Results 161 to 170 of about 225,984 (308)

Lysine acetyltransferase 2A-mediated succinylation of adenosine monophosphate-activated protein kinase suppresses gallstone formation by inhibiting inflammation and pyroptosis. [PDF]

World J Gastroenterol
Wang XX, Ma MZ, Zhu LC, Dai LF, Qin C, Shao S, Xu XW, Gao RX, Zhang ZH.   +8 more
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

MetaAMPK: Accurate Prediction of Adenosine Monophosphate-Activated Protein Kinase Activators Using a Meta-Learner Neural Network. [PDF]

ACS Omega
Intan AEK, Zetta DN, Jarukamjorn K, Srisongkram T.   +3 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Structural Heterogeneity of Proteoform-Ligand Complexes in Adenosine Monophosphate-Activated Protein Kinase Uncovered by Integrated Top-Down Mass Spectrometry. [PDF]

J Am Chem Soc
Chan HJ, Krichel B, Bandura LJ, Chapman EA, Rogers HT, Fischer MS, Roberts DS, Gao Z, Wang MD, Wu J, Uetrecht C, Jin S, Ge Y.   +12 more
europepmc   +1 more source

Downregulation of cyclic adenosine monophosphate levels in leukocytes of hibernating captive black bears is similar to reported cyclic adenosine monophosphate findings in major depressive disorder. [PDF]

Front Psychiatry, 2023
Tsiouris JA, Flory M.
europepmc   +1 more source

Determination and quantification of cyclic guanosine- and cyclic adenosine monophosphate (cGMP and cAMP) in human plasma and animal tissues by HILIC SPE in combination with LC-MS/MS [PDF]

, 2012
Lynen, Frederic, Sandra, Patrick, Van Damme, Thomas, Zhang, Yanhua   +3 more
core   +3 more sources

Activation of peripheral NOP receptors reduces periorbital mechanical allodynia evoked by CGRP in mice

British Journal of Pharmacology, EarlyView.
Background and Purpose Migraine is a neurovascular disorder largely mediated by calcitonin gene‐related peptide (CGRP). This study explores the role of the nociceptin/orphanin FQ (N/OFQ)–N/OFQ receptor (NOP) system in CGRP‐induced periorbital mechanical allodynia (PMA) in mice.
Chiara Sturaro, Pietro Pola, Michela Argentieri, Alessia Frezza, Matilde Marini, Francesco De Logu, Valentina Albanese, Marie Soukupova, Davide Malfacini, Nurulain T. Zaveri, Romina Nassini, Dane D. Jensen, Pierangelo Geppetti, Girolamo Calò, Chiara Ruzza   +14 more
wiley   +1 more source

TrkA of <i>Streptococcus mitis</i> CCUG31611 binds cyclic di-adenosine monophosphate and is required for growth in low potassium conditions. [PDF]

Microbiology (Reading)
Vevik K, Sribasgaran B, Cai K, Naemi AO, Pedersen Kaspersen H, Uhlig S, Økstad OA, Simm R.   +7 more
europepmc   +1 more source

Cyclic adenosine monophosphate-elevating agents inhibit amyloid-beta internalization and neurotoxicity: their action in Alzheimer's disease prevention. [PDF]

Neural Regen Res, 2023
Gopalakrishna R, Oh A, Bhat NR, Mack WJ.
europepmc   +1 more source