Results 191 to 200 of about 163,297 (275)

Nitric Oxide in Cancer: Mechanisms, Dual Role, and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Nitric oxide exerts concentration‐dependent dual roles in cancer, functioning as either a tumor promoter or suppressor. This review comprehensively examines NO's multifaceted regulation of tumor biology, including S‐nitrosylation signaling, metabolic reprogramming, immunemodulation, and therapy resistance, and highlights emerging therapeutic strategies
Jia Shao, Honghua Zhang, Jingyu Chen, Ziyu Qian, Ning Zhang, Yihua Zhang, Hui Ye, Jianbing Wu, Zhangjian Huang   +8 more
wiley   +1 more source

Quaternary structures of Streptococcus pneumoniae nucleoside diphosphate kinase: From hexamers to supramolecular assemblies

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The nucleoside diphosphate kinase (NDK) is a key enzyme that controls the balance of nucleotide pools in all living organisms. Beyond this fundamental role, NDKs exert pleiotropic effects in many cellular processes, including cell development, signal transduction, differentiation, tumor metastasis, and gene expression. The quaternary structure
Julie Kerboeuf, Paul Nouri, Frédéric Galisson, Laetitia Daury, Marie‐France Giraud, Olivier Lambert, Cédric Orelle, Lionel Ballut, Elise Kaplan, Jean‐Michel Jault, Cécile Gonzalez   +10 more
wiley   +1 more source

Latin American Challenges and Recommendations for Poly Adenosine Diphosphate Ribose Polymerase Inhibitor Treatment in Metastatic Castration Resistant Prostate Cancer: An Expert Overview. [PDF]

Cancer Control
Borges Dos Reis R, Aguilar-Ponce JL, Cayol F, Jansen AM, K RM, Merino TR, Sanku G, Vaca LB, Isaacsson Velho P, Korbenfeld EP.   +9 more
europepmc   +1 more source

Differential sensitivity of various markers of platelet activation with adenosine diphosphate. [PDF]

Bionanoscience, 2019
Le Minh G, Peshkova AD, Andrianova IA, Weisel JW, Litvinov RI.   +4 more
europepmc   +1 more source

Structural and functional insights into Pseudomonas aeruginosa ApaH, a diadenosine tetraphosphatase crucial for bacterial virulence

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Infections by Pseudomonas aeruginosa are a major cause of severe morbidity and mortality in immunocompromised patients and people with cystic fibrosis, largely due to the pathogen's ability to resist antibiotic treatment and to deploy multiple virulence strategies that promote persistence in the host.
Gianluca Pistoia, Matteo Cervoni, Flavia Catalano, Francesca Troilo, Francesca Guidi, Eleonora Comparini, Giuseppina Mignogna, Carlo Travaglini‐Allocatelli, Alessandro Giuffrè, Antonio Coluccia, Francesco Imperi, Adele Di Matteo, Giorgio Giardina   +12 more
wiley   +1 more source

P2Y12 receptor gene mutations associated with bleeding

Platelets, 2017
Mariangela Scavone, Eti A. Femia, Marco Cattaneo   +2 more
doaj   +1 more source

Development and Clinical Utility of Machine Learning Models for Prediction of Same‐Day Discharge in Outpatient Hip and Knee Replacement: A Prognostic Study

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 8, September 2026.
ABSTRACT Background Hip and knee replacement are common procedures with an increasing focus on same‐day surgery. However, capacity constraints limit the number of eligible patients actually being scheduled for same‐day discharge, calling for further selection of those with the highest likelihood of same‐day discharge.
Christoffer C. Jørgensen, Jakob B. Frederiksen, Henrik Kehlet, Martin Lindberg‐Larsen, Kirill Gromov, Claus Varnum, Thomas Jakobsen, Manuel Josef Bieder, Mikkel Rathsach Andersen, Søren Overgaard, Torben B. Hansen, Troels Petersen   +11 more
wiley   +1 more source

Platelet function in patients undergoing major non‐cardiac vascular surgery (PLUGS): a prospective cohort study*

Anaesthesia, Volume 81, Issue 9, Page 1236-1244, September 2026.
Summary Introduction Patients who require major vascular surgery often receive antiplatelet therapy for primary or secondary prevention of cardiovascular disease. Clopidogrel resistance and variability in platelet recovery after drug discontinuation pose clinical challenges, particularly for regional anaesthesia and blood management.
Akshay Shah, Grace Polley, Kasia Bera, Keith Maher, Stephen Von‐Kier, Antonio Barbosa, Louis Corrigan, Sabeena Sharma, Peter Baker, Stuart R. McKechnie, Michael J. Desborough, on behalf of the PLUGS Investigators   +11 more
wiley   +1 more source

Positron Emission Tomography Imaging of Poly-(Adenosine Diphosphate-Ribose) Polymerase 1 Expression in Breast Cancer: A Nonrandomized Clinical Trial.

JAMA Oncol, 2020
McDonald ES, Doot RK, Pantel AR, Farwell MD, Mach RH, Maxwell KN, Mankoff DA.   +6 more
europepmc   +1 more source

Peripheral κ opioid receptor in pain and inflammation: From molecular signalling and gene expression to drug discovery

British Journal of Pharmacology, Volume 183, Issue 17, Page 5157-5189, September 2026.
The κ opioid receptor (κ receptor, KOR) is a G protein‐coupled receptor with well established roles in analgesia and immune modulation. Although historically studied primarily in the central nervous system (CNS), growing evidence indicates that κ signalling in peripheral tissues plays an important role in regulating pain, inflammation and immune ...
Rumsha Khan, Elena C. A. Becker, Boglarka B. Bata, Christian W. Gruber   +3 more
wiley   +1 more source