4-Thioribose Analogues of Adenosine Diphosphate Ribose (ADPr) Peptides. [PDF]
Org Lett, 2023 Madern JM +7 more
europepmc +1 more source
RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists. [PDF]
, 2018 Platelets express ≥2 members of the regulators of G protein signaling (RGS) family. Here, we have focused on the most abundant, RGS10, examining its impact on the hemostatic response in vivo and the mechanisms involved.
Brass, Lawrence F. +7 more
core +1 more source
Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies
VIEW, EarlyView.This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li +5 more
wiley +1 more source
Role of the phosphocreatine system on energetic homeostasis in skeletal and cardiac muscles
Einstein (São Paulo)Adenosine triphosphate is the present energy currency in the body, and is used in various cellular and indispensable processes for the maintenance of cell homeostasis.
Lucas Guimarães-Ferreira
doaj +1 more source
From mechanism to phenotype: What fits in a basket trial
Epilepsia, EarlyView.
Kette D. Valente
wiley +1 more source
Artificial Organs, EarlyView.Graphical summary of the experimental comparison of shear‐induced hemolysis in pediatric and adult blood using a Couette shearing device. Pediatric blood shows a trend toward lower increase in hemolysis at higher shear stress amplitudes, while no relevant differences are observed at low and intermediate stresses.
Vera Froese +4 more
wiley +1 more source
Терапевтический архив, 2013 The review presents the current data available in the world literature on the most likely gene polymorphisms, such as cyclooxygenase, glycoproteins (GP) Ib/IIIa, GP Ibα, GP VI, adenosine diphosphate receptor P2Y1 and P2Y12 polymorphisms that may lead to ...
Iu I Grinshteĭn +2 more
doaj
Nutrition-Based Modulation of Poly-ADP-Ribosylation and its possible role in Alzheimer’s disease [PDF]
, 2015 Alzheimer’s Disease (AD) is the most common neurodegenerative disease and the main reason of dementia in the elderly. On the pathological point of view, it is characterized by extracellular aggregates of amyloid peptides and intracellular deposits of tau
Fuso, Andrea, Martire, Sara
core
Bleeding Disorders in Children With Genetic Diseases: A Narrative Review
Acta Paediatrica, EarlyView.ABSTRACT Aim The lack of data on bleeding risk assessment in children with genetic diseases is concerning given their increased care needs and risk of haemorrhagic complications compared to the general population. Identification of haemostatic disorders is crucial for implementing preventive measures and mitigating bleeding risk.
Raphaelle Cagol +6 more
wiley +1 more source
Unlocking Therapeutic Potential of Poly(Adenosine Diphosphate Ribose) Polymerase (PARP) Inhibitors in Metastatic Breast Cancer With BRCA Gene Mutations: A Narrative Review. [PDF]
Cureus, 2023 Jain P.
europepmc +1 more source