Results 161 to 170 of about 163,297 (275)

Membrane Fusion‐Mediated Cytosolic Delivery of Threose Nucleic Acids via Homotypic Nanoparticles Overcomes Drug Resistance in Triple‐Negative Breast Cancer

Advanced Science, Volume 13, Issue 50, 7 September 2026.
This study introduces a biomimetic “nanofusion” platform that integrates the biostability of threose nucleic acids (TNA) with homotypic cell‐membrane cloaking to combat drug‐resistant TNBC. By leveraging a non‐canonical membrane‐fusion pathway for direct cytosolic delivery, the platform bypasses endosomal sequestration. To achieve potent AKT2 silencing
Wei Zheng, Tristan Juin Han Chang, Xinchao Li, Zhongqi Zhou, Chung Tin, Kenward Vong, Pierre Karam, Pik Kwan Lo   +7 more
wiley   +1 more source

Model for Predicting Serious Hematological Adverse Events in Individuals With Ovarian Cancer Receiving Poly (Adenosine Diphosphate Ribose) Polymerase Inhibitor Treatment: Prospective Cohort Study. [PDF]

JMIR Med Inform
Lian X, Lei Y.
europepmc   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies

Advanced Science, Volume 13, Issue 50, 7 September 2026.
Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi, Mengsi Lu, Yue Zhang, Anuj Shukla, An‐Li Andrea Ko, Henning J. Jessen   +5 more
wiley   +1 more source

Platelet reactivity to adenosine diphosphate and <i>CYP2C19</i> genotypes are linked with carotid plaques and may predict carotid plaque stability in acute ischemic stroke patients. [PDF]

Neurosciences (Riyadh)
Shi H, Tang M, Wang T, Yang L, Lai X, Chen Y, Diao F, Chen X, Zuo J, Xu J, Zhong G, Dong Y.   +11 more
europepmc   +1 more source

Occurrence of Pancytopenia Among Patients With Cancer Treated With Poly(Adenosine Diphosphate-Ribose) Polymerase Inhibitors: A Pharmacoepidemiologic Study.

JAMA Oncol, 2021
Morice PM, Chrétien B, Da Silva A, Dolladille C, Alexandre J.   +4 more
europepmc   +1 more source

Quantum‐Level Influences on Enzyme Reactions and Their Ripple Effects on Biological Phenomena

Advanced Physics Research, Volume 5, Issue 9, September 2026.
Because living organisms are ultimately composed of atoms and molecules, quantum‐mechanical effects are expected to contribute to biological phenomena. Quantum biology seeks to elucidate life processes from a quantum‐mechanical perspective. This review discusses how quantum‐level effects, including quantum tunneling, may propagate from enzymatic proton‐
Takeshi Yasuda
wiley   +1 more source

First-in-Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN-3143, a Novel Inhibitor of Mono-Adenosine Diphosphate Ribosyltransferase-PARP14. [PDF]

Clin Pharmacol Drug Dev
Polasek TM, Cole A, Bozón V, Manyak E, Novak J, Yang B, Johnston BA, Parasuraman S, Paneliya KJ, Schuck V.   +9 more
europepmc   +1 more source

Patient cost sharing during poly(adenosine diphosphate-ribose) polymerase inhibitor treatment in ovarian cancer. [PDF]

Am J Obstet Gynecol, 2021
Harrison RF, Fu S, Sun CC, Zhao H, Lu KH, Giordano SH, Meyer LA.   +6 more
europepmc   +1 more source

Inosine‐Triphosphate‐Pyrophosphatase Activity as a Potential Predictor of Methotrexate Remission in Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, Volume 78, Issue 9, Page 1989-1999, September 2026.
Objective Methotrexate (MTX) is the first‐line therapy for juvenile idiopathic arthritis (JIA), but up to 40% of patients do not respond to it. Low inosine triphosphate pyrophosphatase (ITPA) activity has been associated with reduced clinical remission. We investigated the role and underlying mechanisms of ITPA in vitro. Methods ITPA enzymatic activity
Sofia Sindici Forgiarini, Marianna Lucafò, Debora Curci, Davide Selvestrel, Valentina Moressa, Sofia Pagarin, Barbara Bellich, Martina Franzin, Alberto Tommasini, Mara L. Becker, Laura B. Ramsey, Susan D. Thompson, Carl D. Langefeld, Federica Corba, Edoardo Marrani, Gabriele Simonini, Gabriele Stocco, Giuliana Decorti, Andrea Taddio, Serena Pastore   +19 more
wiley   +1 more source

Adenosine diphosphate stimulates VEGF-independent choroidal endothelial cell proliferation: A potential escape from anti-VEGF therapy. [PDF]

Proc Natl Acad Sci U S A
Biswas N, Mori T, Ragava Chetty Nagaraj NK, Xin H, Diemer T, Li P, Su Y, Piermarocchi C, Ferrara N.   +8 more
europepmc   +1 more source