Results 71 to 80 of about 165,902 (383)
Ultraslow water-mediated transmembrane interactions regulate the activation of A$_{\text{2A}}$ adenosine receptor [PDF]
Biophys. J. (2016) vol. 111, 1180-1191, 2016 Water molecules inside G-protein coupled receptor have recently been spotlighted in a series of crystal structures. To decipher the dynamics and functional roles of internal waters in GPCR activity, we studied A$_{\text{2A}}$ adenosine receptor using $\mu$sec-molecular dynamics simulations.
arxiv +1 more source
Nucleotides: Structure and Properties [PDF]
, 2005 Nucleotides consist of a nitrogen-containing base, a five-carbon sugar, and one or more phosphate groups. Cells contain many types of nucleotides, which play a central role in a wide variety of cellular processes, including metabolic regulation and the ...
Bowater, RP
core +1 more source
Advanced Science, EarlyView.A single dual‐emission two‐photon fluorescent probe is designed for simultaneously tracking tyrosinase (TYR) and adenosine triphosphate (ATP). With the help of this probe, the intricate correlation and regulatory mechanism between TYR and ATP during oxidative stress is uncovered.
Hong Huang +12 more
wiley +1 more source
Uptake of adenosine 5'-monophosphate by Escherichia coli [PDF]
Journal of Bacteriology, 1975 Adenosine 5'-monophosphate is dephosphorylated before its uptake by cells of Escherichia coli. This is demonstrated by using a radioactive double-labeled culture, and with a 5'-nucleotidase-deficient, mutant strain. The adenosine formed is further phosphorolyzed to adenine as a prerequisite for its uptake and incorporation. The cellular localization of
E Yagil, I R Beacham
openaire +3 more sources
Effects of cyclic adenosine 3,5-monophosphate on photoreceptor disc shedding and retinomotor movement. Inhibition of rod shedding and stimulation of cone elongation. [PDF]
, 1982 As a test of the hypothesis that cyclic nucleotides play a role in the regulation of retinomotor movements and disc shedding in the photoreceptor-pigment epithelial complex, we have used an in vitro eyecup preparation that sustains both disc shedding and
Besharse, J, BURNSIDE, Beth, Dunis, D
core +1 more source
Advanced Science, EarlyView.The upregulation of FTO in autoimmune dry eye suppresses the recognition of pri‐miR‐31 by DGCR8, thereby inhibiting the maturation of miR‐31‐5p and reducing its inhibitory effect on the target gene P2RX7. The activation of P2RX7 subsequently triggers the p38 MAPK signaling pathway and increases the level of M1‐related genes, thus exacerbating the ...
Lu Zhao +10 more
wiley +1 more source
Structural Basis for the Catalytic Mechanism of ATP‐Dependent Diazotase CmaA6
Angewandte Chemie, EarlyView.Several diazotases have been reported in recent years, but the detailed catalytic mechanism is unclear. From X‐ray crystallography and Cryo‐EM analysis, we obtained the structure of a diazotase CmaA6, which synthesizes 3‐diazocoumaric acid. Kinetic analysis and computational analysis indicated that CmaA6 catalyzes diazotization via an unprecedented ...
Seiji Kawai +5 more
wiley +2 more sources
Broadband terahertz time-domain spectroscopy and fast FMCW imaging: principle and applications [PDF]
, 2020 We report a broadband terahertz time-domain spectroscopy (THz-TDS) which enables twenty vibrational modes of adenosine nucleoside to be resolved in a wide frequency range of 1-20 THz. The observed spectroscopic features of adenosine are in good agreement with the published spectra obtained using Fourier Transform Infrared Spectroscopy (FTIR) and Raman ...
arxiv +1 more source
Advanced Science, EarlyView.These findings reveal that silicon exerts strong protective effects in diabetic bone defect models by selectively promoting Drp1‐Mff activity. Silicon facilitates precise regulation of mitochondrial dynamics to enable functional mitochondrial transfer.
Yu‐Xuan Ma +12 more
wiley +1 more source
Food Science &Nutrition, Volume 11, Issue 1, Page 181-190, January 2023., 2023 Our project aims to reveal the cryoprotective effect of flammulina velutipes polysaccharide (FVP) on the quality characteristics in freeze‐thawed cultured large yellow croaker. The differences were compared with conventional commercial cryoprotectant in combination with muscle quality, body color, and flavor.
Yuzhuo Shi +5 more
wiley +1 more source