe combined immunodeficiency. The residual adenosine deaminase activity in these patients was attributed to adenosine deaminase 2. Human adenosine deaminase type 2 deficiency (
Leen Moens, M. Hershfield, K. Arts, I. Aksentijevich, I. Meyts   +4 more
semanticscholar   +1 more source

ADENOSINE DEAMINASE IN HUMAN SKIN

The Journal of Dermatology, 1981
ABSTRACTAdenosine deaminase (adenosine aminohydrolase, ADA), which catalyzes the deamination of adenosine to yield inosine and ammonia, was assayed in human penile foreskin.The skin tissue was separated into two layers; epidermis and dermis. ADA was found to be present in both layers (epidermis, 0.24 ΔoD/mg protein; dermis, 0.19 ΔOD/mg protein) with ...
Joon Yul Chon, Young Pio Kim, Chull Wan Ihm, Johng Bong Kahng   +3 more
openaire   +3 more sources

Erythrocyte Adenosine Deaminase in Malaysians

Human Heredity, 1975
944 adenosine deaminase phenotypings of Malay, Chinese, and Indian blood donors and newborns at Kuala Lumpur, Malaysia, yielded ADA1 gene frequency estimates of 0.885 for the Malays, 0.939 for the Chinese, and 0.853 for the Indians.
Q.B. Welch, Luan Eng Lie-Injo, J. Ganesan   +2 more
openaire   +3 more sources

Adenosine deaminase.

Methods in enzymology, 1977
Adenosine deaminase plays a key role in adenosine metabolism. This nueleoside has some important pharmacological and toxic effects. An adenosine deaminase deficiency observed in some cases of severe congenital immunodeficiency represents the first link between an immunological and enzymic defect.
Ronca G, LUCACCHINI, ANTONIO, Rossi C. A.   +2 more
openaire   +2 more sources

Adenosine Deaminase and Thymocyte Maturation

Scandinavian Journal of Immunology, 1991
The congenital absence of adenosine deaminase in humans results in severe combined immunodeficiency. To clarity the process whereby thymocytes are destroyed in the absence of adenosine deaminase activity, we induced a parallel condition in mice through the injection of an inhibitor of adenosine deaminase, deoxycoformycin.
J. Barankiewiecz, S. Pan, P. Thorner, A. Cohen, P J Doherty, E. Thompson, C. M. Roifman, J. C. Mulloy   +7 more
openaire   +3 more sources

Adenosine deaminase and purinergic neuroregulation

Neurochemistry International, 1990
During the early 1970s purines and their associated enzymes were largely believed to be ubiquitous and evenly distributed throughout neural tissues. There is now firm immunohistochemical and neurochemical evidence that this is not the case for the catabolic enzyme adenosine deaminase (ADA) nor is it true for adenosine transport sites labelled by the ...
William A. Staines, James I. Nagy, Jonathan D. Geiger   +2 more
openaire   +3 more sources