Results 261 to 270 of about 350,006 (309)

Cascade‐Targeted Nanoparticles for Enhanced Gemcitabine Delivery and Adenosine Metabolism Modulation to Overcome Treatment Resistance in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
The aberrant adenosine metabolism leads to chemoresistance and immunosuppressive microenvironment. A versatile albumin‐polyplexes conjugated nanoparticle B‐PDEA@CPA is prepare for the codelivery of gemcitabine and siCD39. The nanoparticle releases gemcitabine‐loaded albumin upon microenvironment to achieve promoted penetration and cellular uptake ...
Hongrui Fan   +10 more
wiley   +1 more source

Inactivation of adenosine receptor 2A suppresses endothelial-to-mesenchymal transition and inhibits subretinal fibrosis in mice. [PDF]

open access: yesSci Transl Med
Yang Q   +15 more
europepmc   +1 more source

Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine

open access: yesAdvanced Science, EarlyView.
Naturally derived biomembrane nanostructures by mimicking evolutionarily optimized biological architectures could effectively suppress tumor growth and have emerged as a compelling strategy in translational biomedicine. This review provides a systematic overview of rational design and underlying antitumor therapeutic mechanisms of mammalian cells ...
Xiaodan Wei   +10 more
wiley   +1 more source

Type 2 Diabetes‐Associated Phenylacetylglutamine Induces Deleterious Inflammation Cycle in Myeloid Cells through β2 Adrenergic Receptors and Impedes Wound Healing

open access: yesAdvanced Science, EarlyView.
The microbiota‐derived metabolite phenylacetylglutamine (PAGln) is elevated in type 2 diabetes and tightly associated with poor healing in both diabetic and non‐diabetic human patients. PAGln promotes mouse inflammation and impairs healing through a transmissible β2‐adrenergic receptor–mediated trained‐immunity loop.
Lu Huang   +12 more
wiley   +1 more source

Divergent Delivery and Expression Kinetics of Lipid and Polymeric Nanoparticles across mRNA Modalities

open access: yesAdvanced Science, EarlyView.
Self‐amplifying (saRNA), linear (linRNA), and circular (circRNA) mRNAs are compared under standardized conditions using lipid nanoparticles (LNPs) and pABOL polymer. saRNA achieved superior expression, while linRNA and circRNA performance varied based on untranslated region elements and delivery method.
Irafasha C. Casmil   +12 more
wiley   +1 more source

Dynamic eIF3‐S6 Phase Separation Switch Instructed by m6A Modification Drives the Molting of Locusts

open access: yesAdvanced Science, EarlyView.
This research reveals that reduced m6A modifications during insect molting trigger liquid–liquid phase separation (LLPS) of the m6A reader eIF3‐S6, which binds and stabilizes key molting mRNAs, including EcR and Cht10. Disrupting m6A or LLPS causes cuticle remodeling defects and molting failure, highlighting the synergistic control of gene expression ...
Zhihao Hu   +8 more
wiley   +1 more source

Macrophage Phenotype Detection Methodology on Textured Surfaces via Nuclear Morphology Using Machine Learning

open access: yesAdvanced Intelligent Discovery, EarlyView.
A novel machine learning approach classifies macrophage phenotypes with up to 98% accuracy using only nuclear morphology from DAPI‐stained images. Bypassing traditional surface markers, the method proves robust even on complex textured biomaterial surfaces. It offers a simpler, faster alternative for studying macrophage behavior in various experimental
Oleh Mezhenskyi   +5 more
wiley   +1 more source

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