Results 301 to 310 of about 296,423 (346)

Nonnucleoside Inhibitors of Adenosine Kinase

Current Pharmaceutical Design, 2004
Adenosine (ADO) is an endogenous inhibitory neuromodulator that increases nociceptive thresholds in response to tissue trauma and inflammation. Adenosine kinase (AK) is a key intracellular enzyme regulating intra- and extracellular concentrations of ADO.
Arthur, Gomtsyan, Chih-Hung, Lee
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Regulation of adenosine kinase by adenosine analogs.

Molecular Pharmacology, 1988
The regulation of adenosine phosphorylation by adenosine analogs was studied using highly purified human placental adenosine kinase [ATP: adenosine 5'-phosphotransferase (EC 2.7.1.20)]. Our observations lead us to classify the analogs into three groups as follows: type I, 5'-N-ethylcarboxamidoadenosine and 5'-methylthioadenosine; type II, N6 ...
B B, Lin, M C, Hurley, I H, Fox
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Adenosine Kinase Inhibitors

Current Pharmaceutical Design, 1998
Abstract: Adenosine (ADO) is an endogenous modulator of intercellular signaling that provides homeostatic reductions in cell excitability during tissue stress and trauma. The inhibitory actions of ADO are mediated by interactions with specific cell-surface G­ protein coupled receptors regulating membrane cation flux, polarization, and the release of ...
Elizabeth A. Kowaluk, Shripad S. Bhagwatt, Michael F. Jarvis   +2 more
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Dipyridamole affects myocardial adenosine kinase activity

Archives Internationales de Physiologie et de Biochimie, 1979
Adenosine kinase (EN 2.7.1.20) from rat and dog heart was purified until it was devoid of adenosine deaminase activity. A stimulation of adenosine kinase activity by dipyridamole was observed when the enzyme was assayed under optimal conditions. At low substrate concentrations adenosine kinase was inhibited by the drug.
J W, de Jong, E, Keijzer
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Adenosine kinase from Trypanosomacruzi

Biochemical and Biophysical Research Communications, 1982
Abstract Adenosine kinase was demonstrated in the soluble fraction of Trypanosoma cruzi . Magnesium is required for activity. ATP and GTP are efficient phosphate donors while p - nitrophenylphosphate is without activity. The pH optimum is high (8.0), it is heat labile and is stabile to freezing (−20° or −80°). It is substrate inhibited,
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Erythrocyte adenosine kinase activity in gout

Clinica Chimica Acta, 1976
Erythrocyte adenosine kinase (AK) (EC 2.7.1.20) and guanosine monophosphate (GMP) reductase (EC 1.6.6.8) were measured in healthy male controls and primary gout subjects. Adenosine kinase activity in 19 controls and 26 gouty subjects was 0.717 +/- 0.176 and 0.615 +/- 0.128 nmol/mg protein/h, respectively. The difference was statistically significant (p
T, Nishizawa, Y, Nishida, I, Akaoka
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Adenosine Metabolism, Adenosine Kinase, and Evolution

2012
The enzyme adenosine kinase (AdK, ADK, or AK) plays an important role in regulating the intracellular as well as extracellular concentrations of adenosine and hence its diverse physiological actions. In view of the enormous pharmacological potential of adenosine, there has been much interest in studying adenosine kinase over the past few decades.
Jaoek Park, Radhey S. Gupta
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Adenosine kinase inhibitors attenuate opiate withdrawal via adenosine receptor activation

European Journal of Pharmacology, 1998
Previous studies have demonstrated a role for adenosine in mediating opiate effects. This study examines the effects of indirect activation of adenosine receptors, via treatment with adenosine kinase inhibitors, on the expression of opiate withdrawal in mice.
G B, Kaplan, T S, Coyle
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Therapeutic potential of adenosine kinase inhibitors

Expert Opinion on Investigational Drugs, 2000
Adenosine kinase (AK; EC 2.7.1.20) is a key intracellular enzyme regulating intra and extracellular concentrations of adenosine (ADO), an endogenous modulator of intercellular signalling that reduces cell excitability during tissue stress and trauma. The inhibitory effects of ADO are mediated by interactions with specific cell-surface G-protein coupled
E A, Kowaluk, M F, Jarvis
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Hypoxia-Induced Inhibition of Adenosine Kinase Potentiates Cardiac Adenosine Release

Circulation Research, 1997
Abstract To elucidate the physiological role of the AMP-adenosine metabolic cycle and to investigate the relation between AMP and adenosine formation, the O 2 supply of isolated guinea pig hearts was varied (95% to 10% O 2 ).
U K, Decking, G, Schlieper, K, Kroll, J, Schrader   +3 more
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