Harnessing nucleotide metabolism and immunity in cancer: a tumour microenvironment perspective
The FEBS Journal, EarlyView.This review explores how changes in nucleotide metabolism affect the tumour microenvironment and immune responses in cancer. Here, we discuss the dual role of nucleotide metabolism in promoting cancer cell growth and shaping immune suppression. We highlight how therapies targeting nucleotide pathways can enhance immunotherapy efficacy, offering new ...
Hadil Suleiman +5 more
wiley +1 more source
Energetics of the Citric Acid Cycle in the Deep Biosphere
Geophysical Monograph Series, Page 303-327., 2020 This book is Open Access. A digital copy can be downloaded for free from Wiley Online Library.
Explores the behavior of carbon in minerals, melts, and fluids under extreme conditions
Carbon trapped in diamonds and carbonate-bearing rocks in subduction zones are examples of the continuing exchange of substantial carbon ...
Peter A. Canovas III, Everett L. Shock
wiley +1 more source
Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors as maintenance therapy in women with newly diagnosed ovarian cancer: a systematic review and meta-analysis. [PDF]
Arch Gynecol Obstet, 2021 Cheng H, Yang J, Liu H, Xiang Y.
europepmc +1 more source
The potential clinical value of platelet aggregation in colorectal tumor progression
Discover OncologyObjective The present study is to examine whether platelet aggregation function, platelet count and mean platelet volume are indicators that related to clinicopathological characteristics of colorectal cancer.
Yuyu Chen +5 more
doaj +1 more source
FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries
The FEBS Journal, EarlyView.This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio +9 more
wiley +1 more source
Kinetic and Static Analysis of Poly-(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET Images of Ovarian Cancer. [PDF]
J Nucl Med, 2022 Young AJ +14 more
europepmc +1 more source
The FEBS Journal, EarlyView.Variants at position R196 in cytoskeletal β‐actin are the most common variants associated with Baraitser–Winter cerebrofrontofacial syndrome and result in craniofacial anomalies and neurodevelopmental disorders, most likely due to neuronal migration defects. This study explores the molecular mechanisms of p.R196 variants using purified proteins.
Johannes N. Greve, Dietmar J. Manstein
wiley +1 more source
Tumor treating fields combined with a poly (adenosine diphosphate-ribose) polymerase inhibitor during radiotherapy for rapidly progressing IDH-wildtype diffuse astrocytoma: a case report. [PDF]
J Int Med Res, 2021 Wang Z, Ren Y, Du F, Sun Y, Jiang W.
europepmc +1 more source
Cell Communication and SignalingBackground Clinical and experimental studies have shown that the myocardial inflammatory response during pathological events varies between males and females. However, the cellular and molecular mechanisms of these sex differences remain elusive.
Marie Louise Ndzie Noah +11 more
doaj +1 more source