Tirzepatide and SGLT2 inhibitors act through distinct but complementary mechanisms in obesity‐related HFpEF: tirzepatide targets adiposity, inflammation, and insulin resistance, while SGLT2 inhibitors improve decongestion, myocardial energetics, and cardiac remodeling.
Zakariye Isak Mohamed +8 more
wiley +1 more source
Adenosine diphosphate released from stressed cells triggers mitochondrial transfer to achieve tissue homeostasis. [PDF]
Li H +16 more
europepmc +1 more source
Synthetic Food Colorants and Gut Microbiota: A Systematic Review of Preclinical Studies
ABSTRACT Growing evidence suggests that industrial food processing, including the excess consumption of food additives, might have a negative impact on human health. Despite regulatory safety evaluations, their impact on gut microbiota remains poorly characterized.
Sebastiano Alfio Torrisi +9 more
wiley +1 more source
Poly(Adenosine Diphosphate Ribose) Polymerase (PARP) Inhibitors in the Treatment of Advanced Ovarian Cancer: A Narrative Review. [PDF]
Dewani D, Jaiswal A, Karwade P.
europepmc +1 more source
Studies on Poly (Adenosine Diphosphate Ribose)
Hirotaka Matsubara +5 more
openaire +1 more source
ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation,
Nawfal Hasan Siam +8 more
wiley +1 more source
Influence of Magnesium Ion Binding on the Adenosine Diphosphate Structure and Dynamics, Investigated by <sup>31</sup>P NMR and Molecular Dynamics Simulations. [PDF]
Marr KA, Korenchan DE, Jerschow A.
europepmc +1 more source
Intelligent design of artificial biocatalyst for biomedical diseases
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang +3 more
wiley +1 more source
A switch-on luminescent europium(iii) probe for selective and time-resolved detection of adenosine diphosphate (ADP). [PDF]
Bodman SE +5 more
europepmc +1 more source
Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa +2 more
wiley +1 more source

